Fast magnetic resonance fingerprinting for dynamic contrast‐enhanced studies in mice

Gu, Yuning; Wang, Charlie Y.; Anderson, Christian E.; Liu, Yu-Chi; Hu, He; Johansen, Mette L.; Ma, Dan; Jiang, Yun; Ramos-Estébanez, Ciro; Brady‐Kalnay, Susann M.; Griswold, Mark A.; Flask, Chris A.; Yu, Xin

doi:10.1002/mrm.27345

Cited by 20 publications

(22 citation statements)

References 33 publications

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“…In this work, MRF signal was acquired with traditional k‐space sampling. While more k‐space samplings after signal excitation can further reduce the scanning time, TR would be longer for the lengthened k‐space sampling window . The transient steady‐state free precession (SSFP) signal in MRF is sensitive to MT effect, especially with short TR, and MRF signal is usually acquired with TR as short as possible for significant acquisition time reduction .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the effect of magnetization‐preparation in MRF was analyzed. In previous relaxation measurements with MRF, an inversion pulse was usually applied before a train of fast imaging with variable FAs and TR delays . With inversion‐recovery (IR) preparation, the recovery signal is susceptible to MT and the measured T 1 depends on the inversion time, while the saturation‐recovery (SR)‐prepared acquisition produces more accurate measurements than the IR‐prepared repetitive acquisition .…”

Section: Introductionmentioning

confidence: 99%

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Improved MR fingerprinting for relaxation measurement in the presence of semisolid magnetization transfer

Meng

Cheung

Sun

2020

Magnetic Resonance in Med

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Purpose: To characterize and minimize the magnetization transfer (MT) effect in MR fingerprinting (MRF) relaxation measurements with a 2-pool (2P) MT model of multiple tissue types. Theory and Methods: Semisolid MT effect in MRF was modeled using 2P Bloch-McConnell equations. The combinations of MT parameters of multiple tissues (white [WM] and gray matter [GM]) were used to build the MRF dictionary. Both 1-pool (1P) and 2P models were simulated to characterize the dependence on MT. Relaxations measured using MRF with spin-echo saturation-recovery (SR) or inversion-recovery preparations were compared with conventional SR-prepared T 1 and multiple spinecho T 2 measurements. The simulations results were validated with phantoms and brain tissue samples. Results: The MRF signal was different from the 1P and 2P models. 1P MRF produced significantly (P < .05) underestimated T 1 in WM (20-30%) and GM (7-10%), while 2P MRF measured consistent T 1 and T 2 in both WM and GM with conventional measurements (pairwise test P > .1; correlated P < .05). Simulations showed that SRprepared MRF measuring T 1 had much less errors against the variation of the macromolecular fraction. Compared with inversion-recovery preparation, SR-prepared MRF produced higher relaxation correlations (R > 0.9) with conventional measurements in both WM and GM across samples, suggesting that SR-prepared MRF was less sensitive to the compositive effect of multiple MT parameters variations. Conclusions: 2P MRF using a combination of MT parameters for multiple tissue types can measure consistent relaxations with conventional methods. With the 2P models, SR-prepared MRF would provide an option for robust relaxation measurement under heterogeneous MT. K E Y W O R D S MRF, MT, saturation-recovery 728 | MENG Et al.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improved MR fingerprinting for relaxation measurement in the presence of semisolid magnetization transfer

Meng

Cheung

Sun

2020

Magnetic Resonance in Med

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“…MRF can acquire quantitative maps with sufficiently high spatial and temporal resolution to use advanced kinetic models that better characterize tissue. Gu et al assessed DCE‐based MRF (both SSFP and bSSFP implementations) at 7T. The phantom was used to validate data undersampling up to a factor of eight without loss of accuracy, which enabled 2‐minute temporal resolution in mouse brains.…”

Section: Technique Development For Clinical Applicationsmentioning

confidence: 99%

Magnetic resonance fingerprinting Part 1: Potential uses, current challenges, and recommendations

Poorman

Martin

et al. 2019

Magnetic Resonance Imaging

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Magnetic resonance fingerprinting (MRF) is a powerful quantitative MRI technique capable of acquiring multiple property maps simultaneously in a short timeframe. The MRF framework has been adapted to a wide variety of clinical applications, but faces challenges in technical development, and to date has only demonstrated repeatability and reproducibility in small studies. In this review, we discuss the current implementations of MRF and their use in a clinical setting. Based on this analysis, we highlight areas of need that must be addressed before MRF can be fully adopted into the clinic and make recommendations to the MRF community on standardization and validation strategies of MRF techniques. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:675–692.

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“…For this initial in vivo study, the DC-MRF methodology was used to simultaneously detect a gadolinium chelate (Gd-BOPTA) and a dysprosium chelate (Dy-DOTA-azide) in a mouse glioma model. These two contrast agents were selected on the basis of the following rationale: (1) both agents have been previously studied in animal models 15,16 ; (2) both agents have similar molecular weights and should therefore be expected to have similar tumor pharmacokinetics 15 ; and (3) these two contrast agents have different magnetic relaxivity ratios (r 2 /r 1 , Supplementary Fig. 1) enabling the multi-agent relaxation model (Eqs.…”

Section: Resultsmentioning

confidence: 99%

“…2a and 2b to be solved analytically. Further, the advantage of the MRF acquisition itself is that it has already been shown to provide simultaneous and repeatable measurements of T 1 and T 2 relaxation time constants in non-contrast studies on both animal 15,25–27 and human MRI scanners 28–31 spanning a wide range of field strengths with improved precision and temporal efficiency in comparison to conventional quantitative MRI techniques. MRF has also shown the ability to measure numerous MRI tissue properties beyond T 1 and T 2 32–36 .…”

Section: Discussionmentioning

confidence: 99%

Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast - Magnetic Resonance Fingerprinting

Anderson

Johansen

Erokwu

et al. 2019

Sci Rep

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Synchronous assessment of multiple MRI contrast agents in a single scanning session would provide a new “multi-color” imaging capability similar to fluorescence imaging but with high spatiotemporal resolution and unlimited imaging depth. This multi-agent MRI technology would enable a whole new class of basic science and clinical MRI experiments that simultaneously explore multiple physiologic/molecular events in vivo. Unfortunately, conventional MRI acquisition techniques are only capable of detecting and quantifying one paramagnetic MRI contrast agent at a time. Herein, the Dual Contrast – Magnetic Resonance Fingerprinting (DC-MRF) methodology was extended for in vivo application and evaluated by simultaneously and dynamically mapping the intra-tumoral concentration of two MRI contrast agents (Gd-BOPTA and Dy-DOTA-azide) in a mouse glioma model. Co-registered gadolinium and dysprosium concentration maps were generated with sub-millimeter spatial resolution and acquired dynamically with just over 2-minute temporal resolution. Mean tumor Gd and Dy concentration measurements from both single agent and dual agent DC-MRF studies demonstrated significant correlations with ex vivo mass spectrometry elemental analyses. This initial in vivo study demonstrates the potential for DC-MRF to provide a useful dual-agent MRI platform.

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Fast magnetic resonance fingerprinting for dynamic contrast‐enhanced studies in mice

Abstract: Magnetic resonance fingerprinting provides the opportunity for dynamic quantification of contrast agent distribution in preclinical tumor models on high-field MRI scanners.

Cited by 20 publications

References 33 publications

Improved MR fingerprinting for relaxation measurement in the presence of semisolid magnetization transfer

Improved MR fingerprinting for relaxation measurement in the presence of semisolid magnetization transfer

Magnetic resonance fingerprinting Part 1: Potential uses, current challenges, and recommendations

Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast - Magnetic Resonance Fingerprinting

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