Fast X-ray microfluorescence imaging with submicrometer-resolution integrating a Maia detector at beamline P06 at PETRA III

Boesenberg, Ulrike; Ryan, C.G.; Kirkham, R.; Dp, Siddons; Alfeld, Matthias; Garrevoet, Jan; Núñez, Tomás; Claußen, Thorsten; Kracht, T.; Falkenberg, Gerald

doi:10.1107/s1600577516015289

Cited by 49 publications

(50 citation statements)

References 52 publications

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“…Elements down to atomic number 15 (phosphorus) are detected. The integration of the detector system at the beamline P06 has been described elsewhere . Accurate positioning and motion control of the sample are achieved by an encoder‐controlled stage system providing 50 mm travel range with 20 nm precision.…”

Section: Methodsmentioning

confidence: 99%

“…In this paper, we propose a different method for the identification of trace minerals and metals in their undisturbed histological context. Unstained sections are imaged by fast‐scanning high‐resolution X‐ray fluorescence (XRF) analysis . XRF is a non‐destructive technique, and the same sample can subsequently be used for ultrastructural analysis by light microscopy (LM) or transmission electron microscopy (TEM), and also nanoscopic X‐ray analyses [X‐ray diffraction, X‐ray absorption near edge structure and scanning coherent diffraction imaging (ptychography)].…”

Section: Introductionmentioning

confidence: 99%

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Large‐scale high‐resolution micro‐XRF analysis of histological structures in the skin of the pigeon beak

et al. 2017

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Histological analysis of biological structures in the avian beak is performed by means of large-scalehigh-resolutionmicro-Xray fluorescence analysis using a Maia detector system. Element maps of S, K, Ca, Fe and Zn of square millimeter sizes show distinct cellular and subcellular tissue structures in semi-thin sections with a resolution at the (sub-)micrometer scale. Non-destructive qualitative and quantitative evaluation of the respective trace elements can be performed on the tissue samples. The elemental maps are compared with conventional differential histological stainings of parallel sections. This method is discussed as a pre-examination tool for subsequent analysis of selected structural sites by diffractive and spectroscopic X-ray nanoprobe techniques and, after additional ultrasectioning, also by transmission electron microscopy.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Large‐scale high‐resolution micro‐XRF analysis of histological structures in the skin of the pigeon beak

et al. 2017

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“…The general setup with the Maia detector mounted in backscattering geometry at the microfocus endstation of the P06 beamline is described in detail elsewhere (Boesenberg et al, 2016). A schematic of the setup at the beamline is shown in Fig.…”

Section: à4mentioning

confidence: 99%

“…The experiments were conducted in fluorescence mode with a sub-micrometer focused beam scanning the sample in two dimensions using a Maia detector at the P06 beamline, PETRA III, Deutsches Elektronen-Synchrotron (DESY), Germany (Boesenberg et al, 2016). The set-up was characterized with a specially designed Ta/Ta 2 O 5 test pattern and a geological thin section, directly comparing conventional measurements with the energy as the outer axis with fast XANES results with the energy as the inner scanned axis.…”

Section: Introductionmentioning

confidence: 99%

Fast XANES fluorescence imaging using a Maia detector

Boesenberg¹,

Ryan²,

Kirkham³

et al. 2018

J Synchrotron Radiat

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A new fast X-ray absorption spectroscopy scanning method was recently implemented at the Hard X-ray Microprobe endstation P06, PETRA III, DESY, utilizing a Maia detector. Spectromicroscopy maps were acquired with spectra for X-ray absorption near-edge structure (XANES) acquisition in the subsecond regime. The method combines XANES measurements with rasterscanning of the sample through the focused beam. The order of the scanning sequence of the axes, one beam energy axis and two (or more) spatial axes, is a variable experimental parameter and, depending on it, the dwell at each location can be either single and continuous (if the energy axis is the inner loop) or in shorter discontinuous intervals (if a spatial axis is innermost). The combination of improved spatial and temporal resolution may be necessary for rapidly changing samples, e.g. for following in operando chemical reactions or samples highly susceptible to beam damage where the rapid collection of single XANES spectra avoids issues with the emergence of chemical changes developing from latent damage. This paper compares data sets collected on a specially designed test pattern and a geological thin-section scanning the energy as inner, middle and outer axis in the sequence. The XANES data of all three scanning schemes is found to show excellent agreement down to the single-pixel level.

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“…Now two Maia 384 detectors are in routine application at the XFM beamline [7], one for µm-scale mapping and one for macro-scale mapping of cultural heritage objects. Maia 384 detectors are also in use for SXRF element mapping at the P06 beamline, Petra III synchrotron, DESY in Hamburg [8], the SRX beamline, NSLS-II in New York and the CHESS synchrotron at Cornell University. The large solid-angle and collection efficiency of the Maia 384 detector has been exploited in a pair of laboratory XRF mapping systems called Maia Mapper at CSIRO for high definition element mapping of rock samples and drill core at 30 µm spatial resolution over spatial scales up to 500 mm [9].…”

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confidence: 99%

The Maia Detector Journey: Development, Capabilities and Applications

et al. 2018

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The development of the Maia detector was motivated by the desire for high throughput synchrotron fluorescence element mapping with images beyond 100 M pixels, which capture both fine detail and extended spatial context. It achieves this by using a large planar silicon detector array together with event-mode data acquisition, where each detected X-ray event is tagged with position in the scan, thus avoiding the readout overheads of a "step and acquire" style of mapping. The sample stage moves continuously and the stage encoders are read by the FPGA based real-time processor to provide coordinates for each event, which provides great freedom in scan speed or transit time per map pixel [1]. The large detector array, with 384 independent detector channels, each with its own charge amplification and pulse capture electronics, implemented using custom ASICs, enables cumulative count-rates exceeding 10 M/s to be achieved with low pile-up probability, which enables adequate counting statistics to be acquired per pixel in transit times as short as 50 µs [2,3]. The array uses a back-scatter, annular configuration, which combines a 1.3 sr solid-angle detection geometry with complete freedom in sample size and scanning range. This has enabled applications to extend from the initial focus on synchrotron X-ray microanalysis, with µm sized pixels and scan ranges up to a few centimeters, to macro-scale mapping using synchrotron or laboratory X-ray sources, with scan ranges up to ~1 m. Synchrotron XRF mapping using Maia has been applied to studies in the earth, planetary, environmental, medical, biological, chemical and material sciences as well as cultural heritage (see refs cited in [1]). Methods and quantitative imaging techniques developed for Maia, which exploit event acquisition tagged by two or three axis coordinates, include large area, high definition, high throughput

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Fast X-ray microfluorescence imaging with submicrometer-resolution integrating a Maia detector at beamline P06 at PETRA III

Cited by 49 publications

References 52 publications

Large‐scale high‐resolution micro‐XRF analysis of histological structures in the skin of the pigeon beak

Large‐scale high‐resolution micro‐XRF analysis of histological structures in the skin of the pigeon beak

Fast XANES fluorescence imaging using a Maia detector

The Maia Detector Journey: Development, Capabilities and Applications

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