Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries

Keçili, Rüstem; Billing, Johan; Nivhede, David; Sellergren, Börje; Rees, Anthony T.; Yilmaz, Ecevit

doi:10.1016/j.chroma.2014.02.073

Cited by 40 publications

(16 citation statements)

References 33 publications

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“…Regarding SPE results the SRSH produced in this current research showed a better response than that presented by Rustem et al and Cummins et al The adsorption capacity q of MIHs synthesized ( c . 6000 mmol kg −1 ) in this current work is 1000 times higher than q quoted by Liu Xueyong et al ( c .…”

Section: Resultscontrasting

confidence: 50%

“…To our best knowledge none carried out research in synthesizing smart hydrogels microparticles integrating CRP and imprinting processes for the best possible outcome. The highlight of this current research is starting from synthesis to end product analysis, water was used as solvent, whereas other researchers have quoted the use of dimethylformamide (DMF), chloroform (CHCl 3 ) and acetonitrile (MeCN) as working solvents (Table ).…”

Section: Resultsmentioning

confidence: 99%

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Molecular imprinting in hydrogels using reversible addition-fragmentation chain transfer polymerization and continuous flow micro-reactor

Kadhirvel

Machado

Freitas

et al. 2015

J. Chem. Technol. Biotechnol.

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Section: Resultscontrasting

confidence: 50%

Section: Resultsmentioning

confidence: 99%

Molecular imprinting in hydrogels using reversible addition-fragmentation chain transfer polymerization and continuous flow micro-reactor

Kadhirvel

Machado

Freitas

et al. 2015

J. Chem. Technol. Biotechnol.

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“…The target was to obtain a sufficiently selective material that displayed recognition of particular genotoxic compounds [21]. Genotoxic compounds are a collection of different compound classes that may be present in pharmaceutical APIs.…”

Section: Development Of a Mip Selective Towards Genotoxic Compoundsmentioning

confidence: 99%

Utilizing the Cross-Reactivity of MIPs

Yilmaz¹,

Billing²,

Nilsson³

et al. 2015

Molecularly Imprinted Polymers in Biotechnology

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The crossreactivity of molecularly imprinted polymers (MIPs) and its practical implications are discussed. Screening of MIP libraries is presented as a fasttrack route to discovery of resins selective towards new targets, exploiting the fact that MIPs imprinted with one type of template molecule also show recognition to related and sometimes also to apparently unrelated molecules. Several examples from our own and others' studies are presented that illustrate this crossreactivity and the pattern of recognition is discussed for selected examples.

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“…5−7 Over the past years, polymer-supported reagents containing hydrazine or semicarbazide groups have been extensively studied and used in various applications to scavenge carbonyl compounds from solutions. 8−14 To investigate the possibility of a novel and low-cost resin for the scavenging of aldehyde and ketones, we previously investigated the synthesis of a resin, named Amb15-Iso, which was obtained from the reaction between a commercial acid resin (Amberlyst-15) and isoniazid (isonicotinic acid hydrazide, CAS: 54-85-3), a drug for tuberculosis treatment. 15 Amb15-Iso is a low-cost resin and has the ability to remove aldehydes and ketones from solutions in a single-step reaction.…”

Section: Introductionmentioning

confidence: 99%

Effects of Solvent Polarity on the Reaction of Aldehydes and Ketones with a Hydrazide-Bound Scavenger Resin

et al. 2019

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Polymer-supported reagents have been extensively studied and used in various applications, such as condensation reactions and multiple component reactions. This paper examines the reactions between a solid-functionalized resin, named Amb15-Iso, and aldehydes and ketones that have been solubilized in different solvents. The reactions between these molecules and a hydrazide (isoniazid) in both neutral and acidic media were also studied. The results showed that the solvent polarity influenced the kinetics of the reaction and the yields of carbonyl compounds that were captured by the resin, particularly, for less-reactive molecules. The reactions using the resin were faster than those using free isoniazid in solution, likely because the acidic sites remaining in the resin can catalyze the reaction, increasing the rate of capture. A high dependence on the presence of acidic compounds and the rate of the reaction was observed, in which trifluoroacetic acid was used to catalyze the reaction between the tested molecules and isoniazid in solution. The differential reactivities of the examined ketones and aldehydes in these condensation reactions demonstrate that the resin can provide selective criteria, preferentially scavenging aldehydes from solution. While benzaldehyde reacted quite quickly with the resin, acetophenone barely had any reaction and remained in solution.

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Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries

Cited by 40 publications

References 33 publications

Molecular imprinting in hydrogels using reversible addition-fragmentation chain transfer polymerization and continuous flow micro-reactor

Molecular imprinting in hydrogels using reversible addition-fragmentation chain transfer polymerization and continuous flow micro-reactor

Utilizing the Cross-Reactivity of MIPs

Effects of Solvent Polarity on the Reaction of Aldehydes and Ketones with a Hydrazide-Bound Scavenger Resin

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