Fast neutron treatment for squamous cell carcinoma of the head and neck: final report of Edinburgh randomised trial.

MacDougall, R.H.; Orr, J.A.; Kerr, G.R.; Duncan, W.

doi:10.1136/bmj.301.6763.1241

Cited by 30 publications

(11 citation statements)

References 4 publications

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“…For most normal tissue side effects, the RBE of neutron beams used in therapy is in the range Particle radiotherapy for head and neck cancer Laramore 225 There was considerable early interest in using fast neutrons to treat locally advanced HNSCC, and early reports from Catterall et al [4,5] at Hammersmith Hospital were quite favorable. Subsequent reports from other European centers did not confirm the therapeutic efficacy and, moreover, showed considerable treatment-related morbidity [6,7]. In the United States, the Radiation Therapy Oncology Group (RTOG) conducted two multiinstitutional, randomized trials for HNSCC.…”

Section: Neutron Radiotherapymentioning

confidence: 98%

Role of particle radiotherapy in the management of head and neck cancer

Laramore

2009

Current Opinion in Oncology

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Fast-neutron radiotherapy has different radiobiological properties compared with standard radiotherapy but similar depth dose distributions. Its role in the treatment of head and neck cancer is currently limited to salivary gland malignancies and certain radioresistant tumors such as sarcomas. Protons have the same radiobiological properties as standard radiotherapy beams but more optimal depth dose distributions, making it particularly advantageous when treating tumors adjacent to highly critical structures. Heavy ions combine the radiobiological properties of fast neutrons with the physical dose distributions of protons, and preliminary data indicate their utility for radioresistant tumors adjacent to highly critical structures.

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Section: Neutron Radiotherapymentioning

confidence: 98%

Role of particle radiotherapy in the management of head and neck cancer

Laramore

2009

Current Opinion in Oncology

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“…However, the late effects were somewhat alarming, with late grade 3 to 5 toxicities of up to 40%. 33 The RTOG and Medical Research Council (MRC) conducted a trial for salivary gland tumors comparing fast neutron versus photon therapy. The trial included 25 patients with locally advanced disease.…”

Section: Particle Therapiesmentioning

confidence: 99%

Head and Neck Cancers, Version 1.2015

Pfister

Spencer

Brizel

et al. 2015

J Natl Compr Canc Netw

199

246

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These NCCN Guidelines Insights focus on recent updates to the 2015 NCCN Guidelines for Head and Neck (H&N) Cancers. These Insights describe the different types of particle therapy that may be used to treat H&N cancers, in contrast to traditional radiation therapy (RT) with photons (x-ray). Research is ongoing regarding the different types of particle therapy, including protons and carbon ions, with the goals of reducing the long-term side effects from RT and improving the therapeutic index. For the 2015 update, the NCCN H&N Cancers Panel agreed to delete recommendations for neutron therapy for salivary gland cancers, because of its limited availability, which has decreased over the past 2 decades; the small number of patients in the United States who currently receive this treatment; and concerns that the toxicity of neutron therapy may offset potential disease control advantages.

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“…The UK has a strong track record in practice-changing radiotherapy clinical trials [6][7][8][9][10][11][12][13]. Several of these have provided proof of principle of the value of technical innovation.…”

Section: Meeting Discussion Themesmentioning

confidence: 99%