Fast inversion recovery for myelin suppression (FIRMS) a new MRI pulse sequence for highlighting cerebral gray matter

Wolansky, Leo; Evans, A; Belitsis, Kenneth; Shaderowfsky, Paul D.; Gonzales, Reynaldo N.; Maldjian, Joseph A.; Lee, Huey Jen; Pak, Jayoung

doi:10.1016/0899-7071(96)00015-0

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…Inversion recovery sequences with short inversion times providing more T2W (STIR) and medium inversion times providing more T1W (T1 FLAIR) are useful for increasing the contrast between the cerebral cortex and subcortical white matter, which is undergoing normal myelination or is fully myelinated 37,38 . For STIR images, the specific parameters needed for myelin attenuation are generally determined for individual systems 39,40 . We did not conduct a trial to optimize contrast in STIR images, rather we used those based on prior experience in adult dogs.…”

Section: Discussionmentioning

confidence: 99%

Normal Canine Brain Maturation at Magnetic Resonance Imaging

Gross¹,

Garcia-Tapia

Riedesel³

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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The normal neonatal canine brain exhibits marked differences from that of the mature brain. With development into adulthood there is a decrease in relative water content and progressive myelination; these changes are observable with magnetic resonance (MR) imaging and are characterized by a repeatable and predictable time course. We characterized these developmental changes on common MR imaging sequences and identified clinically useful milestones of transition. To accomplish this, 17 normal dogs underwent MR imaging of the brain at various times after birth from 1 to 36 weeks. Sequences acquired were T1-weighted, T2-weighted, Fluid Attenuated Inversion Recovery, Short Tau Inversion Recovery and Diffusion Weighted Imaging sequences. The images were assessed subjectively for gray and white matter relative signal intensity and results correlated with histologic findings. The development of the neonatal canine brain follows a pattern that qualitatively matches that observed in humans, and which can be characterized adequately on T1-weighted and T2-weighted images. At birth, the relative gray matter to white matter signal intensity of the cortex is reversed from that of the adult with an isointense transition at 3–4 weeks on T1-weighted and 4–8 weeks on T2-weighted images. This is followed by the expected mature gray matter to white matter relative intensity that undergoes continued development to a mostly adult appearance by 16 weeks. On the Fluid Attenuated Inversion Recovery sequence the cortical gray and white matter exhibit an additional signal intensity reversal during the juvenile period that is due to the initial high relative water content at the subcortical white matter, with its marked T1 relaxation effect.

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Section: Discussionmentioning

confidence: 99%

Normal Canine Brain Maturation at Magnetic Resonance Imaging

Gross¹,

Garcia-Tapia

Riedesel³

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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“…4) The IR technique has had a number of limitations such as long acquisition times, but acquisition times have been significantly reduced by the combined use of fast scan techniques such as fast or turbo SE imaging, and the IR technique is now widely employed for imaging of lesions of the head and neck 13) and the central nervous system. 1,7,16) The present study acquired images of gliomas using fast IR, which is a pulse sequence combining the IR and fast SE techniques and the real reconstruction method, to compare the usefulness of fast IR with conventional T 1 -weighted SE MR imaging techniques for the evaluation of patients with gliomas.…”

Section: Introductionmentioning

confidence: 99%

Fast Inversion Recovery Magnetic Resonance Imaging with the Real Reconstruction Method: A Diagnostic Tool for Cerebral Gliomas.

Bandai

Tsunoda

Mitsuoka

et al. 2002

Neurol. Med. Chir.(Tokyo)

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The fast inversion recovery (IR) technique was evaluated for the localization of gliomas. Fast IR imaging with real reconstruction and T 1 -weighted spin echo (SE) imaging before and after contrast administration were performed in 20 patients with gliomas. The tumor-to-white matter contrast ratio (TWCR), tumor-to-gray matter contrast ratio (TGCR), tumor-to-white matter contrast-to-noise ratio (TWCNR), and tumor-to-gray matter contrast-to-noise ratio (TGCNR) were calculated and compared. Fast IR imaging visualized tumors with significantly higher TWCR, TGCR, TWCNR, and TGCNR values (p º 0.01) than those for T 1 -weighted SE imaging. In particular, fast IR imaging clearly revealed seven nonenhanced tumors that were poorly visualized on T 1 -weighted SE imaging. Fast IR imaging showed a similar TGCR and significantly higher TWCR (p º 0.01) compared to T 1 -weighted SE imaging with contrast medium in 13 enhanced tumors. However, fast IR imaging showed similar TWCNR and lower TGCNR compared to T 1 -weighted SE imaging with contrast medium. The fast IR technique can discriminate tumors from normal cerebral tissues with high contrast and without the use of contrast medium. This technique is extremely useful for the localization of non-enhanced tumors.

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