Fast mixing by lamination

Branebjerg, Jens; Gravesen, Peter; Krog, J.P.; Nielsen, Claus Rye

doi:10.1109/memsys.1996.494022

Cited by 149 publications

(130 citation statements)

References 5 publications

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“…The basic approach is to split the flow of two fluid layers perpendicularly to the interface, introduce into two separate channels, and then reunite them downstream. Theoretically, if the flow is laminar, after passing n mixers in series, two fluids will be laminated in 2 n layers and mixing becomes 4 n−1 times faster (18) . Whereas an exponential decrease of lamellae thickness is obtained, the increase in total pressure drop ∆p is linear.…”

Section: Mixer Designmentioning

confidence: 99%

See 1 more Smart Citation

A Lamination Micro Mixer for .MU.-Immunomagnetic Cell Sorter

Tan

Suzuki

Kasagi

et al. 2005

JSME Int. J., Ser. C

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We report successful design, fabrication and testing of a novel lamination micro mixer to be integrated in the micro-scale immunomagnetic cell sorter (µ-IMCS), which should be a key device for clinical applications of regenerative medicine. This paper covers, (i) the concept of µ-IMCS, (ii) design and fabrication of lamination mixer using MEMS technologies, (iii) numerical analysis for the evaluation of the mixer performance, and (iv) experimental evaluation of target cell capturing with the present micro mixer. In order to reduce the sedimentation loss of the cells and the magnetic beads, the conduits in the mixer are designed in such a way that the stream is turned over 180 degree. It is found in the CFD analysis that the present lamination mixer realizes better mixing and lower sedimentation loss than the one without rotation in the previous study. Experiments reveal that the cell capture rate is (i) increased by up to 8.6 times compared with that in a straight channel, and (ii) decreased with decreasing the residence time. It is also demonstrated in a preliminary experiment that CD31 expressions of HUVEC and hMSC obtained with the present micro mixer are in good agreement with the data obtained with a conventional cell sorting system. Therefore, the present mixer should be a viable component in a µ-IMCS.

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Section: Mixer Designmentioning

confidence: 99%

“…Mixing principles such as chaotic advection (15), (16) , hydrodynamic focusing (17) and lamination (18) - (20) have been re-ported. Unlike active mixers, fabrication process is relatively simple, and complete mixing is possible for different flow rate with a single channel geometry.…”

Section: Introductionmentioning

confidence: 99%

A Lamination Micro Mixer for .MU.-Immunomagnetic Cell Sorter

Tan

Suzuki

Kasagi

et al. 2005

JSME Int. J., Ser. C

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“…This can be achieved with systems based on multi-lamination mechanism and baker's transformation [11,12]. These have been proposed especially in the context of microfluidics [13][14][15][16]. In microfluidic devices, the typical channel dimensions and flow rates are so low that all flow is laminar (Re % 0.1) and turbulence cannot be achieved.…”

Section: Introductionmentioning

confidence: 99%

Implementation of ‘chaotic’ advection for viscous fluids in heat exchanger/reactors

Anxionnaz‐Minvielle

Tochon

Couturier

et al. 2017

Chemical Engineering and Processing: Process Intensification

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. This is an author-deposited version published in : http://oatao.univ-toulouse.fr/ Eprints ID : 17719 A B S T R A C TWhen viscous fluids are involved, laminar hydraulic conditions and heat and mass transfer intensification are conflicting phenomena. A channel geometry based on Split-And-Recombine (SAR) patterns is experimentally investigated. The principle implements the Baker's transformation and 'chaotic' structures are generated to promote heat and mass transfer. This work assesses the energy efficiency of different heat exchanger/reactors integrating these SAR patterns.The heat transfer capacity is assessed and compared with the energy consumption of each mock-up. It is sensitive to the cooling mode and to the number of SAR patterns per length unit as well.The continuous oxidation of sodium thiosulfate with hydrogen peroxide has been implemented. Conversions up to 99% are reached according to the utility fluid temperature and the residence time.Finally, the whole performances of the SAR geometries are compared to a plate-type heat exchanger/ reactor with a corrugated pattern. The more viscous the fluid, the more the energy efficiency of the SAR design increases compared to the corrugated design because of the balance between advection and diffusion mechanisms. The interest in terms of energy efficiency in working with SAR heat exchanger/ reactor appears from Reynolds numbers below 50.

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“…On the other hand, the passive micromixers use the geometrical structure of the conduit, so that the stretching and folding of fluids are induced by the chaotic advection (5,6) or the lamination of interfaces. (7)(8)(9)(10) The mixers using the latter mechanism, which are called lamination mixers or split-and-recombine (SAR) mixers, can simplify the fabricating and operating processes as compared to the active mixers. In order to optimize the design of micro mixing devices, the flow characteristics and the resulting mixing performance should be investigated in detail.…”

Section: Introductionmentioning

confidence: 99%

Performance Assessment and Improvement of a Spilt-and-Recombine Micromixer for Immunomagnetic Cell Sorting

Chaktranond

Fukagata²,

Kasagi

2008

JFST

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Performance of a split-and-recombine micromixer (Tan et al., 2005) is assessed by means of numerical simulation. The micromixer is designed for micro cell sorting systems using immunomagnetic beads, of which working principle is lamination of fluid layers. The fluid motion in a complex three-dimensional geometry is simulated by using the finite difference method and the motion of beads is dealt with the one-way coupling Lagrangian particle tracking method. Although the thickness of laminated layers should ideally reduce by the factor of 2 n (where n is the number of unit-mixers connected in series), the present simulation with a realistic geometry shows that the thickness does not reduce that much. Relatively large unmixed regions are formed in the central region, which deteriorate the mixing performance. The size of the unmixed regions and the degree of mixing are quantitatively investigated. Based on the observation, an improved mixer arrangement is proposed. While the original arrangement proposed by Tan et al. (2005) was to simply connect identical unit-mixers, the present arrangement is to alternately connect the original unit-mixer and one with the mirrored geometry. With this modified arrangement, the unmixed region is suppressed and better mixing is achieved.

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Fast mixing by lamination

Cited by 149 publications

References 5 publications

A Lamination Micro Mixer for .MU.-Immunomagnetic Cell Sorter

A Lamination Micro Mixer for .MU.-Immunomagnetic Cell Sorter

Implementation of ‘chaotic’ advection for viscous fluids in heat exchanger/reactors

Performance Assessment and Improvement of a Spilt-and-Recombine Micromixer for Immunomagnetic Cell Sorting

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