Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study

Zhang, Lizhen; Wang, Zhongge; Chen, Ruirui; Cheng, Zhiyuan; Yang, Jun; Li, Jing; Li, Siyu; Chen, Yarong; Xu, Lulu; Hu, Yujia; Bai, Yana

doi:10.1016/j.canep.2023.102362

Cited by 2 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the participants fasted overnight, samples for biochemical and biological tests were collected the morning after. The height and weight were measured by SK-X80/TCS-160D-W/H computer body scale produced by Shenzhen Shuangjia Electronics Co., Ltd (Zhang et al, 2023). The 7600-020 automatic biochemical analyzer produced by Hitachi was used to detect fasting plasma glucose (FPG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and other biochemical indicators.…”

Section: Data Collectionmentioning

confidence: 99%

Association between metabolic syndrome and the risk of colorectal cancer: a prospective study in China

Wang,

Chen,

Zhang

et al. 2023

European Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

Objective To evaluate the correlation between metabolic syndrome (MetS) and its components on the incidence of colorectal cancer (CRC) based on data from Jinchang Cohort. Methods This is a large prospective cohort study. Between 2011 and 2020, a total of 43 516 individuals from Jinchang Cohort were included for this study. Hazard ratios (HRs) with 95% confidence intervals (CIs) for CRC according to MetS were calculated with the Cox proportional hazard models. The restricted cubic spine models with four knots were conducted to fit the dose-response relationships. Results MetS was associated with increased risk of CRC (n = 141; HR: 1.64, 95% CI: 1.15–2.33) after adjusting for confounding factors (age, sex, education level, family history of CRC, smoking index and alcohol index). Participants with hyperglycemia had a significantly higher risk of developing incident CRC (HR: 1.70; 95% CI: 1.19–2.43). The positive association between MetS and CRC was observed in males (HR: 1.76; 95% CI: 1.17–2.63), but not in females (HR: 1.24; 95% CI: 0.59–2.64). Furthermore, linear dose-response relationship was found between fasting plasma glucose (FPG) and CRC risk in males (P overall < 0.05, P non-linear = 0.35). When stratified by smoke and drink, MetS was found to increase the incidence of CRC only in the smoke (HR: 2.07, 95% CI: 1.35–3.18) and drink (HR: 2.93, 95% CI: 1.51–5.69) groups. Conclusion MetS was associated with a higher risk of CRC incidence. Hyperglycemia lended strong support to the role of MetS in new-onset CRC, especially in males. Other components of MetS were not found to be associated with increased risk of CRC.

show abstract

Section: Data Collectionmentioning

confidence: 99%