Fast reaction of irradiated polymers—I. Crosslinking and degradation of polyvinylpyrrolidone

Rosiak, Janusz M.; Olejniczak, Jason; Pȩkala, W.

doi:10.1016/1359-0197(90)90173-f

Cited by 22 publications

(22 citation statements)

References 9 publications

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“…PVP-derived radicals undergo subsequent reactions of recombination, disproportionation, H-transfer, fragmentation, etc [19,[42][43][44]. Some of them are of practical importance; intermolecular recombination of radiation-generated PVP radicals leading to crosslinking and ultimately to gel formation is the basis of industry-implemented radiation technology for manufacturing hydrogel dressings used in burn wound healing [45][46][47].…”

Section: Generation Of • Oh Radicalsmentioning

confidence: 99%

Reaction of a low‐molecular‐weight free radical with a flexible polymer chain: Kinetic studies on the OH + poly(N‐vinylpyrrolidone) model

Bartoszek

Ulański

Rosiak

2011

Int J of Chemical Kinetics

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This work addresses the issue of kinetics of diffusion-controlled reactions of small radicals with macromolecules in solution. Attack of pulse-generated hydroxyl radicals on poly(N-vinylpyrrolidone)-PVP-chains of various molecular weight in water was used as the model reaction. Pulse radiolysis with spectrophotometric detection was applied to determine the rate constants by competition kinetics. The rate constant depends both on polymer concentration and on its molecular weight. In dilute solutions, a distinct dependence of the rate constant on the molecular weight is observed. In the studied range of molecular weight, the values of reaction radius, calculated using Smoluchowski equation on the basis of experimental kinetic data, are very close to the radius of gyration of polymer coils. We believe that radius of gyration, as an easily determined parameter, could possibly serve for predicting rate constants of diffusion-controlled reactions of polymers with low-molecular-weight compounds in dilute solutions. With increasing polymer concentration and thus increasing spatial overlap of polymer coils the dependence of the rate constant on the molecular weight fades away, and the rate constant values increase with increasing concentration toward the value determined for low-molecular-weight model of PVP. Most steep increase approximately coincides with the

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Section: Generation Of • Oh Radicalsmentioning

confidence: 99%

Reaction of a low‐molecular‐weight free radical with a flexible polymer chain: Kinetic studies on the OH + poly(N‐vinylpyrrolidone) model

Bartoszek

Ulański

Rosiak

2011

Int J of Chemical Kinetics

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“…Crosslinking of PVP can be performed via chemical reactions, e.g., Fentons reaction relying on the reduction of hydrogen peroxide at the expense of Fe 2+ -ions under formation of hydroxyl radicals initiating vinylic polymerization [17]. Due to the non-necessity of chemical reagents with the advantage of improved biocompatibility, electron beam, or gamma radiation, which similarly lead to hydroxyl radicals from water radiolysis, are more convenient for medical devices [18]. However, by the use of these high-energy radiative processes, degradation of polymeric main chains might compete with successful PVP crosslinking [19].…”

Section: Introductionmentioning

confidence: 99%

Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons

Petersen¹,

Minrath²,

Kaule³

et al. 2013

Coatings

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Polyvinylpyrrolidone (PVP) is a conventionally applied hydrophilic lubricious coating on catheter-based cardiovascular devices, used in order to ease movement through the vasculature. Its use as drug reservoir and transfer agent on drug-coated balloons (DCB) is therefore extremely promising with regard to the simplification of its approval as a medical device. Here, we developed a PVP-based coating for DCB, containing paclitaxel (PTX) as a model drug, and studied the impact of crosslinking via UV radiation on drug stability, wash off, and transfer during simulated use in an in vitro vessel model. We showed that crosslinking was essential for coating stability and needed to be performed prior to PTX incorporation due to decreased drug bioavailability as a result of photodecomposition and/or involvement in vinylic polymerization with PVP under UV radiation. Moreover, the crosslinking time needed to be carefully controlled. While short radiation times did not provide enough coating stability, associated with high wash off rates during DCB insertion, long radiation times lowered drug transfer efficiency upon balloon expansion. A ten minutes radiation of PVP, however, combined a minimized drug wash off rate of 34% with an OPEN ACCESSCoatings 2013, 3 254 efficient drug transfer of 49%, underlining the high potential of photochemically crosslinked PVP as a coating matrix for DCB.

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“…JM. Rosiak and coworkers [8] used gamma irradiation to make hydrogel marketed under the name of AQUA-GEL ®. However, Z. Ajji and coworkers [6] used electron beam with the same composition in order to compare the quality.…”

Section: Introductionmentioning

confidence: 99%

Study of Agar Proportions Effect on a Gamma Ray Synthesized Hydrogel

Ammar¹,

Saied²,

Mejri³

et al. 2016

JMSE-A

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Abstract:In this study, we aimed to identify the effect of agar proportion on the synthesized superabsorbent properties based on PVP (Polyvinyl pyrrolidone), poly (ethylene glycol) (PEG) and agar. In a first stage, the study of swelling and deswelling behavior of synthesized hydrogel was done. It was proved that agar acts as a crosslinking inhibitor since it competes with free radicals. The pH versus swelling time was studied. The polymer was characterized by Fourier transform infrared spectra analysis and X-ray Diffraction. The removal of Cu(II) from aqueous solution by the prepared PVP/PEG/agar hydrogel was studied. Also, the influences of pH and contact time were investigated throughout adsorption experiments. The maximum retention capacity was found to be 36.5 mg g -1 for the hydrogel containing 1% of agar. The kinetic parameters were calculated from the experimental data and it was shown that they fit well with pseudo-second-order kinetic model.

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Fast reaction of irradiated polymers—I. Crosslinking and degradation of polyvinylpyrrolidone

Cited by 22 publications

References 9 publications

Reaction of a low‐molecular‐weight free radical with a flexible polymer chain: Kinetic studies on the OH + poly(N‐vinylpyrrolidone) model

Reaction of a low‐molecular‐weight free radical with a flexible polymer chain: Kinetic studies on the OH + poly(N‐vinylpyrrolidone) model

Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons

Study of Agar Proportions Effect on a Gamma Ray Synthesized Hydrogel

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