Fast Inhibitory Transmission of Pain in the Spinal Cord

Zeilhofer, Hanns Ulrich; Witschi, Robert; Johansson, Torbjörn

doi:10.1007/978-1-4419-0226-9_3

Cited by 4 publications

(3 citation statements)

References 87 publications

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“…Comparative analyses of GABA-positive and glycine-positive neurons revealed that approximately 30-50% of superficial dorsal horn neurons are GABAergic and about half of these are also immunoreactive for glycine (350, 369, 372). These observations have largely been confirmed by in-situ hybridization studies (162) and in mice expressing EGFP in glycinergic neurons (419, 420) (Figure 7C).…”

Section: Distribution Of Presynaptic Elements Of Gabaergic and Glysupporting

confidence: 63%

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

Zeilhofer

Wildner

Yévenes

2012

Physiological Reviews

Self Cite

327

312

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The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy conditions, they limit the excitability of spinal terminals of primary sensory nerve fibers and of intrinsic dorsal horn neurons through pre- and postsynaptic mechanisms, and thereby facilitate the spatial and temporal discrimination of sensory stimuli. Removal of fast inhibition not only reduces the fidelity of normal sensory processing but also provokes symptoms very much reminiscent of pathological and chronic pain syndromes. This review summarizes our knowledge of the molecular bases of spinal inhibitory neurotransmission and its organization in dorsal horn sensory circuits. Particular emphasis is placed on the role and mechanisms of spinal inhibitory malfunction in inflammatory and neuropathic chronic pain syndromes.

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Section: Distribution Of Presynaptic Elements Of Gabaergic and Glysupporting

confidence: 63%

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

Zeilhofer

Wildner

Yévenes

2012

Physiological Reviews

Self Cite

327

312

View full text Add to dashboard Cite

show abstract

“…In parallel, we stained for GAD67 to define the borders of lamina III. Previous studies demonstrated that transgenic GAD67-GFP mice predominately labels neurons laminae I-III (Zeilhofer et al, 2009), and we found strong colocalization of Lfng-GFP with GAD67 (Fig. 1R).…”

Section: Resultssupporting

confidence: 76%

Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing

et al. 2021

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Astrocytes are the most abundant glial cell in the brain and perform a wide range of tasks that support neuronal function and circuit activities. There is emerging evidence that astrocytes exhibit molecular and cellular heterogeneity; however, whether distinct subpopulations perform these diverse roles remains poorly defined. Here we show that the Lunatic Fringe-GFP (Lfng-GFP) bacteria artificial chromosome mouse line from both sexes specifically labels astrocyte populations within lamina III and IV of the dorsal spinal cord. Transcriptional profiling of Lfng-GFP 1 astrocytes revealed unique molecular profiles, featuring an enriched expression of Notch-and Wnt-pathway components. Leveraging CRE-DOG viral tools, we ablated Lfng-GFP 1 astrocytes, which decreased neuronal activity in lamina III and IV and impaired mechanosensation associated with light touch. Together, our findings identify Lfng-GFP 1 astrocytes as a unique subpopulation that occupies a distinct anatomic location in the spinal cord and directly contributes to neuronal function and sensory responses.

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“…It is almost generally accepted that neuronal and synaptic plasticity occurring at different levels of the neuraxis are major contributors to chronic pain (Luo, Kuner, & Kuner, 2014;Sandk€ uhler, 2009;Zeilhofer, Witschi, & Johansson, 2009) (for a schematic illustration of the pain pathway, see Fig. 1).…”

Section: Introductionmentioning

confidence: 99%