Fast processes of nanoparticle blood clearance: Comprehensive study

Zelepukin, Ivan V.; Yaremenko, A. V.; Yuryev, Mikhail; Mirkasymov, Aziz B.; Sokolov, I. L.; Deyev, Sergey M.; Никитин, П. И.; Nikitin, Maxim P.

doi:10.1016/j.jconrel.2020.07.014

Cited by 55 publications

(68 citation statements)

References 64 publications

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“…is a critical task for the successful application of in vivo magnetofection. In this sense, our laboratory has achieved a certain success: in addition to a comprehensive study of various factors affecting the circulation time of nanoagents in the bloodstream [ 146 ], we were able to increase the circulation half-life of a range of short-circulating and long-circulating nanoparticle formulations by up to 32-fold via a new “MPS-cytoblockade” technology (via partial blocking of the mononuclear phagocyte system with self-erythrocytes sensitized with administered anti-RBC antibodies) [ 3 ]. We also studied carefully the effect of different factors on the efficiency of a macrophage blockade in vivo induced by solid nanomaterials [ 147 ], and we demonstrated that RBC-hitchhiking can boost the delivery of nontargeted particles to the lungs up to the record of 120-fold [ 148 ].…”

Section: Discussionmentioning

confidence: 99%

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

et al. 2021

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Magnetic nanoparticles have been widely used in nanobiomedicine for diagnostics and the treatment of diseases, and as carriers for various drugs. The unique magnetic properties of “magnetic” drugs allow their delivery in a targeted tumor or tissue upon application of a magnetic field. The approach of combining magnetic drug targeting and gene delivery is called magnetofection, and it is very promising. This method is simple and efficient for the delivery of genetic material to cells using magnetic nanoparticles controlled by an external magnetic field. However, magnetofection in vivo has been studied insufficiently both for local and systemic routes of magnetic vector injection, and the relevant data available in the literature are often merely descriptive and contradictory. In this review, we collected and systematized the data on the efficiency of the local injections of magnetic nanoparticles that carry genetic information upon application of external magnetic fields. We also investigated the efficiency of magnetofection in vivo, depending on the structure and coverage of magnetic vectors. The perspectives of the development of the method were also considered.

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Section: Discussionmentioning

confidence: 99%

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

et al. 2021

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“…An important characteristic feature of this approach is its versatility: i.e., independence of the nature, size, and other properties of the nanoparticles [ 212 ]. Ideologically close to this approach is the method in which “inert” nanoagents are first introduced into the body, triggering an attack by the immune system, and only after that are drug-loaded nanoparticles introduced [ 213 ]. Thus, it can be concluded that studies of the practical application of theranostic PL drugs should focus on a combination of highly effective, targeted nanoagents capable of detecting a pathogenic centre with high accuracy [ 214 ] and technologies that ensure their sufficiently long circulation time in the bloodstream.…”

Section: Discussionmentioning

confidence: 99%

Photoluminescent Nanomaterials for Medical Biotechnology

et al. 2021

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Creation of various photoluminescent nanomaterials has significantly expanded the arsenal of approaches used in modern biomedicine. Their unique photophysical properties can significantly improve the sensitivity and specificity of diagnostic methods, increase therapy effectiveness, and make a theranostic approach to treatment possible through the application of nanoparticle conjugates with functional macromolecules. The most widely used nanomaterials to date are semiconductor quantum dots; gold nanoclusters; carbon dots; nanodiamonds; semiconductor porous silicon; and up-conversion nanoparticles. This paper considers the promising groups of photoluminescent nanomaterials that can be used in medical biotechnology: in particular, for devising agents for optical diagnostic methods, sensorics, and various types of therapy.

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“…with cells. [36][37][38][39] Data presented in Figure 8 were obtained using Amnis ImageStream X Mark II imaging flow cytometer. ImageStream, unlike conventional cytometers, employs in its optical systems a time-delay integration-CCD camera, 40 which takes photos of objects in the flow instead of detection of scattered light.…”

Section: Impact Of Rc Mps On Tumor Cells In Culturementioning

confidence: 99%

Radachlorin-Containing Microparticles for Photodynamic Therapy

et al. 2020

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Purpose: Reducing the undesirable systemic effect of photodynamic therapy (PDT) can be achieved by incorporating a photosensitizer in microparticles (MPs). This study is devoted to the preparation of biocompatible biodegradable MPs with the inclusion of the natural photosensitizer Radachlorin (RС) and an assessment of the possibility of their use for PDT. Methods: RC-containing MPs (RС MPs) with poly(lactic-co-glycolic acid) copolymer (PLGA) matrix were prepared by a double emulsion solvent evaporation methods. The size and morphology of RC MPs were surveyed using scanning electron microscopy, confocal laser scanning microscopy, and dynamic light scattering. The content of RC, its release from RC MPs, and singlet oxygen generation were evaluated by the optical spectroscopy. Cellular uptake and cytotoxic photodynamic effect of RC MPs were investigated with in vitro assays. Results: The average diameter of the prepared RC MPs was about 2-3 μm. The RC MPsprepared by the water/oil/oil method had a significantly higher inclusion of RC (1.74 μg/mg) then RC MPs prepared by the water/oil/water method (0.089 μg/mg). Exposure of the prepared RC MPs to PDT light radiation was accompanied by the singlet oxygen generation and a cytotoxic effect for tumor cells. The release of the RC from the RC MPs was prolonged and lasted at least two weeks. Conclusion: PLGA RC MPs were found to cause a photoactivated cytotoxic effect for tumor cells and can be used for local application in PDT of tumors.

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Fast processes of nanoparticle blood clearance: Comprehensive study

Cited by 55 publications

References 64 publications

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

Photoluminescent Nanomaterials for Medical Biotechnology

Radachlorin-Containing Microparticles for Photodynamic Therapy

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