Fast-spiking interneurons of the premotor cortex contribute to action planning

Giordano, Nadia; Alia, Claudia; Fruzzetti, Lorenzo; Pasquini, Maria; Mazzoni, Annalisa; Micera, Silvestro; Fogassi, Leonardo; Bonini, Luca; Caleo, Matteo

doi:10.1101/2021.05.14.443822

“…Although we might expect that activation of vmPFC PV neurons would release reactive behaviors such as freezing by suppressing vmPFC outputs, the relationship between PV and pyramidal neuron firing is complex. Cortical PV neurons have been reported to activate simultaneously with local pyramidal neurons (Estebanez et al, 2017;Giordano et al, 2021;Isomura et al, 2009;Merchant et al, 2008;Nashef et al, 2020;Okun and Lampl, 2008;Pinto and Dan, 2015), and it has been suggested that PV neurons may help to shape, rather than gate, the firing of local pyramidal neurons (Isomura et al, 2009;Merchant et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Infralimbic parvalbumin neural activity facilitates cued threat avoidance

Ho,

Yang,

Boddu

et al. 2023

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0

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The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors — such as freezing or flight — are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions.

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Infralimbic parvalbumin neural activity facilitates cued threat avoidance

Ho,

Yang,

Boddu

et al. 2024

Preprint

0

View full text Add to dashboard Cite

The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions.

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Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance

Ho,

Yang,

Boddu

et al. 2023

Preprint

0

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The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions.

show abstract

Fast-spiking interneurons of the premotor cortex contribute to action planning

Cited by 3 publications

References 53 publications

Infralimbic parvalbumin neural activity facilitates cued threat avoidance

Infralimbic parvalbumin neural activity facilitates cued threat avoidance

Infralimbic parvalbumin neural activity facilitates cued threat avoidance

Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance

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