Fasting plasma glucose and lipid profiles of diabetic patients improve with aerobic exercise training

Asuako, Benjamin; Moses, Monday Omoniyi; Eghan, Benjamin; Sarpong, Peter Akwasi

doi:10.4314/gmj.v51i3.5

Cited by 10 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A third study investigated the effects of aerobic exercise training and was able to decrease fasting plasma glucose. 28 Two other exercise interventions failed to reduce HbA1c by incremental exercises compared with relaxation Van Rooijen 2004 or higher intensity of exercises (Yan 2014) (figure 4). Results were not pooled due to considerable heterogeneity with different directions of treatment effects.…”

Section: Strategies To Enhance Physical Activitymentioning

confidence: 99%

Randomised controlled trials on prevention, diagnosis and treatment of diabetes in African countries: a systematic review

et al. 2022

View full text Add to dashboard Cite

ObjectivesThe epidemiological transition from infectious to chronic diseases leads to novel challenges in African health systems. The prevalence of diabetes mellitus (DM) is increasing dramatically. Undiagnosed and undertreated DM leads to numerous complications including end-organ damage and death. Our objectives were to collect the best locally generated evidence on DM interventions, identify knowledge gaps and determine underexplored research areas.DesignA systematic review and meta-analysis of randomised controlled trials.Participants and settingAfrican patients in primary, secondary and tertiary prevention, diagnosis and treatment DM type 1 (DM1), type 2 (DM2) and gestational DM (GDM).OutcomeAll-cause mortality, glycaemic control, complications, quality of life, hospital admission, treatment adherence and costs.Data sourcesArticles published in MEDLINE Ovid, CENTRAL, CINAHL, African Journals Online and African Index Medicus and the International Clinical Trials Registry Platform in English language without time restrictions. The systematic search was last updated in October 2020.ResultsOut of 3736 identified publications, we included 60 eligible studies conducted in 15 countries, 75% were conducted in urban healthcare settings, including 10 112 participants. We included 8 studies on DM1, 6 on GDM, 2 on pre-DM, 37 on mainly DM2 including 7 on DM-related complications. The design of the studied intervention was heterogeneous with a focus on educational strategies. The other studies investigated the efficacy of nutritional strategies including food supplementations, pharmacological strategies and strategies to enhance physical activity. Seven studies included interventions on DM-related complications.ConclusionsResearch activities increased in recent years, but available evidence is still not representative for all African countries. There is a big lack of evidence in primary healthcare and rural settings, implementation research, pharmacological interventions, especially in poorer countries. Nevertheless, the identified studies offer a variety of effective interventions that can inform medical care and future research.PROSPERO registration numberCRD42019122785.

show abstract

Section: Strategies To Enhance Physical Activitymentioning

confidence: 99%

Randomised controlled trials on prevention, diagnosis and treatment of diabetes in African countries: a systematic review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Existing studies have shown that aerobic exercises such as walking and running can significantly benefit the health and physical conditions of diabetic patients [22]. Aerobic exercise helps improve a patient's body weight, body mass index, and fasting plasma glucose levels [23]. In addition, aerobic exercise can also alleviate vascular endotheliumdependent dysfunction in pre-diabetic individuals [24].…”

Section: Introductionmentioning

confidence: 99%

Pressure-Reducing Design of 3D-Printed Diabetic Shoe Midsole Utilizing Auxetic Lattice Structure

Zhang,

Lu,

Lin

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

With the global rise in the prevalence of diabetes, diabetic patients need innovative footwear designs to reduce the risk of foot ulcers. This study examined the mechanical properties of diabetic shoe midsoles featuring auxetic lattice structures. Through the construction of finite element models and simulation, this research compared the biomechanical parameter differences in the plantar regions of the metatarsal head, midfoot, and hindfoot when wearing two types of auxetic midsoles with internal angles of 60° and 75° and a non-auxetic midsole with an internal angle of 90° under both walking and running conditions. Compared to the non-auxetic midsole, the auxetic midsoles significantly reduced the peak plantar pressure and optimized the pressure distribution across various plantar regions. Notably, the auxetic 60° midsole reduced the peak plantar pressure by 19.68–55.25% and 16.19–54.39% compared to the non-auxetic 90° midsole during walking and running, respectively. This study also verified that the auxetic midsoles exhibited greater adaptability and compliance to the plantar foot shape, contributing to reductions in plantar pressure in comparisons of deformation values and plantar contact areas across the different midsoles. Auxetic midsoles manufactured using 3D printing technology have significant potential to prevent diabetic foot ulcers and maintain human foot health. This research integrates insights and techniques from materials science and ergonomics, offering a new direction for footwear design.

show abstract

“…Regular aerobic exercise is widely recognised as a nonpharmacological approach to either reduce or prevent CVD morbidity and mortality. In animal models, aerobic exercise decreases blood TAG, increases HDL cholesterol (Mann et al, 2014), lowers blood pressure (Pedrinolla et al, 2018), improves glucose metabolism and insulin sensitivity (Asuako et al, 2017), reduces body weight and inflammation (Szostak & Laurant, 2011), and improves endothelial function and the bioavailability of nitric oxide (NO) (Medeiros et al, 2016;Olver et al, 2017). Finally, it modulates the expression of proteins and the micro-RNAs (miRs) that are enrolled in cell proliferation, protein synthesis, angiogenesis and anti-apoptotic events (Medeiros et al, 2016;Neves et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms underlying fructose‐induced cardiovascular disease: exercise, metabolic pathways and microRNAs

Kindlovits

Bertoldi

Rocha

et al. 2021

Experimental Physiology

View full text Add to dashboard Cite

During the onset of cardiovascular disease (CVD), disturbances in myocardial vascularization, cell proliferation and protein expression are observed. Aerobic training prevents CVD, but the underlying mechanisms behind left ventricle (LV) hypertrophy are not fully elucidated. The aim of this study was to investigate the mechanisms by which aerobic training protects the heart from LV hypertrophy during the onset of fructose-induced cardiometabolic disease. Male Wistar rats were allocated to four groups (n = 8/group): control sedentary (C), control training (CT), fructose sedentary (F) and fructose training (FT). The C and CT groups received drinking water, and the F and FT groups received D-fructose (10% in water). After 2 weeks, the CT and FT rats were assigned to a treadmill training protocol at moderate intensity for 8 weeks (60 min/day, 4 days/week). After 10 weeks, LV morphological remodelling, cardiomyocyte apoptosis, microRNAs and the insulin signalling pathway were investigated. The F group had systemic cardiometabolic alterations, which were normalised by aerobic training. The LV weight increased in the FT group, myocardium vascularisation decreased in the F group, and the cardiomyocyte area increased in the CT, F and FT groups. Regarding protein expression, total insulin receptor β-subunit (IRβ) decreased in the F group; phospho (p)-IRβ and phosphoinositide 3-kinase (PI3K) increased in the FT group; total-AKT and p-AKT increased in all of the groups; p-p70S6 kinase (p70S6K) protein was higher in the CT group; and p-extracellular signal-regulated kinase (ERK) increased in the CT and FT groups. MiR-126, miR-195 and cardiomyocyte apoptosis did not differ among the groups. Aerobic training activates p-p70S6K and p-ERK, and during the onset of a CVD, it can activate the IRβ-PI3K-AKT pathway.

show abstract

Fasting plasma glucose and lipid profiles of diabetic patients improve with aerobic exercise training

Cited by 10 publications

References 40 publications

Randomised controlled trials on prevention, diagnosis and treatment of diabetes in African countries: a systematic review

Randomised controlled trials on prevention, diagnosis and treatment of diabetes in African countries: a systematic review

Pressure-Reducing Design of 3D-Printed Diabetic Shoe Midsole Utilizing Auxetic Lattice Structure

Molecular mechanisms underlying fructose‐induced cardiovascular disease: exercise, metabolic pathways and microRNAs

Contact Info

Product

Resources

About