Fasting plasma magnesium concentrations and glucose disposal in diabetes.

Yajnik, C.S.; Smith, Robin; Hockaday, T. D. R.; Ward, N. I.

doi:10.1136/bmj.288.6423.1032

Cited by 114 publications

(74 citation statements)

References 14 publications

(6 reference statements)

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“…19 Serum levels of magnesium have been found by several investigators to correlate inversely with fasting blood glucose concentration, post prandial blood glucose and the percentage of HbA1C. 8,20,[22][23][24][25] The present study also revealed that patients with low serum magnesium levels had poor glycemic control. There was statistically significant association between low serum magnesium levels and higher FBS, PPBS and HbA1C%.…”

Section: Discussionsupporting

confidence: 55%

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

et al. 2017

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INTRODUCTIONThe term diabetes mellitus (DM, derived from Greek words meaning -Siphon and sweet) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia which results from reduced insulin secretion and/or action, decreased glucose utilization, and increased glucose production. Incidence of diabetes is increasing worldwide due to population ageing and growth, obesity, unhealthy diets and sedentary life style. Microvascular and macrovascular complications of diabetes increase as a function of the duration of hyperglycemia. So, a reduction of chronic hyperglycemia prevents or delays these complications. 1Magnesium is an essential element and has a fundamental role in carbohydrate metabolism in general and in the insulin action in particular. Magnesium is a cofactor in ABSTRACT Background: Hypomagnesemia has been proposed as a novel factor implicated in the pathogenesis of poor glycemic control and diabetic complications. Aim of the present study is to study serum magnesium level in patients with type 2 DM and to find the correlation between serum magnesium levels, HbA1c and diabetic complications. Methods: 100 patients with Type 2 DM (50 males and 50 females) who were diagnosed on the basis of ADA criteria or taking treatment for Diabetes were included in the study. All patients underwent tests for serum magnesium level, fasting blood sugar, postprandial blood sugar, HbA1c and also target organ evaluation for Diabetes. A detailed history and examination was also done. Results: There was significant difference in the prevalence of hypomagnesemia (34% versus 6%) and serum magnesium levels (1.59±0.187 versus 1.78±0.126, p <0.0001) between diabetics and control group. FBS (172.17±30.55 versus 137.06±37.76, p<0.0001), PPBS (243±61.21 versus 195.84±59.1, p = 0.0003) and HbA1C (8.42±1.292 versus 7.04±0.956, p<0.0001) were significantly higher in hypomagnesemic diabetics as compared to normomagnesemic diabetics. Significant proportion of hypomagnesemic diabetics were suffering from retinopathy as compared to normomagnesemic diabetics (47.06% versus 19.70%, p = 0.0042). Diabetic nephropathy, neuropathy, hypertension and IHD were also higher in hypomagnesemic diabetics as compared to normomagnesemic diabetics, but insignificant. Conclusions: Prevalence of hypomagnesemia in Type 2 diabetics was 34%. Diabetics with hypomagnesemia had poor glycemic control. Hypomagnesemia was significantly associated with diabetic retinopathy.

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Section: Discussionsupporting

confidence: 55%

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

et al. 2017

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“…In effect, hypermagnesemia inhibits insulin secretion (Zofkova et al, 1988), while it enhances insulin sensitivity through increase in binding affinity of insulin to its receptors (Yajnlk et al, 1984;Paolisso et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Effect of magnesium supplementation on plasma glucose in patients with diabetes mellitus

Meludu¹,

Adeniyi²

2010

African Journal of Biomedical Research

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“…A complex interplay exists between magnesium and glucose metabolisms. It plays an important role in the activities of various enzymes which are involved in glucose oxidation, and it may play a role in the release of insulin [17][18][19]. It is mainly intracellular and its uptake is stimulated by insulin [19,20].…”

Section: Discussionmentioning

confidence: 99%

Trace Elements in Diabetes Mellitus

Praveeena¹,

Pasula²,

K³

2013

JCDR

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Introduction: Diabetes Mellitus is the commonest major metabolic disease and most prevalent diseases worldwide. Its related morbidity is due to its micro and macro angiopathic complications. Aim:The aim of this study was to measure and compare the serum levels of zinc and magnesium in normal individuals and in diabetic patients.Method: Analysis of minerals was done in plasma by using a Varian Spectra AA 220 model atomic absorption spectrophotometer. Result:Our observations showed a definite lowering of serum magnesium (p<0.001) and serum zinc levels (p<0.001) were significant in diabetic group. Conclusion:The cause of diabetic hypomagnesaemia is multifactorial. An altered metabolism, a poor glycaemic control and osmotic diuresis may be contributory factors. Decreased serum zinc levels in diabetes may be caused by an increase in urinary loss. These decreased levels of trace elements cause disturbances in glucose transport across cell membrane lead to insufficient formation and secretion of insulin by pancreas which compromise in the antioxidant defense mechanisms.

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Fasting plasma magnesium concentrations and glucose disposal in diabetes.

Cited by 114 publications

References 14 publications

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

Effect of magnesium supplementation on plasma glucose in patients with diabetes mellitus

Trace Elements in Diabetes Mellitus

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