Faster lactate transport across red blood cell membrane in sickle cell trait carriers

Abstract

Fagnété, Sara, Connes Philippe, Hue Olivier, Montout-Hedreville Mona, Etienne-Julan Maryse, and Hardy-Dessources MarieDominique. Faster lactate transport across red blood cell membrane in sickle cell trait carriers.

Stiffening of sickle cell trait red blood cells under simulated strenuous exercise conditions

“…At lower pH, CDB3 becomes even more compact 30,37 , which can further enhance the binding and stiffening of SCT RBCs. In addition, monocarboxylate transporter 1 (MCT-1) activity has been speculated to impact RBC stiffness 38–40 . Because MCT-1 activity is inherently stronger in SCT RBCs than normal RBCs at low pH, the higher concentration of hydrogen ions leads to even stronger MCT-1 activity, and the enhancement of MCT-1 activity could also be responsible for the significant increase in shear modulus measured on SCT RBCs at pH 6.85.…”

Beyond Mechanical Tension: A Review of Resistance Exercise-Induced Lactate Responses & Muscle Hypertrophy

“…Although skeletal muscle tissue appears to be one of the primary sources for La − production and clearance during exercise, La − that is not metabolized in the skeletal muscle may end up in circulation (e.g., plasma) where some of the La − can be taken up via an MCT (e.g., MCT1) into red blood cells (RBC) as an intermediate step for transportation. Interestingly, La − transportation into RBC may reduce the levels of La − and H+ in the plasma, resulting in a larger gradient from interstitial fluid to plasma, which may positively influence the rate of release of these ions from exercising muscle tissue [ 70 , 71 ]. Once La − has entered circulation, it can be transported to various tissues such as the liver, heart, inactive and active skeletal muscles, and other tissues, including the brain [ 72 ].…”