Fast high-resolution metabolite mapping on a preclinical 14.1T scanner using 1H-FID-MRSI

Abstract

1H-MRSI enables a simultaneous acquisition of MR-spectra from multiple spatial locations inside the brain. While 1H-MRSI is increasingly used in the human brain, its implementation in preclinical setting is limited because of the smaller size of rodent brain. At UHF for humans, 1H-FID-MRSI acquisitions are increasingly used (T2 and J-evolution minimization, increased SNR). We present the first implementation of fast 1H-FID-MRSI in the rat brain at 14.1T and exploit its potential for an increased brain coverage, reliable and accurate quantification results and metabolic maps. Our results set the grounds for a wider application of 1H-FID-MRSI in the preclinical setting.