Fast label-free detection of C-reactive protein using broad-band Mach-Zehnder interferometers integrated on silicon chips

Psarouli, A.; Botsialas, A.; Salapatas, Alexandros; Stefanitsis, Gerasimos; Nikita, Dimitra; Jobst, G.; Chaniotakis, Nikos A.; Goustouridis, D.; Makarona, Eleni; Petrou, Panagiota; Raptis, Ioannis; Μισιακός, Κωνσταντίνος; Kakabakos, Sotirios

doi:10.1016/j.talanta.2017.01.001

Cited by 25 publications

(16 citation statements)

References 53 publications

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“…The device was also applied for the detection of mycotoxin ochratoxin A in beer samples with a detection limit of 2.0 ng/mL and a dynamic range of 4.0-100 ng/mL, demonstrating the potential for applications of the device in food analysis [135]. Another single analyte application concerned the determination of CRP, a widely used inflammation marker, in human serum samples with an LOD of 2.1 ng/mL and a quantification limit of 4.2 ng/mL [136]. The CRP concentrations determined in human serum samples were in agreement with those determined for the same samples by a standard clinical laboratory method run in a clinical analyser, further supporting the accuracy of the measurements performed with the developed device.…”

Section: Monolithically Integrated Broad-band Optoelectronic Transducersmentioning

confidence: 99%

Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers

2018

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The article reviews the current status of label-free integrated optical biosensors focusing on the evolution over the years of their analytical performance. At first, a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical biosensors, including sensors based on surface plasmon resonance (SPR), grating couplers, photonic crystals, ring resonators, and interferometric transducers. For each type of biosensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free optical biosensors is provided.

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Section: Monolithically Integrated Broad-band Optoelectronic Transducersmentioning

confidence: 99%

Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers

2018

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Section: Silicon‐based Label‐free Optical Biosensorsmentioning

confidence: 99%

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare.

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“…Moreover, the light coupled to the device was just a little fraction of the incident light [116]. The only reliable solution provided so far to this problem was the implementation as light sources of silicon light emitting diodes (LED) integrated onto the same silicon chip with planar silicon nitride waveguides [117,[119][120][121][122][123][124][125][126][127][128][129][130][131]. The LEDs were silicon avalanche diodes that emitted polychromatic light covering all the visible and near IR spectrum when biased beyond their breakdown point [118].…”

Section: Monolithically Integrated Broad-band Optoelectronic Transducersmentioning

confidence: 99%

“…The device was also applied for the detection of mycotoxin ochratoxin A in beer samples with a detection limit of 2.0 ng/ml and a dynamic range 4.0-100 ng/mL, demonstrating the potential for application of the device in food analysis [128]. Another single analyte application concerned the determination of C-reactive protein (CRP), a widely used inflammation marker, in human serum samples with a LOD of 2.1 ng/mL and a quantification limit of 4.2 ng/mL [129]. The CRP concentrations determined in human serum samples were in agreement with those determined for the same samples by a standard clinical laboratory method run in a clinical analyser, further supporting the accuracy of the measurements performed with the developed device.…”

Section: Monolithically Integrated Broad-band Optoelectronic Transducersmentioning

confidence: 99%

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

Angelopoulou¹,

Kakabakos²,

Petrou³

2018

Preprint

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The article reviews the current status of label-free integrated optical sensors focusing on the evolution over the years of their analytical performance. At first a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical sensors including sensors based on surface plasmon resonance (SPR), grating coupler, photonic crystals, ring resonators and interferometric transducers. After a short reference to SPR techniques, including localized SPR, integrated optical sensors i.e., grating-couplers, interferometers, photonic crystals, microring resonators are reviewed. For each type of sensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free biosensors optical sensors is provided

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Fast label-free detection of C-reactive protein using broad-band Mach-Zehnder interferometers integrated on silicon chips

Cited by 25 publications

References 53 publications

Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers

Label-Free Biosensors Based onto Monolithically Integrated onto Silicon Optical Transducers

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Label-Free Biosensors Based Onto Monolithically Integrated Onto Silicon Optical Transducers

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