Fast T2 mapping of the patellar articular cartilage with gradient and spin-echo magnetic resonance imaging at 1.5 T: validation and initial clinical experience in patients with osteoarthritis

Quaia, Emilio; Toffanin, Renato; Guglielmi, Giuseppe; Ukmar, Maja; Rossi, Alexia; Martinelli, Bruno; Cova, Maria Assunta

doi:10.1007/s00256-008-0478-8

Cited by 28 publications

(27 citation statements)

References 27 publications

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“…Our current study in some ways is similar to theirs, although a valid comparison cannot be undertaken due to major differences in the MRI technique (an ultra-high-field whole-body system at 7T in the Welsch et al (18) study vs. a standard clinical 1.5T scanner in ours). In another study by Quaia et al (19) a technique of fast T 2 mapping was reported and T 2 values derived from MR spectroscopy were compared to turbo spin-echo (TSE) and gradient-spin-echo (GRASE) MRI-derived T 2 values at 1.5T for patellar cartilage evaluation in 35 patients. Their study demonstrated a good correlation between T 2 values using GRASE and TSE.…”

Section: Discussionmentioning

confidence: 99%

“…The MRI examination consisted of two parts (MRI precontrast, MRI postcontrast). The first part was the precontrast protocol that included a 3D GRE sequence (multiecho data image combination [MEDIC]) with six echoes in order to assess a T* 2 map: repetition time (TR) ϭ ϳ28 ms, echo time (TE) ϭ 4.68 ms, 8.82 ms, 12.96 ms, 17.10 ms, 21.24 ms, and 25.38 ms, flip angle (FA) ϭ 25, bandwidth (BW) ϭ 260 kHz, number of excitations (NEX) ϭ 3, slice thickness ϭ 0.78 mm, slice gap ϭ 100%, field-of-view (FOV) ϭ 200 mm, matrix size ϭ 256 ϫ 256, number of sections ϭ 96, and TA ϭ 8 min 3 s. T* 2 maps were assessed inline using a nonlinear least squares fitting routine (19). In the second part involving indirect MR arthrography and dGEMRIC, 0.4 ml/kg body weight of gadolinium contrast agent (Magnevist; Schering AG, Berlin, Germany) was administered intravenously.…”

Section: Mrimentioning

confidence: 99%

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Feasibility of T mapping for the evaluation of hip joint cartilage at 1.5T using a three‐dimensional (3D), gradient‐echo (GRE) sequence: A prospective study

Bittersohl¹,

Hosalkar²,

Hughes³

et al. 2009

Magnetic Resonance in Med

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This study defines the feasibility of utilizing three-dimensional (3D) gradient-echo (GRE) MRI at 1.5T for T* 2 mapping to assess hip joint cartilage degenerative changes using standard morphological MR grading while comparing it to delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). MRI was obtained from 10 asymptomatic young adult volunteers and 33 patients with symptomatic femoroacetabular impingement (FAI). The protocol included T* 2 mapping without gadolinium-enhancement utilizing a 3D-GRE sequence with six echoes, and after gadolinium injection, routine hip sequences, and a dual-flipangle 3D-GRE sequence for dGEMRIC T 1 mapping. Cartilage was classified as normal, with mild changes, or with severe degenerative changes based on morphological MRI. T 1 and T* 2 findings were subsequently correlated. There were significant differences between volunteers and patients in normally-rated cartilage only for T 1 values. Both T 1 and T* 2 values decreased significantly with the various grades of cartilage damage. There was a statistically significant correlation between standard MRI and T* 2 (T 1 ) (P < 0.05). High intraclass correlation was noted for both T 1 and T* 2 . Correlation factor was 0.860 to 0.954 (T* 2 -T 1 intraobserver) and 0.826 to 0.867 (T* 2 -T 1 interobserver). It is feasible to gather further information about cartilage status within the hip joint using GRE T* 2 mapping at 1.5T. Magn Reson Med 62:896 -901, 2009.

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Section: Discussionmentioning

confidence: 99%

Section: Mrimentioning

confidence: 99%

Feasibility of T mapping for the evaluation of hip joint cartilage at 1.5T using a three‐dimensional (3D), gradient‐echo (GRE) sequence: A prospective study

Bittersohl¹,

Hosalkar²,

Hughes³

et al. 2009

Magnetic Resonance in Med

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“…Quaia et al [8] found that gradient and spin-echo sequence (GRASE) provided T2 values slightly lower than those obtained by TSE sequence in most patients (mean difference ± SD, 1.81 ± 3.63 ms). This difference may be due to the presence of T2* decay in the GRASE sequence.…”

Section: Discussionmentioning

confidence: 99%

“…The available mappings for cartilage tissue are T1 mapping, T2 mapping and T2-star (T2*) mapping but the most commonly used is T2 mapping which can evaluate the status of the cartilage matrix and identify biochemical changes associated with the early stages of OA [8,9]. Several studies have demonstrated that T2 mapping is useful for the detection of early stages of matrix degeneration [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

MRI T2 Mapping of Knee Articular Cartilage Using Different Acquisition Sequences and Calculation Methods at 1.5 Tesla

Mars¹,

Chelli²,

Tbini³

et al. 2018

Med Princ Pract

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Objective: This study aims to determine how magnetic resonance imaging (MRI) acquisition techniques and calculation methods affect T2 values of knee cartilage at 1.5 tesla and to identify sequences that can be used for high-resolution T2 mapping in short scanning times. Materials and Methods: This study was performed on phantom and 29 patients who underwent MRI of the knee joint at 1.5 tesla. The protocol includes T2 mapping sequences based on Single-Echo Spin Echo (SESE), Multi-Echo Spin Echo (MESE), Fast Spin Echo (FSE) and Turbo Gradient Spin Echo (TGSE). The T2 relaxation times were quantified and evaluated using three calculation methods (MapIt, Syngo Offline and mono-exponential fit). signal-to-noise ratios (SNR) were measured in all sequences. All statistical analyses were performed using the t-test. Results: The average T2 values in phantom were 41.7 ± 13.8 ms for SESE, 43.2 ± 14.4 ms for MESE, 42.4 ± 14.1 ms for FSE and 44 ± 14.5 ms for TGSE. In the patient study, the mean differences were 6.5 ± 8.2 ms, 7.8 ± 7.6 ms and 8.4 ± 14.2 ms for MESE, FSE and TGSE compared to SESE, respectively; these statistical results were not significantly different (p > 0.05). The comparison between the three calculation methods showed no significant difference (p > 0.05). The t-test showed no significant difference between SNR values for all sequences. Conclusion: T2 values depend not only on the sequence type but also on the calculation method. None of the sequences revealed significant differences compared to the SESE reference sequence. TGSE with its short scanning time can be used for high-resolution T2 mapping.

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“…The feasibility of the proposed approach was assessed on 35 patients (21 males and 14 females) with moderate degree of patellar osteoarthritis. (Quaia et al, 2008).…”

Section: Fast T2 Mapping Of the Patellar Articular Cartilagementioning

confidence: 99%

Fast MRI Methods for the Clinical Evaluation of Skeletal Disorders

Toffanin¹,

Guglielmi²,

Cova³

2011

Medical Imaging

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Fast T2 mapping of the patellar articular cartilage with gradient and spin-echo magnetic resonance imaging at 1.5 T: validation and initial clinical experience in patients with osteoarthritis

Abstract: Fast T2 mapping of the patellar articular cartilage can be performed with GRASE within a third of the time of that of standard sequences.

Cited by 28 publications

References 27 publications

Feasibility of T mapping for the evaluation of hip joint cartilage at 1.5T using a three‐dimensional (3D), gradient‐echo (GRE) sequence: A prospective study

Feasibility of T mapping for the evaluation of hip joint cartilage at 1.5T using a three‐dimensional (3D), gradient‐echo (GRE) sequence: A prospective study

MRI T2 Mapping of Knee Articular Cartilage Using Different Acquisition Sequences and Calculation Methods at 1.5 Tesla

Fast MRI Methods for the Clinical Evaluation of Skeletal Disorders

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