Fast myocardial perfusion imaging with 99mTc in challenging patients using conventional SPECT cameras

Katsikis, Athanasios; Theodorakos, Athanasios; Kouzoumi, A.; Kitziri, Elpida; Georgiou, Evangelos; Koutelou, Maria

doi:10.1007/s12350-016-0431-5

Cited by 5 publications

(6 citation statements)

References 22 publications

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“…In another study of 78 patients that were imaged with tetrofosmin early and late (15 and 45 minutes) after stress and rest injection, the anterior raw images were used to create regions of interest over the heart, lungs, liver, and subdiaphragmatic area. 19 The stress and rest counts in the heart, liver, lungs, and subdiaphragmatic areas were all greater at 15 minutes. However, there was no significant difference in any of the stress heart-to-anything ratios.…”

Section: Resultsmentioning

confidence: 90%

“…Finally, Katsikis et al performed essentially the same study using a one-day stress-rest protocol with exercise or adenosine stress with 78 patients who were imaged with tetrofosmin early and late (15 and 45 minutes) following stress and rest tracer injection. 19 Image quality was assessed using a four-point scale, and 93% of the early imaging group had optimal or good image quality compared to 98% of the late imaging group. There was no significant difference in the calculated LVEF between groups.…”

Section: Resultsmentioning

confidence: 99%

“…

Figure 7 Comparison of heart-to-liver,-lung, and -subdiaphragmatic area activity ratios between early and late tetrofosmin imaging in 78 patients. 19 Statistically significant P values are noted …”

Section: Resultsmentioning

confidence: 99%

“…Comparison of heart-to-liver,-lung, and -subdiaphragmatic area activity ratios between early and late tetrofosmin imaging in 78 patients. 19 Statistically significant P values are noted. The size of the diamonds is proportional to the number of patients analyzed in each study was found to be 27% shorter with tetrofosmin, which was a statistically and clinically significant 34 minutes shorter.…”

Section: At Rest At Stress Cardiac To Extra-cardiac Activity Ratiosmentioning

confidence: 99%

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Efficiency of tetrofosmin versus sestamibi achieved through shorter injection-to-imaging times: A systematic review of the literature

Duvall

Case

Lundbye

et al. 2021

Journal of Nuclear Cardiology

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Based on superior image quality, more accurate gated images, and lower radiation exposure to patients, Technetium-99m (Tc-99m) based tracers are preferred over Thallium-201 for SPECT myocardial perfusion imaging. The two Tc-99m tracers, sestamibi and tetrofosmin, have many similar characteristics but there are differences in blood and liver clearance rates, as well as the recommended time after injection for imaging to achieve optimal image quality. Because published peer-reviewed studies examining optimal times between injection and imaging are limited, it can be difficult to identify evidence-based opportunities to optimize imaging protocols. Using systematic literature review methods, this study was designed to identify and consolidate the available evidence on the use of sestamibi compared to tetrofosmin for variable injection to imaging times in regard to test efficiency, including test length and re-scan rates, and image quality, including overall quality and cardiac to extra-cardiac ratios. The composite of this data shows that earlier imaging with tetrofosmin is equivalent to later imaging with sestamibi when assessing subjective image quality or when quantifying heart-to-extra-cardiac ratios. Image quality and heart-to-extra-cardiac ratios comparing early versus later imaging with tetrofosmin were comparable if not equivalent to each other. The equivalency of the imaging quality occurs with 15 minutes (on average) earlier imaging compared to sestamibi and 30 minutes compared to standard time tetrofosmin. The subjective findings of equivalent image quality are also shown with objective measurements of heart-to-extra-cardiac ratios. In this review, the significantly shorter injection-to-acquisition times with tetrofosmin compared to sestamibi resulted in better efficiency and less waiting times for patients; in addition, significantly higher re-scan rates with sestamibi compared to tetrofosmin due to hepatic activity contributed to better throughput with tetrofosmin. (J Nucl Cardiol 2020)

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

“…

Section: Resultsmentioning

confidence: 99%

Section: At Rest At Stress Cardiac To Extra-cardiac Activity Ratiosmentioning

confidence: 99%

See 2 more Smart Citations

Efficiency of tetrofosmin versus sestamibi achieved through shorter injection-to-imaging times: A systematic review of the literature

Duvall

Case

Lundbye

et al. 2021

Journal of Nuclear Cardiology

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“…In this current issue of the Journal, Katsikis et al 15 report the results of a prospective study comparing early (15 minutes post i.v) and late (45 minutes post i.v) MPI with 99mTc-tetrofosmin. They evaluated the feasibility and diagnostic accuracy of a fast imaging protocol with both exercise and pharmacologic vasodilation in a diagnostically challenging patient population.…”

mentioning

confidence: 99%

Myocardial perfusion imaging with 99mTc-labeled radiopharmaceuticals: How fast can a stress-rest same-day imaging protocol be completed?

Taillefer

2017

Journal of Nuclear Cardiology

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Review of cardiovascular imaging in the Journal of Nuclear Cardiology in 2017. Part 2 of 2: Myocardial perfusion imaging

Hage

AlJaroudi

2018

Journal of Nuclear Cardiology

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In 2017, the Journal of Nuclear Cardiology published many high-quality articles. In this review, we will summarize a selection of these articles to provide a concise review of the main advancements that have recently occurred in the field. In the first article of this 2-part series, we focused on publications dealing with positron emission tomography, computed tomography, and magnetic resonance. This review will place emphasis on myocardial perfusion imaging using single-photon emission computed tomography summarizing advances in the field including prognosis, safety and tolerability, the impact of imaging on management, and the use of novel imaging protocols.

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Fast myocardial perfusion imaging with 99mTc in challenging patients using conventional SPECT cameras

Abstract: The fast protocol is technically feasible and diagnostically accurate compared to the established protocol in diagnostically challenging patients.

Cited by 5 publications

References 22 publications

Efficiency of tetrofosmin versus sestamibi achieved through shorter injection-to-imaging times: A systematic review of the literature

Efficiency of tetrofosmin versus sestamibi achieved through shorter injection-to-imaging times: A systematic review of the literature

Myocardial perfusion imaging with 99mTc-labeled radiopharmaceuticals: How fast can a stress-rest same-day imaging protocol be completed?

Review of cardiovascular imaging in the Journal of Nuclear Cardiology in 2017. Part 2 of 2: Myocardial perfusion imaging

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