Fasting and Postprandial Myoelectric Spiking Activity in the Human' Sigmoid Colon

Schang, J. C.; Devroede, Ghislain

doi:10.1016/s0016-5085(83)80070-5

Cited by 68 publications

(21 citation statements)

References 23 publications

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“…Bueno et al found a prominent presence of cyclic electrical activity between 10 and 12 cpm . Couturier et al found the most prominent frequency between 8.4 and 10.6 cpm, similar to Schang and Devroede, their average was 10 cpm . Consistently, in vitro studies of the human colon circular muscle showed prominently a slow wave activity in a similar frequency range .…”

Section: Discussionmentioning

confidence: 59%

The cyclic motor patterns in the human colon

Pervez

Ratcliffe

Parsons

et al. 2020

Neurogastroenterology Motil

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are co-senior authors.Abbreviations: CMP, Cyclic motor pattern; HAPW, High-amplitude propagating pressure wave; SPW, Simultaneous pressure wave. AbstractBackground: High-resolution colonic manometry gives an unprecedented window into motor patterns of the human colon. Our objective was to characterize motor activities throughout the entire colon that possessed persistent rhythmicity and spanning at least 5 cm.Methods: High-resolution colonic manometry using an 84-channel water-perfused catheter was performed in 19 healthy volunteers. Rhythmic activity was assessed during baseline, proximal balloon distention, meal, and bisacodyl administration.Key Results: Throughout the entire colon, a cyclic motor pattern occurred either in isolation or following a high-amplitude propagating pressure wave (HAPW), consisting of clusters of pressure waves at a frequency centered on 11-13 cycles/min, unrelated to breathing. The cluster duration was 1-6 minutes; the pressure waves traveled for 8-27 cm, lasting 5-8 seconds. The clusters itself could be rhythmic at 0.5-2 cpm.The propagation direction of the individual pressure waves was mixed with >50% occurring simultaneous. This high-frequency cyclic motor pattern co-existed with the well-known low-frequency cyclic motor pattern centered on 3-4 cpm. In the rectum, the low-frequency cyclic motor pattern dominated, propagating predominantly in retrograde direction. Proximal balloon distention, a meal and bisacodyl administration induced HAPWs followed by cyclic motor patterns. Conclusions and Inferences:Within cyclic motor patterns, retrograde propagating, low-frequency pressure waves dominate in the rectum, likely keeping the rectum empty; and mixed propagation, high-frequency pressure waves dominate in the colon, likely promoting absorption and storage, hence contributing to continence.Propagation and frequency characteristics are likely determined by network properties of the interstitial cells of Cajal. K E Y W O R D S colonic motility, cyclic motor pattern, high-resolution colonic manometry, interstitial cells of Cajal, rectal pressure waves S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section.

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Section: Discussionmentioning

confidence: 59%

The cyclic motor patterns in the human colon

Pervez

Ratcliffe

Parsons

et al. 2020

Neurogastroenterology Motil

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“…Electric activity has been recorded from the gut in the form of slow waves or pacesetter potentials (PPs) in normal subjects and patients with various pathologies of the bowel (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The PPs in normal ___________________________________________ Received 05/21/96; Accepted 06/12/96 1 To whom correspondence should be addressed, at 2 Talaat Harb Street, Cairo, Egypt.…”

Section: Introductionmentioning

confidence: 99%

“…The PPs in normal ___________________________________________ Received 05/21/96; Accepted 06/12/96 1 To whom correspondence should be addressed, at 2 Talaat Harb Street, Cairo, Egypt. Tel/Fax #: +20-2-349 8851 subjects were regular and consistent when repeated in the same individual (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). They were followed randomly by spikes of action potentials (APs) which were inconsistent and which were associated with elevation of rectal pressure (10,11).Various pathologies of the bowel have been associated with electrorectographic irregularities (12,13).…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous electrosigmoidography Study of the myoelectric activity of sigmoid colon by surface electrodes

Shafik

1996

Front Biosci

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The purpose of this study was to determine the feasibilty of performing transcutaneous electrosigmoidography (TC-ESG). The study involved 19 healthy volunteers (11 men, 8 women; mean age 38.2 +/- 14.8 years). To validate the results of TC-ESG, the latter was performed simultaneously with intra-sigmoid ESG. TC-ESG was done also in five patients who underwent sigmoidectomy. The optimal position of the electrodes was determined after several trials. Two electrodes (Beckman) were applied, each 2-3 cm away from the middle of a line drawn from the umbilicus to the symphysis pubis. A third electrode was placed just above the symphysis pubis. A reference electrode was applied to one of the lower limbs. For intra-sigmoid IS-ESG, two silver-silver chloride electrodes were introduced from the anal orifice into the sigmoid colon and were attached to the mucosa by suction. Pacesetter potentials (PPs) were recorded as regular negative deflections. They had constant amplitude, frequency and velocity when recordings were obtained in the same subject. The PPs registered transcutaneously had the same amplitude, frequency and velocity as those recorded intrasigmoidally. Action potentials could be registered only intrasigmoidally and not transcutaneously. No electric waves could be recorded by TC-ESG in 5 patients who had undergone sigmoidectomy. In conclusion, TC-ESG is a simple, non-invasive and non-radiologic technique that can substitute intra-sigmoid ESG and potentially can be used in the diagnosis of various pathologic conditions of sigmoid colon.

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“…[8][9][10] Previous studies have shown that the colon normally exhibits electric activity in the form of slow waves, or pacesetter potentials (PPs), and fast activity spikes, or action potentials (APs). [11][12][13][14][15][16][17][18] Action potentials occur randomly and follow, or are superimposed on, the PPs, and they are coupled with elevated colonic pressure. The electric waves are transmitted through smooth muscles of the gut and are partially controlled by intrinsic and extrinsic colonic innervation.…”

Section: Discussionmentioning

confidence: 99%

Colonic Pacing

Shafik

Shafik²,

El-Sibai³

et al. 2004

Arch Surg

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The treatment of constipation caused by total colonic inertia is problematic and its results are unsatisfactory. We speculated that colonic pacing would initiate electric activity in the inertial colon and effect rectal evacuation. Methods: Nine patients with constipation due to total colonic inertia (age range, 39-52 years; 7 women, 2 men) were enrolled in the study. One pacing electrode was applied to each of the 4 potential colonic pacemaker sites, and 2 to 3 temporary recording electrodes were applied distally. A stimulator was embedded subcutaneously in the inguinal area. Home pacing was practiced after patients were trained; the recording electrodes were removed before home pacing was started. Results: Colonic pacing evoked electric waves, which

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Fasting and Postprandial Myoelectric Spiking Activity in the Human' Sigmoid Colon

Cited by 68 publications

References 23 publications

The cyclic motor patterns in the human colon

The cyclic motor patterns in the human colon

Transcutaneous electrosigmoidography Study of the myoelectric activity of sigmoid colon by surface electrodes

Colonic Pacing

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