Faster wound healing with topical negative pressure therapy in difficult to heal wounds

Laat, Erik de

doi:10.1186/isrctn36051617

Cited by 32 publications

(9 citation statements)

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“…II). [24][25][26][27][28][29] Quality assessment of the included studies. Since all the included studies are RCTs the quality assessment was based on the risk of bias.…”

Section: Resultsmentioning

confidence: 99%

“…Only two trials evaluated ulcer healing: Ashby 25 and de Laat. 26 In the first study only one pressure ulcer (16.6%) which underwent NPWT (79 days) healed; in the other study the authors performed a subgroup analysis of patients with pressure ulcers, but they did not describe the results and reported only the conclusion ("statistically significantly faster wound healing in the topical negative pressure group") 20 (Tab. IV).…”

Section: Resultsmentioning

confidence: 99%

“…Ashby showed that only one pressure ulcer (17%) healed in NPWT group, 25 whereas de Laat reported only a "statistically significantly faster wound healing". 26 Different results were found in the trials that described the reduction in ulcer volume with different type of measure -length and width of ulcer, mean (SD) time to reach 50% of the initial volume, mean percent reduction in ulcer volume). In this outcome the results are different: Dwivedi reported statistically significant better results in patients underwent NPWT.…”

Section: Discussionmentioning

confidence: 97%

“…32 In this systematic review, six randomized controlled trials were included. [24][25][26][27][28][29] In the two groups the characteristics of patients were similar, but the high heterogeneity regarding interventions, comparisons and outcomes rendered the data not suitable to perform meta-analysis. All trials have agreed that the pressure ulcers healed better in patients underwent NPWT, but the data reported are very poor.…”

Section: Discussionmentioning

confidence: 99%

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Negative pressure wound therapy versus healing by secondary intention in pressure ulcers

Cirocchi¹,

G²,

Mutafchiyski³

et al. 2017

NPWTJ

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REVIEWAbstract-: Pressure ulcers are a highly prevalent source of morbidity with an equally high incidence of up to 38.0% amongst different categories of healthcare institutions. Therefore, the management and therapeutic approach toward these often hospital-or facility-acquired problems remain critical aspects of long-term care. Negative pressure wound therapy (NPWT) has proven effective in addressing the barriers to pressure ulcer healing including increasing blood flow to previously ischemic wound areas by generating subatmospheric pressure which vacuums in circulation. The objective of this study was to compare negative pressure wound therapy (NPWT) versus surgical wounds healing by secondary intention (SWHSI). A systematic literature search was conducted using the PubMed and Scopus search engine up until the 20 Th January 2017 including the terms: "negative pressure wound therapy" and "pressure ulcers". In this systematic review, six randomized controlled trials were included. NPWT is deemed appropriate and effective method and widely used by clinicians to promote the healing of wounds and ulcers of different etiology. The heterogeneity found in individual trials regarding the inclusion criteria, therapeutic procedures, the criteria and methods of outcome evaluation, however, did not allow for a data evaluation with statistically valid conclusions. It is reasonable to assume that a subset of patients with pressure ulcers can be effectively treated with NPWT, with optimal results and good cost-benefit ratio, also with respect to the quality of life.

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“…II). [24][25][26][27][28][29] Quality assessment of the included studies. Since all the included studies are RCTs the quality assessment was based on the risk of bias.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Negative pressure wound therapy versus healing by secondary intention in pressure ulcers

Cirocchi¹,

G²,

Mutafchiyski³

et al. 2017

NPWTJ

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“…As well as preventing infection and decreasing the bacterial load, NPWT has demonstrated a wide variety of merits in the treatment of complex wound defects. Previous studies have reported that NPWT is able to decrease wound size, maintain a moist atmosphere for wound healing, reduce edema and assist with the closure of areas not fully closed in the wound, also termed dead cavities (8,22). Notably, microscopically NPWT is able to promote granulation, vascularization, epithelialization and the synthesis of fibrin within the wound (23,24).…”

Section: Discussionmentioning

confidence: 99%

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

Chen

et al. 2016

Oncology Letters

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Abstract. Major wound complications of the extremities, following wide tumor resection and reconstruction for soft-tissue sarcomas (STSs), remain a challenge for limb-sparing surgery. Furthermore, STSs with ulceration or impending ulceration predispose patients to an increased risk of post-operative infection. The present study was conducted to assess the efficacy of negative pressure wound therapy (NPWT) in preventing wound complications associated with surgical treatment of STSs with ulceration or impending ulceration, in patients treated between February 2012 and January 2013. A total of 5 patients, with a mean age of 48 years (range, 24-68 years), were enrolled in the present study. The diagnoses consisted of undifferentiated pleomorphic sarcoma (n=2), leiomyosarcoma (n=1), synovial sarcoma (n=1) and epithelioid sarcoma (n=1). According to American Joint Committee on Cancer criteria, 3 cases were stage III tumors, and the remaining 2 cases were of stages ⅡA and ⅡB, respectively. A total of 3 patients exhibited ulceration at diagnosis, and the remaining patients demonstrated impending ulceration. The mean wound area following wide resection of the tumor was 73 cm 2 (range, 45-110 cm 2 ). A continuous suction mode, with pressures measuring -200 to -300 mmHg, was used for 7-10 days on the soft-tissue defects as preparation for wound closure. Soft-tissue reconstruction included muscle flaps (n=2) and skin grafts (n=5). No major wound complications occurred. Post-operative functional and cosmetic outcomes were acceptable. A single patient demonstrated local recurrence 12 months after surgery and re-excision of the tumor was performed. All patients remained alive at the conclusion of follow-up, with a mean follow-up time of 26 months (range, 12-36 months). The present study demonstrated that NPWT is effective and safe when used as an adjunct to wound closure following resection of extremity STS with ulceration/impending ulceration.

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Negative pressure wound therapy for treating pressure ulcers

Dumville

Webster

Evans

et al. 2015

Cochrane Database of Systematic Reviews

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Faster wound healing with topical negative pressure therapy in difficult to heal wounds

Cited by 32 publications

References 0 publications

Negative pressure wound therapy versus healing by secondary intention in pressure ulcers

Negative pressure wound therapy versus healing by secondary intention in pressure ulcers

Use of negative pressure wound therapy as an adjunct to the treatment of extremity soft-tissue sarcoma with ulceration or impending ulceration

Negative pressure wound therapy for treating pressure ulcers

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