Fast-Growing Large Cell Neuroendocrine Carcinoma of Mediastinum

Lukina, O. V.; Горбунков, С. Д.; Dvorakovskaja, Ivetta; Varlamov, V V; Akopov, Andrey

doi:10.1016/j.athoracsur.2010.09.065

Cited by 5 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Large-cell neuroendocrine carcinoma (LCNEC) was first reported in the lung (1). LCNECs have since been reported in several locations, including the mediastinum, head and neck, pancreas, gallbladder, intestine and gynecological organs (2,3). Among gynecological organs, LCNECs more frequently occur in the uterine cervix rather than the uterine corpus.…”

Section: Introductionmentioning

confidence: 99%

Large-cell neuroendocrine carcinoma arising in the endometrium: A case report

et al. 2018

View full text Add to dashboard Cite

Large-cell neuroendocrine carcinoma (LCNEC) of the endometrium is an extremely rare, high-grade malignant tumor. We herein report a case of a rapidly growing LCNEC arising in the endometrium. A 52-year-old woman was referred to Toyooka Hospital (Tooyoka, Japan) due to genital bleeding in February 2016. There had been no abnormalities on a regular gynecological and physical examination 3 months prior to the consultation. Imaging (computed tomography and magnetic resonance imaging) and a pelvic examination revealed a tumor sized 16.9×8.4×7.8 mm occupying the intrauterine cavity and extending into the vaginal cavity. Multiple metastatic pelvic and paraaortic lymph nodes were also identified. Continuous bleeding from the tumor was observed, and a blood examination revealed anemia, which was likely due to that bleeding. Biopsy of the tumor was performed, and large atypical cells were identified. The tumor cells were negative for cytokeratin AE1/AE3 and chromogranin A, but positive for CD56 and synaptophysin. There was also an abundance of Ki-67-positive cells in the tumor, altogether suggesting that the tumor was an LCNEC. The patient succumbed to the disease 36 days after the first consultation. Based on the findings of the present case and previously published cases, LCNECs arising in the endometrium may progress rapidly and are associated with an unfavourable outcome. LCNEC should be included in the differential diagnosis in cases of rapidly growing tumors of the uterine corpus.

show abstract

Section: Introductionmentioning

confidence: 99%

Large-cell neuroendocrine carcinoma arising in the endometrium: A case report

et al. 2018

View full text Add to dashboard Cite

show abstract

Neuroendocrine Tumors (NETs) of the Mediastinum and Thymus

Diffalha

Khalil

2016

Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances

View full text Add to dashboard Cite

Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum

Maeda¹,

Nakata²,

Yasuda³

et al. 2012

Gen Thorac Cardiovasc Surg

View full text Add to dashboard Cite

Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum is extremely rare. In this report, we present a case of a 53-year-old man with superior vena cava (SVC) syndrome who developed LCNEC in the middle mediastinum. His chief complaint was facial edema. Chest X-ray revealed an abnormal shadow in the right upper mediastinum. Computed tomography (CT) scan of the chest revealed a 67-mm mass in the middle mediastinum. Tumor invasion caused constriction of the SVC. The patient underwent induction chemoradiotherapy with vinorelbin and cisplatin and concurrent radiation therapy. After induction therapy, the tumor size decreased remarkably and was resected completely. The pathological diagnosis was LCNEC.

show abstract

Fast-Growing Large Cell Neuroendocrine Carcinoma of Mediastinum

Cited by 5 publications

References 8 publications

Large-cell neuroendocrine carcinoma arising in the endometrium: A case report

Large-cell neuroendocrine carcinoma arising in the endometrium: A case report

Neuroendocrine Tumors (NETs) of the Mediastinum and Thymus

Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum

Contact Info

Product

Resources

About