To avoid affecting the highly efficient photoelectric conversion of the solar cells, the moisture content of the production workshop should be less than 1 ppm. The preparation of lithium-ion batteries, organic light-emitting devices, optical fibers, and supercapacitors requires humidity conditions of <0.1 ppm. In addition, power transmission (which requires insulating/ anhydrous gas), aviation exploration, and scientific research involve monitoring/ identifying the trace levels of moisture. [3,4] Therefore, the development of technologies or products that can accurately detect and indicate ultralow (<100 ppm) or extremely low (<1 ppm) humidity is of great practical significance.Currently, only semiconductor capacitive sensors based on special crystal forms (i.e., γ-Al 2 O 3 ) and mirror-based dew point hygrometers can achieve accurate detection of ultralow or trace amounts of moisture, with thresholds of 1 ppm and −100 °C of dew point (i.e., 0.01 ppm), respectively. [5,6] However, owing to the complex and harsh manufacturing of core materials and the extremely high requirements for instrument components (such as high-quality mirror surfaces, high-precision temperature control systems and high-sensitivity dewdrop and ice crystal optical detection systems), these instruments are bulky, extremely expensive and require complex external power supply systems or coupling circuits, significantly limiting their widespread application. As an alternative, color-visualized waterresponsive materials offer a simple, low-cost, portable and easy-to-read method for humidity sensing and detection. They provide a direct visual way to convert environmental water vapor stimuli into a naked eye readout color by incorporating humidity-responsive chromic components into a solid support, and the resulting visual humidity sensor can be adapted to different environmental conditions. Thus far, various novel systems/strategies have been developed for visual humidity sensors, including inorganic materials (e.g., cobalt/nickel halides, [7,8] perovskites, [9] and nanocrystals [10] ), photonic bandgap structure materials, [11][12][13][14][15] aggregation discoloration dyes, [16][17][18][19] metal dynamic coordination systems, [20] polaritysensitive fluorescent materials, [21] redox [22] and acid-base [23] color-changing dye switches. These efforts have significantlyThe detection and monitoring of ultralow humidity (<100 ppm) are critical in many important industries, such as high-tech manufacturing, scientific research, and aerospace. However, the development of ppm level humidity sensors with portability, low cost, and ease of regeneration remains a significant challenge. Herein, an innovative "enzyme-like" construction strategy is proposed to address this problem by employing suitable molecular-level humidity-sensitive units and chemically constructing a multilevel spatial synergistic sensitization microenvironment around it. The as-prepared ultralow humidity-sensitive paper (UHSP) achieved a naked eye recognition humidity of 0.01-100 ppm....