Fast voluntary neck movements in patients with cervical dystonia: A kinematic study before and after therapy with botulinum toxin type A

Gregori, B.; Agostino, Rocco; Bologna, Matteo; Dinapoli, Loredana; Colosimo, Carlo; Accornero, N.; Berardelli, Alfredo

doi:10.1016/j.clinph.2007.10.007

Cited by 40 publications

(41 citation statements)

References 26 publications

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“…When they underwent the VBM studies, all the patients with CD were under optimal treatment with botulinum toxin, a therapy that significantly improves the severity of the involuntary neck movements. 4,29,30 …”

Section: Discussionmentioning

confidence: 99%

“…These findings are now increasingly challenged by studies using advanced neuroimaging techniques detecting abnormalities in brain areas that may be functionally involved in the pathophysiology of dystonia. 3,4 Cross-sectional studies using MR imaging-VBM, a technique that can evaluate intergroup and intragroup voxel-wise differences in GM volumes, have detected ultrastructural brain changes in apparently normal brain tissue in patients with CD. [5][6][7] In these patients, regional GM abnormalities have been described in both subcortical and cortical structures, though controversial findings have been reported by the various authors.…”

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confidence: 99%

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A Transverse and Longitudinal MR Imaging Voxel-Based Morphometry Study in Patients with Primary Cervical Dystonia

Pantano¹,

Totaro

Fabbrini

et al. 2010

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A Transverse and Longitudinal MR Imaging Voxel-Based Morphometry Study in Patients with Primary Cervical Dystonia

Pantano¹,

Totaro

Fabbrini

et al. 2010

AJNR Am J Neuroradiol

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“…The dystonic activities in these four superficial muscles could be objectively determined by physical exam and measurement of rotation angle, which were used as the gold standard in this study because they are considered the current best practical diagnostic tests to evaluate superficial cervical muscles in PCD [1,[8][9][10][11][12].…”

Section: Determination Of Dystonic Superficial Cervical Musclesmentioning

confidence: 99%

“…However, deep cervical muscles may be beyond reach with a conventional 37-mm needle electrode for EMG [8]. Also, the use of motion analysis systems has allowed the extraction of kinematics parameters in a quantitative and reliable way [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Comparison between 18F-FDG PET/CT and EMG Mapping for Identifying Dystonic Superficial Muscles in Primary Cervical Dystonia: Preliminary Results

Jang

Choi

Sung

et al. 2010

Nucl Med Mol Imaging

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Purpose This study was conducted to compare 18 F-FDG PET/CT and electromyography (EMG) mapping in patients with primary cervical dystonia (PCD) to find dystonic superficial cervical muscles. Methods Ten consecutive patients with PCD (M:F=5:5, age 44±13 years) whose dystonic posture was not relieved with conventional muscle relaxant therapy were included. Target cervical muscles for the comparison between 18 F-FDG PET/CT and EMG mapping were four representative superficial bilateral cervical muscles: splenius capitis muscle, sternocleidomstoid muscle, upper trapezius muscle, and leavator scapulae muscle. The diagnostic efficacy was compared between 18 F-FDG PET/CT and EMG mapping using physical exam and measurement of rotation angle as the gold standard. Results Among 80 muscles evaluated, there were 21 (26%) dystonic superficial cervical muscles assessed with physical exam and motion analysis. The sensitivity, specificity, and accuracy for localizing dystonic muscles were 76, 92, and 88% for 18 F-FDG PET/CT, and 95, 66, and 74% for EMG mapping, respectively. The sensitivity of EMG mapping was significantly higher than that of 18 F-FDG PET/CT. In contrast, 18 F-FDG PET/CT was significantly superior to EMG mapping for specificity and accuracy. Conclusions 18 F-FDG PET/CT is more specific and accurate than EMG mapping for finding superficial dystonic cervical muscles. The high sensitivity of EMG mapping suggests that 18 F-FDG PET/CT and EMG mapping are complementary for finding dystonic superficial cervical muscles.

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“…37 Within the neurological domain, CM is the most elaborated outcome measure in patients with cervical dystonia, before and after therapy with botulinum toxin type A. 38 Because CM is volitionally controlled, its assessment depends on full patient collaboration. In determination of the degree of impairment, the question whether the patient is indeed putting a maximal effort is therefore of paramount importance, particularly when other objective findings are difficult to obtain.…”

Section: Use Of CM As An Outcome Measurementioning

confidence: 99%

Cervical Motion Testing: Methodology and Clinical Implications

Prushansky¹,

Dvir²

2008

Journal of Manipulative and Physiological Therapeutics

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Fast voluntary neck movements in patients with cervical dystonia: A kinematic study before and after therapy with botulinum toxin type A

Cited by 40 publications

References 26 publications

A Transverse and Longitudinal MR Imaging Voxel-Based Morphometry Study in Patients with Primary Cervical Dystonia

A Transverse and Longitudinal MR Imaging Voxel-Based Morphometry Study in Patients with Primary Cervical Dystonia

Comparison between 18F-FDG PET/CT and EMG Mapping for Identifying Dystonic Superficial Muscles in Primary Cervical Dystonia: Preliminary Results

Cervical Motion Testing: Methodology and Clinical Implications

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