Fasting Plasma Glucose in the Screening for Type 2 Diabetes in Morbidly Obese Subjects

Hofsø, Dag; Jenssen, Trond; Hager, Helle Borgstrøm; Røislien, Jo; Hjelmesæth, Jøran

doi:10.1007/s11695-009-0022-5

Cited by 40 publications

(26 citation statements)

References 34 publications

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“…In our study, we excluded patients only using insulin because most of these patients will have type 1 DM. Thus, the real prevalence for T2DM in our study population may be slightly higher than 19.1% and comparable with the prevalence of known diabetes (23%) in morbidly obese patients reported by Hofsø et al 8 ported a decrease in the use of oral antidiabetics from 16.3% to 4.0% on average 3 years after bariatric surgery. However, as several types of gastric bypass surgery were used in more than 85% of the patients included in their study, their results should not be compared with results from our study population in which gastric banding was more common.…”

Section: Discussionsupporting

confidence: 89%

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Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery

et al. 2015

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Population-based data show that bariatric surgery strongly increases the chance for remission of T2DM. Gastric bypass and sleeve gastrectomy have a greater effect than gastric banding. Although the risks and possible adverse effects of surgery should be weighed against its benefits, bariatric surgery and, in particular, gastric bypass or sleeve gastrectomy may be considered as new treatment options for T2DM.

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Section: Discussionsupporting

confidence: 89%

“…[5][6][7] As much as 23% of patients with morbid obesity have had type 2 DM (T2DM). 8 Bariatric surgery effectively prevents and treats T2DM. 4 Surgical treatment for obese patients may be considered an additional treatment option for the management of T2DM.…”

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confidence: 99%

Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery

et al. 2015

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“…This fully agrees with the well-recognized incidence and prevalence of T2D among severe obese subjects (29). It is possible that common underlying mechanisms leading to T2D are overrepresented in these subjects, and miRNA may constitute one of them.…”

Section: Increased Circulating Mirnas In T2dsupporting

confidence: 90%

Profiling of Circulating MicroRNAs Reveals Common MicroRNAs Linked to Type 2 Diabetes That Change With Insulin Sensitization

et al. 2014

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OBJECTIVEThis study sought to identify the profile of circulating microRNAs (miRNAs) in type 2 diabetes (T2D) and its response to changes in insulin sensitivity. RESEARCH DESIGN AND METHODSThe circulating miRNA profile was assessed in a pilot study of 12 men: 6 with normal glucose tolerance (NGT) and 6 T2D patients. The association of 10 circulating miRNAs with T2D was cross-sectionally validated in an extended sample of 45 NGT vs. 48 T2D subjects (65 nonobese and 28 obese men) and longitudinally in 35 T2D patients who were recruited in a randomized, double-blinded, and placebo-controlled 3-month trial of metformin treatment. Circulating miRNAs were also measured in seven healthy volunteers before and after a 6-h hyperinsulinemiceuglycemic clamp and insulin plus intralipid/heparin infusion. RESULTSCross-sectional studies disclosed a marked increase of miR-140-5p, miR-142-3p, and miR-222 and decreased miR- 423-5p, miR-125b, miR-192, miR-195, miR-130b, miR-532-5p, and miR-126 in T2D patients. Multiple linear regression analyses revealed that miR-140-5p and miR-423-5p contributed independently to explain 49.5% (P < 0.0001) of fasting glucose variance after controlling for confounders. A discriminant function of four miRNAs (miR-140-5p, miR-423-5p, miR-195, and miR-126) was specific for T2D with an accuracy of 89.2% (P < 0.0001). Metformin (but not placebo) led to significant changes in circulating miR-192 (49.5%; P = 0.022), miR-140-5p (215.8%; P = 0.004), and miR-222 (247.2%; P = 0.03), in parallel to decreased fasting glucose and HbA 1c . Furthermore, while insulin infusion during clamp decreased miR-222 (262%; P = 0.002), the intralipid/heparin mixture increased circulating miR-222 (163%; P = 0.015) and miR-140-5p (67.5%; P = 0.05). CONCLUSIONSThis study depicts the close association between variations in circulating miRNAs and T2D and their potential relevance in insulin sensitivity.

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“…In addition, other factors, including inheritance, ethnicity and age, are all associated with the incidence of T2D (4). A previous study identified that the metabolism of glucose and fatty acids by skeletal muscle is impaired in T2D (5). Reduced glucose transport and phosphorylation, as well as reduced rates of glycogen synthesis are common manifestations of insulin-resistant glucose metabolism (6).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes

Liu

Sun

Wang

et al. 2012

Molecular Medicine Reports

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Abstract. The present study aimed to examine the changes in DNA methylation of gene promoters associated with type 2 diabetes (T2D). The DNA methylation profile dataset GSE38291 was downloaded from the Gene Expression Omnibus database. A paired t-test was used to analyze differences in the DNA methylation of gene promoters between T2D and normal muscle samples. Gene Ontology (GO) enrichment analysis was performed using online tool, The Database for Annotation, Visualization and Integrated Discovery. Whole-Genome rVISTA was used to analyze the enriched transcription factor (TF) binding sites upstream of the transcription start site in the differentially methylated genes. A total of 38 genes, including Sirtuin 1, N-acetyltransferase 6, phospholipase A2 group XIIB and nuclear factor of activated T cells calcineurin-dependent 1, were identified to be differentially methylated between these two groups. One GO term, DNA geometric change (GO:0032392), was significantly enriched (P<0.05) by the hyper-methylated genes. In addition, the binding sites of one gene, zinc finger E-box binding homeobox 1, and three TFs, methyl CpG binding protein 2, TFEB and TFAP4, were significantly enriched in the hyper-and hypo-methylated genes, respectively. The resulting T2D-associated genes and potential TFs provided a novel insight into the molecular mechanisms underlying the pathology of T2D. These genes may become promising target genes for the development of treatments for T2D.

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Fasting Plasma Glucose in the Screening for Type 2 Diabetes in Morbidly Obese Subjects

Abstract: Fasting glucose identified four out of five morbidly obese subjects with unknown diabetes. A supplemental OGTT in selected persons identified the majority of the remaining diabetic cases.

Cited by 40 publications

References 34 publications

Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery

Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery

Profiling of Circulating MicroRNAs Reveals Common MicroRNAs Linked to Type 2 Diabetes That Change With Insulin Sensitization

Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes

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