Fast quantitation of pyrazole fungicides in wine by ambient ionization mass spectrometry

Pu, Fan; Zhang, Wenpeng; Han, Chao; Ouyang, Zheng

doi:10.1039/c7ay01534h

Cited by 5 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ambient ionization MS techniques have also been extensively used in the fields of food and agricultural analyses, specifically for the detection of food and water contaminants, − food fraud, , and for the discrimination of food products. , PSI, for example, was used by Chen et al to quantify bisphenol A (BPA) and analogues from food packaging . The use of BPA in the production of food packaging has been controversial due to its potential dangers to human health.…”

Section: Applications Of Ambient Ionization Msmentioning

confidence: 99%

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

et al. 2019

View full text Add to dashboard Cite

Section: Applications Of Ambient Ionization Msmentioning

confidence: 99%

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

et al. 2019

View full text Add to dashboard Cite

“…Despite this, conventional PSI has a short spray time (less than 1 min) and less stability, which is not favorable for its practical applications. To prolong the spray time of PSI, diverse strategies (Figure S1), such as covering the paper with a Teflon film, continuously supplying the solvent with a syringe pump, , coupling a 3D-printed cartridge or a Teflon tube , to PSI, embedding a capillary emitter to the tip of a triangle paper substrate, , and inserting a paper strip with dried samples into a nanoESI tube, have been proposed. The analysis time of modified PSI could be extended to more than 20 min, plus high spray stability.…”

Section: Introductionmentioning

confidence: 99%

On-Demand Portable Paper-Based Electrospray Ionization Mass Spectrometry for High-Sensitivity Analysis of Complex Samples

et al. 2023

View full text Add to dashboard Cite

Paper spray ionization has been demonstrated to be the most promising substrate-based source, but this technique suffers from the low desorption efficiency of target compounds and poor portability. In the current study, we describe a portable paper-based electrospray ionization (PPESI) in which a piece of triangle paper and adsorbent are packed sequentially into a modified disposable micropipette tip. This source not only captures the feature of paper spray and adsorbent for highly efficient suppression of sample matrixes for target compound analysis but also takes advantage of a micropipette tip to prevent spray solvent from rapid evaporation. The performance of developed PPESI depends on the type and amount of packed adsorbent, paper substrate, and spray solvent and applied voltage. Moreover, by contrast to other related sources, the analytical sensitivity and the spray duration of PPESI in tandem with MS have been improved by factors of 2.8−32.3 and 2.0−13.3, respectively. Based on its high accuracy (>96%) and precision (less than 3% relative standard deviation), the PPESI coupled to a mass spectrometer has been used to determine diverse therapeutic drugs and pesticides in complex biological (e.g., whole blood, serum, and urine) and food (e.g., milk and orange juice) matrixes, and the limits of detection and quantification were 2−4 pg mL −1 and 7−13 pg mL −1 , respectively. Taking the portability, high sensitivity, and repeatability, the technique may be a promising alternative for complex sample analysis.

show abstract

“…This approach uses small amounts of solvent and can be performed in as little as one minute. Several applications have been published utilizing this technique, including analysis of pesticides [22, 23], fungicides [24, 25], illicit drugs [26, 27], bacterial identification [28], and direct aerosol capture and identification [29]. Modification of the paper surface with compounds such as carbon nanotubes [30], metal-organic frameworks (MOFs) [31, 32], and silanes [33] has also been utilized to target specific applications.…”

Section: Introductionmentioning

confidence: 99%

On-substrate Enzymatic Reaction to Determine Acetylcholinesterase Activity in Whole Blood by Paper Spray Mass Spectrometry

Carmany

Mach²,

Rizzo

et al. 2018

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Currently, all assays measuring acetylcholinesterase (AChE) activity following a suspected nerve agent exposure leverage methodologies that fail to identify the agent. This limits the overall effectiveness and ability to administer proper countermeasures. As such, there is an urgent need to identify novel, rapid, and more comprehensive approaches to establish AChE activity, including identification of the toxicant. Paper spray mass spectrometry was used to monitor the activity of acetylcholinesterase, both in-solution and on modified hydrophobic paper surface. Hydrophobic paper surfaces were prepared using vaporized trichloro(3,3,3-trifluoropropyl)silane. In both approaches, mixtures of diluted human whole blood with and without VX were mixed with a non-endogenous AChE specific substrate, 1,1-dimethyl-4-acetylthiomethylpiperidinium (MATP+). Formation of the cleaved MATP+ product was monitored over time and compared to MATP+ to determine relative AChE activity. This on-substrate assay was effective at determining AChE activity and identifying the toxicant; however, determination of AChE activity in-solution proceeded at a slower rate. The on-substrate assay serves as a pioneering example of an enzymatic reaction occurring on the surface of a paper spray ionization ticket. This work broadens the range of applications relating to paper spray ionization-based clinical diagnostic assays. Graphical Abstractᅟ Electronic supplementary materialThe online version of this article (10.1007/s13361-018-2072-1) contains supplementary material, which is available to authorized users.

show abstract

Fast quantitation of pyrazole fungicides in wine by ambient ionization mass spectrometry

Cited by 5 publications

References 41 publications

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

Ambient Ionization Mass Spectrometry: Recent Developments and Applications

On-Demand Portable Paper-Based Electrospray Ionization Mass Spectrometry for High-Sensitivity Analysis of Complex Samples

On-substrate Enzymatic Reaction to Determine Acetylcholinesterase Activity in Whole Blood by Paper Spray Mass Spectrometry

Contact Info

Product

Resources

About