Fast identification of phthalic acid esters in poly(vinyl chloride) samples by Direct Analysis In Real Time (DART) tandem mass spectrometry

Abstract

It was found that the collision energy/voltage necessary to obtain 50% fragmentation (CV 50 ) was linearly dependent on the molecular weight of phthalic acid esters (PAEs). Based on this observation a fast screening technique for the detection of PAEs in Poly Vinyl Chloride (PVC) samples was developed using Direct Analysis in Real Time (DART) ionization tandem mass spectrometry. Based on this observation an automated data acquisition method, including mass-dependent tuning of the collision energy/voltage in DART-MS/MS, was developed thereby reducing the analysis time.

The Anti-Inflammatory Effect of a γ-Lactone Isolated from Ostrich Oil of Struthio camelus (Ratite) and Its Formulated Nano-Emulsion in Formalin-Induced Paw Edema

“…These nanoparticles were made using MC polymer as the outer coating layer. γ-lactone-MC-NPs were prepared as the method stated previously with some modifications [ 32 , 33 ]. Briefly, 1 g of MC was dissolved in 100 mL distilled water and stirred continuously until a clear solution was obtained (Stock solution I).…”

Rapid qualitative analysis of phthalates added to food and nutraceutical products by direct analysis in real time/orbitrap mass spectrometry

“…To exacerbate this issue, the principle fragment of each of these compounds, arising from the loss of one of the hydrocarbon chains, has a protonated accurate mass of m/z 279.1591, which is equivalent to the molecular ion mass [M þ H] of DBP or DIBP, which are also structural isomers, although contribution to this from the fragment is very small compared to the DBP or DIBP contributions. Differentiation of these compounds has previously been possible only by MS/MS experiments (Kuki et al, 2011) but in this case this technique is not available for this instrumentation. However, for the intended use of this method as a regulatory screening tool to determine rapidly if any of these compounds is present, and follow up with more traditional chromatographic methodology for confirmation, a method of this type will be sufficient.…”

“…For the phthalates contamination incidence which occurred in 2011 in Taiwan, the Taiwan Food Authority employed a LC/MS/MS method posted in its phthalates website (Taiwan Food Authority, 2011c) for determination of six phthalates (i.e., BBP, DBP, DEHP, DNOP, DINP, and DIDP). The Direct Analysis in Real Time (DART) ion interface has also recently been shown (Abe et al, 2010;Ackerman, Noonan, & Begley, 2009;Kuki, Nagy, Zsuga, & Kéki, 2011;Rothenbacher & Schwack, 2010) to be effective in analyzing this class of compounds from plastic matrices, and has also been employed in a number of food applications (Hajslova, Cajka, & Vaclavik, 2011). In the current work, we have interfaced this ion source with a Thermo Exactive orbitrap mass spectrometer in order to rapidly analyze a wide variety of beverage/food sample types as well as a selection of nutraceutical samples for these compounds in addition to DIBP.…”

The Use of Augmented Reality Blended Learning for Improving Understanding of Food Security

“…One example of the use of Augmented Reality technology in learning is Augmented Reality to study body anatomy (Jamali et al, 2015). Through Augmented Reality-based applications, students can learn about human organs, for example, the human skull in a three-dimensional form virtually and interact with these virtual objects (Kuki et al, 2011). Furthermore, by using Augmented Reality a student can learn visually and interactively about the earth and space and various underwater life (Lindner et al, 2019).…”