Fast RPLC-UV method on short sub-two microns particles packed column for the assay of tenoxicam in plasma samples

Sora, Iulia; Galaon, Toma; Udrescu, Stefan; Negru, Jean; David, Víctor; Medvedovici, Andrei

doi:10.1016/j.jpba.2006.11.008

Cited by 14 publications

(6 citation statements)

References 25 publications

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“…Carbon load is generally associated with increased retention and separation of hydrophobic compounds. High sensitivity was provided by the 3.0‐µm particle size (narrow, high‐efficiency peaks) and also by the reduced column inner diameter of 2.0 mm (Sora et al 2007; Galaon et al 2008).…”

Section: Resultsmentioning

confidence: 99%

Occurrence and Fate of Bisphenol A and its Congeners in Two Wastewater Treatment Plants and Receiving Surface Waters in Romania

Chiriac

Păun

Pirvu

et al. 2020

Enviro Toxic and Chemistry

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The present study investigated the distribution and environmental fate of Bisphenol A (BPA), the 4‐hydroxyacetophenone (4‐HAP) metabolite, and 5 other bisphenol congeners in 2 municipal wastewater treatment plants (WWTPs) and their receiving rivers in Romania. Accordingly, a new, highly sensitive and accurate solid‐phase extraction–liquid chromatography–electrospray ionization–tandem mass spectrometry method was developed and validated. This technique generated low limit of quantitation values: below 2.3 ng/L for surface water and less than 2.4 and 2.7 ng/L for WWTP effluent and influent water. The sum of detected analytes in wastewater was between 1337 and 16 118 ng/L for influent samples and between 15 and 96 ng/L for effluent samples. In surface water, the total of all compounds was somewhere between 34 and 240 ng/L. The highest concentration observed was for BPA in all 3 types of analyzed water (up to 9140 ng/L for influent, as high as 75 ng/L for effluent, and a maximum of 135 ng/L in surface waters). All analyzed samples were free of bisphenols B, C, and F. For all analytes detected in surface water, the concentration values were higher than those determined in the effluent samples, which may be caused by intrinsic contamination of the 2 rivers (Danube and Jiu Rivers). Values of environmental risk coefficients, calculated for both effluents and surface waters, indicated a low ecological risk or no ecological risk for 3 types of organisms (algae, daphnia, and fish). Human risk assessment calculation suggests no risk to human health as a result of the presence of BPA in either of the 2 rivers. Environ Toxicol Chem 2021;40:435–446. © 2020 SETAC

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Section: Resultsmentioning

confidence: 99%

Occurrence and Fate of Bisphenol A and its Congeners in Two Wastewater Treatment Plants and Receiving Surface Waters in Romania

Chiriac

Păun

Pirvu

et al. 2020

Enviro Toxic and Chemistry

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“…It shows a strong inhibitory effect in vitro on human metalloproteinase (stromelysin and collagenase) enzymes that stimulate cartilage destruction. 1 In the literature, high performance liquid chromatography, [2][3][4][5][6][7] thin layer chromatography, 8 flow injection spectrophotometric analysis, [9][10][11] and spectrophotometric and spectrofluorimetric methods [12][13][14][15] are reported as methods for the determination of TX in pharmaceuticals and biological samples. These methods require mostly time-consuming sample preparation procedures such as extraction and the costly instrumentation makes their usage inconvenient.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical Determination of the Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms

Ağın

Atal

2019

tjps

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Non-steroidal antienflamatuvar ilaç etken maddesi tenoksikamın (TX) elektro-oksidasyon davranışı çok duvarlı karbon nanotüple (MWCNT) modifiye edilmiş camsı karbon elektrot (GCE) ile dönüşümlü voltametri, diferansiyel puls voltametri (DPV) ve kare dalga voltametri (SWV) ile çalışılmıştır. Gereç ve Yöntemler: GCE, TX'in voltametrik metodlarla hassas tayini için MWCNT ile modifiye edilmiştir. Bulgular: Potansiyel pozitif yönde tarandığında TX'in pik akımı 0.520 V civarında DPV ile, 0.570 V civarında SWV ile oluşmuştur. TX'in oksidasyon prosesi tersinmez ve diffüzyon kontrollü davranış göstermiştir. DPV ve SWV için doğrusal cevaplar sırasıyla 2×10-7-1×10-5 M, 1.43×10-9 M yakalama alt sınırı (LOD) ile, 8×10-9-8×10-6 M, 9.97×10-10 M LOD ile 1 M asetat tamponu pH 5.5 içinde elde edilmiştir. Sonuç: Tamamen valide edilmiş DPV ve SWV başarılı bir şekilde TX'in farmasötik dozaj formundan miktar tayini için uygulanmış ve memnun edici sonuçlar elde edilmiştir.

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“…It indicates strong inhibitory effect in vitro on human metalloproteinase (stromelysin and collagenase) enzymes that stimulate cartilage destruction. 1 In literature, high performance liquid chromatography (HPLC), [2][3][4][5][6][7] thin layer chromatography (TLC), 8 flow injection spectrophotometric analysis, [9][10][11] spectrophotometric and spectrofluorimetric methods [12][13][14][15] are reported as the methods for determination of TX in pharmaceuticals and biological samples. These methods require mostly time-consuming sample preparation procedures such as extraction and costly instrumentation makes their usage inconvenient.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical Determination of Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms

Ağın¹,

Atal²

2018

tjps

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The electro-oxidation behavior of nonsteroidal anti-inflammatory drug tenoxicam (TX) was studied on multiwalled carbon nanotubes (MWCNTs) modified glassy carbon electrode (GCE) by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV). GCE was modified with MWCNTs for sensitive determination of TX with voltammetric methods. The current peaks for TX occurred at around 0.520 V for DPV and 0.570 V for SWV when the potential was scanned in the positive direction. The oxidation process of TX has shown irreversible and diffusion controlled behavior. The linear responses have been obtained in the range from 2 × 10 -7 to 1 × 10 -5 M with the limit of detection (LOD)1.43 × 10 -9 for DPV and from 8 × 10 -9 to 8 × 10 -6 with the LOD 9.97 × 10 -10 for SWV in 1 M acetate buffer solution at pH 5.5. Fully validated DPV and SWV were successfully applied for the determination of TX from pharmaceutical dosage form and obtained satisfying results. Özet: Nonsteroidal antienflamatuvar ilaç etken maddesi tenoksikamın (TX) elektrooksidasyon davranışı çok duvarlı karbon nanotüple (MWCNTs) modifiye edilmiş camsı karbon elektrot (GCE) ile dönüşümlü voltametri (CV), diferansiyel puls voltametri (DPV) ve kare dalga voltametri (SWV) ile çalışıldı. Camsı karbon elektrot, TX'in voltametrik metodlarla hassas tayini için MWCNTs ile modifiye edildi. Potansiyel pozitif yönde tarandığında TX'in pik akımı 0.520 V civarinda DPV ile, 0.570 V civarında SWV ile oluştu. TX'in oksidasyon prosesi tersinmez ve difüzyon kontrollü davranış gösterdi. DPV ve SWV için doğrusal cevaplar sırasıyla 2 × 10 -7 -1 × 10 -5 M, 1.43 × 10 -9 M yakalama alt sınırı (YAS) ile, 8 × 10 -9 -8 × 10 -6 M, 9.97 × 10 -10 M YAS ile 1 M asetat tamponu pH 5.5 içinde elde edildi. Tamamen valide edilmiş DPV ve SWV başarılı bir şekilde TX'in farmasötik dozaj formundan miktar tayini için uygulandı ve memnun edici sonuçlar elde edildi.

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Fast RPLC-UV method on short sub-two microns particles packed column for the assay of tenoxicam in plasma samples

Cited by 14 publications

References 25 publications

Occurrence and Fate of Bisphenol A and its Congeners in Two Wastewater Treatment Plants and Receiving Surface Waters in Romania

Occurrence and Fate of Bisphenol A and its Congeners in Two Wastewater Treatment Plants and Receiving Surface Waters in Romania

Electroanalytical Determination of the Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms

Electroanalytical Determination of Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms

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