Fast living cationic polymerization of isobutyl vinyl ether tailored by single nucleophile in microflow system

Xie, Dan; Lu, Yangcheng

doi:10.1016/j.eurpolymj.2019.01.046

Cited by 9 publications

(1 citation statement)

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“…Significant emphasis has been placed on designing "universal" polymerization routes, with the aim being to effect excellent control over the chain-growth kinetics with narrow molecular weight distributions by altering the catalyst concentration or temporal regulation of initiation. 142 For instance, using a microflow system, Xie et al 152 have attempted to control the molecular weight and dispersity of isobutyl vinyl ether (IBVE) polymers produced from a living cationic polymerization by simplifying the construction of the initiation system, involving real-time combination of initiators, co-initiators, and nucleophiles. Their microflow system consists of two T-shaped micromixers for the mixing of monomer solution and co-initiator solution (Lewis acid) and an inlet for the injection of the termination agent (methanol containing a small amount of aqueous ammonia solution (0.1 vol %)), allowing a controlled polymerization process with t 1/2 (time to reach 50% conversion) as short as 0.22 s (which could be tailored by changing the flow rate or the length of reaction tubes).…”

Section: Reactions In Flow: Continuous Flow Polymerizationmentioning

confidence: 99%

High-Throughput Routes to Biomaterials Discovery

2021

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Many existing clinical treatments are limited in their ability to completely restore decreased or lost tissue and organ function, an unenviable situation only further exacerbated by a globally aging population. As a result, the demand for new medical interventions has increased substantially over the past 20 years, with the burgeoning fields of gene therapy, tissue engineering, and regenerative medicine showing promise to offer solutions for full repair or replacement of damaged or aging tissues. Success in these fields, however, inherently relies on biomaterials that are engendered with the ability to provide the necessary biological cues mimicking native extracellular matrixes that support cell fate. Accelerating the development of such “directive” biomaterials requires a shift in current design practices toward those that enable rapid synthesis and characterization of polymeric materials and the coupling of these processes with techniques that enable similarly rapid quantification and optimization of the interactions between these new material systems and target cells and tissues. This manuscript reviews recent advances in combinatorial and high-throughput (HT) technologies applied to polymeric biomaterial synthesis, fabrication, and chemical, physical, and biological screening with targeted end-point applications in the fields of gene therapy, tissue engineering, and regenerative medicine. Limitations of, and future opportunities for, the further application of these research tools and methodologies are also discussed.

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Section: Reactions In Flow: Continuous Flow Polymerizationmentioning

confidence: 99%