Fast growing myopericytoma of the hand: Case report and literature review

Abstract

Introduction and importance Myopericytoma (MPC) is a rare benign soft tissue neoplasm that arises from perivascular smooth muscle-like myoid cells that share features of both glomus and smooth muscle cells. It usually slow growing solitary tumor that might mimic aggressive sarcoma. Case presentation 45 years old male, with unremarkable medical history, presented with fast growing mass on the left 1st webspace that was noticed 6 months prior to presentation. Investigations with US and MRI showed highly vascular solid mass that was worrisome for malignant lesion. Surgical excision was done and histopathology confirmed the diagnosis of myopericytoma. Clinical discussion MPC is a rare perivascular neoplasm that’s reported mainly in the extremities with lower limbs are most affected sites. Usually it presents as solid painless slowly growing mass. However, Multiple papers reported different rare presentations like multiple, painful and some with malignant transformation. Conclusion MPC is a benign tumor that might mimic aggressive sarcoma. Such cases should be approached with high suspicion and proper investigation and management should be followed promptly.

Pontine Myopericytoma: Case Report and Literature Review

“…It is a soft tissue tumor that originates from perivascular myoid cells and exhibits features of smooth muscle and vascular bulb cells. It is a perivascular tumor along with myofibroma, hemangiopericytoma, and glomangioma ( 2 – 4 ). MPC often occurs in the skin and subcutaneous soft tissues of the extremities, especially in the lower extremities.…”

“…Although most MPCs are benign, there are some instances of malignant MPC ( 4 ). They are generally characterized by active nuclear division, cellular anisotropy, and necrosis ( 11 , 12 ).…”

Multiple Nodules on the Bilateral Lower Extremities: Answer

“…The prognosis of MPC is generally favorable because it is usually benign. 8 However, some cases of malignant MPC have been reported. 6 Such lesions exhibit mitoses, necrosis, and nuclear atypia.…”

“…5 Myopericytomas are typically slowgrowing neoplasms and are usually less than 2 cm in greatest dimension 6 and present as a painless discrete nodule with a gray-white colored appearance on physical examination. 7,8 These nodules can be found in a variety of areas within the body, including the neck, 9 trunk, 9 and nervous system. 10 Biopsy from the opposite thigh in our patient showed similar features, and multicentric cases have been reported.Excision biopsy is optimal for histopathological examination and immunophenotypic evaluation, 11 which shows nodular proliferation of concentric round or ovoid eosinophilic spindle cells with an onion skin pattern.…”

Myopericytoma of the Right Middle Finger: A Case Report of an Uncommon Perivascular Neoplasm

“…They were designated as soft tissue tumors by the World Health Organization (WHO) in 2022 [2]. Typically, MPCs affect the dermis and subcutaneous tissues of the lower extremities [3,4].…”