Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept

Abbas, Hassan; Broche, Lionel; Ezdoglian, Aiarpi; Li, Dmitriy; Ross, P. James; Cheyne, Lesley; Lurie, David John; Dawson, Dana

doi:10.1016/j.jmr.2020.106722

Cited by 6 publications

(9 citation statements)

References 68 publications

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“…For example, inflammatory macrophages show a noticeable ability to uptake magnetic nanoparticles, a process that is very attractive for MRI-based diagnosis. Moreover, quantitative assessment of intra-cellular magnetic nanoparticles can be achieved by field-cycling NMR relaxometry [23].…”

Section: Introductionmentioning

confidence: 99%

Fast iron oxide-induced low-field magnetic resonance imaging

Rodriguez¹,

Erro²,

Anoardo³

2020

J. Phys. D: Appl. Phys.

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Dynamic images acquired by proton fast field-cycling magnetic resonance imaging are presented for the first time. Image contrast mediated by superparamagnetic iron oxide nanoparticles and weighted by the spin-lattice (T1) relaxation time, and both spin-lattice and spin-spin (T2) relaxation times, are discussed. Image acquisition and processing within 8 s is allowed for real-time recording of exemplary physical situations evolving in a compatible time-scale. Two simple examples are shown with the corresponding videos assembled by sequencing the acquired images. Fast iron oxide-induced low-field magnetic resonance imaging (MRI) constitutes the first step in the development of field-cycling functional MRI for biomedical and physical applications.

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Section: Introductionmentioning

confidence: 99%

Fast iron oxide-induced low-field magnetic resonance imaging

Rodriguez¹,

Erro²,

Anoardo³

2020

J. Phys. D: Appl. Phys.

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“…Combining imaging methods (e.g., PET-CMR) may provide additional insights into the pathophysiology of myocarditis. All modalities have the potential to target specific cells and proteins of inflammation: echocardiography using molecular bubble contrast; PET focusing upon metabolic macrophages; and CMR utilizing nanoparticles of iron oxide [ 106 , 113 ]. Imaging-directed endomyocardial biopsy may improve the sampling diagnostic yield (e.g., interventional CMR methods).…”

Section: Diagnostic Imaging For Myocarditismentioning

confidence: 99%

Meeting the Challenges of Myocarditis: New Opportunities for Prevention, Detection, and Intervention—A Report from the 2021 National Heart, Lung, and Blood Institute Workshop

Čiháková

Shi

Adhikari

et al. 2022

JCM

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The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of international experts to discuss new research opportunities for the prevention, detection, and intervention of myocarditis in May 2021. These experts reviewed the current state of science and identified key gaps and opportunities in basic, diagnostic, translational, and therapeutic frontiers to guide future research in myocarditis. In addition to addressing community-acquired myocarditis, the workshop also focused on emerging causes of myocarditis including immune checkpoint inhibitors and SARS-CoV-2 related myocardial injuries and considered the use of systems biology and artificial intelligence methodologies to define workflows to identify novel mechanisms of disease and new therapeutic targets. A new priority is the investigation of the relationship between social determinants of health (SDoH), including race and economic status, and inflammatory response and outcomes in myocarditis. The result is a proposal for the reclassification of myocarditis that integrates the latest knowledge of immunological pathogenesis to refine estimates of prognosis and target pathway-specific treatments.

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“…The blood circulation time and biodistribution are needed to be specifically considered for the subsequent applications. In this context, long blood circulation time and reduced organ accumulation of USPIO nanoparticles undoubtedly make them potent candidates for a wide range of MRI applications, for example, blood pool imaging (Sandiford et al, 2013; Tromsdorf et al, 2009; Wei et al, 2017), tumor imaging (Du et al, 2020; D. Liu et al, 2020; Shi et al, 2020; Song et al, 2013; C. Yang et al, 2019; Zhang et al, 2020), atherosclerosis imaging (Alam et al, 2015; Ruetten et al, 2020; Usman et al, 2015), and inflammation imaging (Abbas et al, 2020; Lagan et al, 2020; Luo et al, 2020).…”

Section: Applications Of Uspio Nanoparticlesmentioning

confidence: 99%

Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging

Chen

Gao

et al. 2021

WIREs Nanomed Nanobiotechnol

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As a research hotspot, the development of magnetic resonance imaging (MRI) contrast agents has attracted great attention over the past decades for improving the accuracy of diagnosis. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles with core diameter smaller than 5.0 nm are expected to become a next generation of contrast agents owing to their excellent MRI performance, long blood circulation time upon proper surface modification, renal clearance capacity, and remarkable biosafety profile. On top of these merits, USPIO nanoparticles are used for developing not only T 1 contrast agents, but also T 2 /T 1 switchable contrast agents via assembly/disassembly approaches. In recent years, as a new type of contrast agents, USPIO nanoparticles have shown considerable applications in the diagnosis of various diseases such as vascular pathological changes and inflammations apart from malignant tumors. In this review, we are focusing on the state-of-the-art developments and the latest applications of USPIO nanoparticles as MRI contrast agents to discuss their advantages and future prospects. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imagingcontrast agents, iron oxide nanoparticles, magnetic resonance imaging, ultrasmallCan Chen and Jianxian Ge contributed equally to this study.

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Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept

Cited by 6 publications

References 68 publications

Fast iron oxide-induced low-field magnetic resonance imaging

Fast iron oxide-induced low-field magnetic resonance imaging

Meeting the Challenges of Myocarditis: New Opportunities for Prevention, Detection, and Intervention—A Report from the 2021 National Heart, Lung, and Blood Institute Workshop

Ultrasmall superparamagnetic iron oxide nanoparticles: A next generation contrast agent for magnetic resonance imaging

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