Fast Inversion Recovery for Myelin Suppression (FIRMS)

Wolansky, Leo; Chiang, Peter K.; Liu, Wen‐Ching; Gonzales, Reynaldo N.; Holodny, Andrei I.; Baker, Stephen R.

doi:10.1111/jon199773176

Cited by 5 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Double inversion recovery (DIR) is a MRI sequence wherein signal from the cerebrospinal fluid is suppressed (as with FLAIR) 9 . In addition, white matter signal is suppressed as with fast inversion recovery for myelin suppression 10 . As a result, the gray matter and inflammatory lesions are highlighted as hyperintense.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Double inversion recovery to detect cervical spinal cord multiple sclerosis lesions

Patel

Dimaandal

Kuhns

et al. 2023

Journal of Neuroimaging

View full text Add to dashboard Cite

Background and Purpose Magnetic resonance imaging (MRI) plays a key role in diagnosing and monitoring multiple sclerosis (MS). Double inversion recovery (DIR) is a pulse sequence that has proven highly effective at detecting cortical lesions but is understudied in the spinal cord. We hypothesize that DIR images obtained during brain MRI can be of value in assessing the upper spinal cord of MS patients. Methods We retrospectively examined brain MRI exams of 64 patients with established MS, who had also undergone cervical spine MRI. Two blinded MS expert readers, who assessed the scans for lesion numbers and rated lesion visibility and overall image quality, reviewed brain 3‐dimensional DIR sagittal and coronal images. Standardized mean contrast‐to‐noise ratios (C/N) and standard deviation (SD) were calculated in representative lesions for each patient and compared to those of 3‐dimensional FLAIR images. Results For the analysis of lesions categorized as “definite lesions,” the sensitivity was 87%, specificity was 61%, and negative predictive value was 80%. On the other hand, for “definite” plus “probable” lesions, the sensitivity was 91%, the specificity was 54%, and negative predictive value was 86%. DIR demonstrated lesions with an average C/N of 7.56 with an SD of 1.77. FLAIR sequence demonstrated lesions with an average C/N of 0.67 and SD of 1.27. Conclusions Sagittally acquired brain DIR can provide useful information on upper spinal cord lesions, with high C/N. In theory, this should facilitate the attainment of McDonald's or the Magnetic Resonance Imaging in MS (MAGNIMS) criteria in some cases, without a dedicated cervical spine MRI exam.

show abstract

Section: Introductionmentioning

confidence: 99%

“…9 In addition, white matter signal is suppressed as with fast inversion recovery for myelin suppression. 10 As a result, the gray matter and inflammatory lesions are highlighted as hyperintense. DIR has been shown to be sensitive and specific, particularly in evaluation of cerebral cortical/juxtacortical demyelinating lesions.…”

Section: Introductionmentioning

confidence: 99%