Fasting plasma glucose, oral glucose tolerance test, and the risk of first-time venous thromboembolism. A report from the VEINS cohort study.

Johansson, Magdalena; Lind, Marcus; Jansson, Jan‐Håkan; Fhärm, Eva; Johansson, Lars

doi:10.1016/j.thromres.2018.03.015

Cited by 17 publications

(17 citation statements)

References 22 publications

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“…The VIP health examinations and the VEINS study have been described in detail in previous publications. 23,24 Participants in the VIP health examinations from 1985 onwards were included in this study and followed as a cohort until experiencing a first-time VTE event, emigration, death or end of follow-up on 5 September 2014. The VEINS cohort included 108,025 individuals.…”

Section: Methodsmentioning

confidence: 99%

“…The identification and validation of VTE events have been previously described. 24 All VTE events experienced by VIP participants from the VIP health examination date to 5 September 2014, were identified by diagnosis registry search for International Classification of Diseases (ICD) diagnostic codes for potential VTE events. A search for a sub-set of the ICD codes was made in the Cause of Death Register.…”

Section: Identification and Validation Of Vte Eventsmentioning

confidence: 99%

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Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women

Johansson

Wennberg

et al. 2019

Thromb Haemost

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Background The relationship between alcohol intake and risk of venous thromboembolism (VTE) is unclear. Men and women differ in their drinking habits, which may affect a possible association. Objective This article investigates the association between alcohol consumption, alcohol dependence and VTE in the total population as well as in men and women separately. Methods We performed a prospective, population-based cohort study in northern Sweden. Study participants were 108,025 (51% women) persons aged 30 to 60 years who underwent a health examination between 1985 and 2014. We assessed alcohol consumption and defined alcohol dependence using a questionnaire. The outcome was a validated first-time VTE. Results The mean follow-up time was 13.9 years, and 2,054 participants had a first-time VTE. The mean alcohol consumption was 3.5 standard drinks weekly in men and 1.5 in women. Alcohol dependence was found in 10% of men and 3% of women. There was an association between alcohol consumption (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.00–1.03 per standard drink weekly) as well as alcohol dependence (HR, 1.27; 95% CI, 1.06–1.52) and VTE after adjustments. In men, the risk of VTE increased over quartiles of weekly alcohol consumption (p for trend 0.02), with a HR of 1.22 (95% CI, 1.01–1.47) for the highest quartile. Alcohol dependence was associated with VTE in men (HR, 1.30; 95% CI, 1.07–1.59). In women, there were no significant associations. Conclusion High alcohol consumption and alcohol dependence were associated with increased risk of first-time VTE in men, but not in women.

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Section: Methodsmentioning

confidence: 99%

Section: Identification and Validation Of Vte Eventsmentioning

confidence: 99%

Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women

Johansson

Wennberg

et al. 2019

Thromb Haemost

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“…The Västerbotten Intervention Programme (VIP) health examinations and the Venous thromboEmbolism In Northern Sweden (VEINS) study have been described in detail in previous publications, 32,33 and are summarized below.…”

Section: Methodsmentioning

confidence: 99%

“…The identification and validation of VTE events were described previously. 33 All VTE events experienced by VIP participants from the VIP health examination date to 5 September 2014 were identified by a diagnosis registry search for International Classification of Diseases (ICD) diagnostic codes for potential VTE events. The Cause of Death Register was searched for a subset of the ICD codes.…”

Section: Methodsmentioning

confidence: 99%

Physical activity and risk of first-time venous thromboembolism

Johansson

Wennberg

et al. 2019

Eur J Prev Cardiolog

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“…The Venous Thromboembolism in Northern Sweden (VEINS) study is a prospective study on the risk markers for VTE. 8 , 9 The cohort comprises 108,413 participants, aged 30–60 years, who were invited to undergo a health examination between January 1, 1985, and September 5, 2014 as part of a large health screening program. The participation rate has been reported to be 65%.…”

Section: Methodsmentioning

confidence: 99%

Positive predictive value and misclassification of diagnosis of pulmonary embolism and deep vein thrombosis in Swedish patient registries

Öhman¹,

Johansson²,

Jansson³

et al. 2018

CLEP

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PurposeTo validate diagnoses of pulmonary embolism (PE) and deep vein thrombosis (DVT) in administrative registries. We also estimated the frequency of misclassified PE and DVT events.Patients and methodsA registry search for ICD codes representing PE and DVT was performed between 1985 and 2014 in a large population-based cohort in northern Sweden. An additional search using an extended set of ICD codes was performed to identify misclassified events. Diagnoses were validated manually by reviewing medical records and radiology reports.ResultsSearching ICD codes in the National Patient Registry and Cause of Death Registry identified 2,450 participants with a first-time diagnosis of PE or DVT. The positive predictive value (PPV) for a diagnosis of PE or DVT was 80.7% and 59.2%, respectively. For the period of 2009 to 2014, the PPV was higher for PE (85.8%) but lower for DVT (54.1%). Misclassification occurred in 16.4% of DVT events and 1.1% of PE events.ConclusionRegistry-based data on PE, especially in recent years, are of acceptable quality and can be considered for use in registry-based studies. For DVT, we found that data were of low quality in regards to both PPV and misclassification and should not be used without validation.

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Fasting plasma glucose, oral glucose tolerance test, and the risk of first-time venous thromboembolism. A report from the VEINS cohort study.

Cited by 17 publications

References 22 publications

Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women

Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women

Physical activity and risk of first-time venous thromboembolism

Positive predictive value and misclassification of diagnosis of pulmonary embolism and deep vein thrombosis in Swedish patient registries

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