Fast speciation analysis of iodophenol compounds in river waters by capillary electrophoresis‐inductively coupled plasma‐mass spectrometry with off‐line solid‐phase microextraction

Abstract

An analytical methodology for the fast separation and determination of iodophenol species in natural water samples was developed using capillary electrophoresis (CE) coupled to inductively coupled plasma-mass spectrometry (ICP-MS). Based on the element-specific and highly sensitive detection provided by ICP-MS, the methodology has been applied to the analysis of 2-iodophenol, 4-iodophenol, and 2,4,6-triiodophenol. The use of solid-phase microextraction (SPME), after proper optimization, improved the signal by a factor of 100 leading to detection limits in the sub microg.L(-1). Different desorption conditions of iodophenol compounds from the SPME microfiber were studied to achieve the optimum preconcentration factor and best analytical performance. Different CE conditions were studied to achieve complete baseline separation of iodophenols in short migration times. Three different CE buffer systems were evaluated using ICP-MS detection. A buffer solution containing 20 mmol.L(-1) 3-(cyclohexylamino)-1-propanesulfonic acid (CAPS) and an applied potential of +22 kV were finally selected leading to a maximum separation time of 6.6 min. A relative standard deviation (%RSD) of about 5.0% for ten consecutive determinations was obtained. Finally, the speciation methodology developed was utilized for the determination of iodophenol compounds in natural water samples.

Quantitation in capillary electrophoresis-mass spectrometry

“…For an introduction [10] and [39] are recommended readings. Peak area RSD% values between 9.9 and 16.5% (n = 5) for metallothionein [40], 5.0% (n = 10) for iodophenols [41], and 3.5-6.2% (n = 8) for arsenic compounds [42] were obtained with this method.…”

Recent advances in the application of capillary electrophoresis with mass spectrometric detection

“…The proposed procedure allowed the identification of several inorganic and organic manganese species in the investigated tissue. Iodine disinfection by-products, in particular iodphenols, were determined in river water by Kannamkumarath et al [194]. Their method involves offline SPME followed by analysis of the extracts using CE coupled to ICP-MS. Sulfur containing amino acids were investigated employing CE-ICP-MS with a dynamic reaction cell by Yeh et al [195].…”

Analysis of drugs, natural and bioactive compounds containing phenolic groups by capillary electrophoresis coupled to mass spectrometry

“…Kannamkumarath et al [108] established an analytical methodology for the fast separation and determination of iodophenol species in natural water samples using capillary electrophoresis (CE) coupled to ICP-MS. Based on the element-specific and highly sensitive detection provided by ICP-MS, the methodology has been applied to the analysis of 2-iodophenol, 4-iodophenol, and 2,4,6-triiodophenol. The use of solid-phase microextraction (SPME), after proper optimization, improved the signal by a factor of 100 leading to detection limits in the sub mg?L…”