Fast Solvating Gas Chromatography of Environmentally Important Compounds Using Polymer-Encapsulated Silica Particles

Wu, Nan; Shen, Yi; Lee, Milton L.

doi:10.1002/(sici)1521-4168(19991001)22:10<541::aid-jhrc541>3.0.co;2-q

Cited by 5 publications

References 27 publications

(11 reference statements)

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Fast chiral separations using packed capillary columns and near-critical fluid carbon dioxide mobile phase

Chen

Medina

et al. 2000

J. Micro. Sep.

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In this study, fast chiral separations were demonstrated using near‐critical carbon dioxide as mobile phase. Most separations were carried out in less than 1 min at 30°C using 12–15 cm capillary columns packed with 5 μm porous (300 Å) silica particles deactivated with 3‐cyanopropyldimethylchlorosilane and encapsulated with cyclodextrin‐substituted polymethylsiloxane. The fastest separation was accomplished in 36 s. Effects of surface deactivation, temperature, pressure, and restrictor internal diameter on performance were investigated. Results show that 3‐cyanopropyldimethylchlorosilane was a better deactivation reagent than polymethylhydrosiloxane. Near‐critical fluid chromatography, which is classified along with supercritical fluid chromatography (SFC) in this paper, is more suitable for fast separation of enantiomers than open tubular column gas chromatography (GC). SFC can be performed under low temperatures and high pressures, which allow high selectivity and high speed. Temperature had a significant effect on retention factor, selectivity, resolution, and resolution per unit time. Pressure had little effect on selectivity but had a considerable effect on retention factor and resolution. Finally, dimensions of the linear restrictor (in other words, the pressure at the end of the column) had a significant influence on speed and resolution. © 2000 John Wiley & Sons, Inc. J Micro Sep 12: 454–461, 2000

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Fast chiral separations using packed capillary columns and near-critical fluid carbon dioxide mobile phase

Chen

Medina

et al. 2000

J. Micro. Sep.

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Packed capillary column solvating gas chromatography using neat water mobile phase and flame ionization detection

Wu¹,

Tang²,

Lippert³

et al. 2001

J Microcolumn Separations

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Neat water at temperatures above its normal boiling point was used as a mobile phase for packed capillary column chromatography. The ''universal'' Ž . flame ionization detector FID was used for detection. No restrictor or back pressure was imposed at the column outlet. The effects of temperature on column efficiency and retention were investigated using particle-bonded continuous bed columns packed and crosslinked with 3 m polybutadiene-encapsulated zirconia particles. It was found that when the column inlet pressure was held constant and the temperature was increased to values that were higher than 100ЊC, the pressure drop decreased rapidly, allowing the use of long columns or small particles. Solute retention factors decreased with increasing temperature; however, column inlet pressure had little effect on retention factor. Mass transfer resistance also decreased with an increase in temperature. Mixtures of alcohols and phenols could be separated within several minutes after the interface between the column and the FID was optimized.

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Supercritical Fluid Chromatography

Poole

2003

The Essence of Chromatography

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Fast Solvating Gas Chromatography of Environmentally Important Compounds Using Polymer-Encapsulated Silica Particles

Cited by 5 publications

References 27 publications

Fast chiral separations using packed capillary columns and near-critical fluid carbon dioxide mobile phase

Fast chiral separations using packed capillary columns and near-critical fluid carbon dioxide mobile phase

Packed capillary column solvating gas chromatography using neat water mobile phase and flame ionization detection

Supercritical Fluid Chromatography

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