Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus

Macı́as, Juan; Berenguer, Juan; Japón, Miguel Á.; Giron, J; Rivero, Antonio; López‐Cortés, Luis F.; Moreno, Ana; González-Serrano, Mercedes; Iribarren, José Antonio; Ortega, Enrique; Miralles, Pilar; Mira, José A.; Pineda, Juan A.

doi:10.1002/hep.23136

Cited by 241 publications

(212 citation statements)

References 26 publications

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“…We also evaluated changes in liver fibrosis at fixed intervals, at 3 and 5 years after liver transplantation, in relation to clinical decompensation, in order to make the time frame for evaluation more homogenous. The Ishak stage change calculation was evaluated as it has been used to assess fibrosis progression in the literature and we wished to compare our results with those of others [15,16] [2]. However, we acknowledge that since Ishak stage scores are not numerical measurements, without an arithmetical relationship between them (the ''scores'' are merely categorical labels), this method is an approximation [1][2][3].…”

Section: Methodsmentioning

confidence: 99%

Digital image analysis of collagen assessment of progression of fibrosis in recurrent HCV after liver transplantation

Manousou¹,

Burroughs²,

Sochatzis³

et al. 2013

Journal of Hepatology

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Section: Methodsmentioning

confidence: 99%

Digital image analysis of collagen assessment of progression of fibrosis in recurrent HCV after liver transplantation

Manousou¹,

Burroughs²,

Sochatzis³

et al. 2013

Journal of Hepatology

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“…In patients with chronic HCV infection, concomitant HIV infection is associated with higher rates of morbidity and mortality related to end-stage liver disease [11].…”

Section: Discussionmentioning

confidence: 99%

HIV Prevalence among HCV Egyptian Infected Patients and Its Impact on the Result of HCV Treatment

Fouad¹,

Shaker²,

Hafez³

et al. 2013

AID

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Background and Aim of the Study: HCV infection is the most common co-infection in HIV patients so we aimed to determine the prevalence of HIV infection in chronic HCV patients and its impact on chronic HCV patients treatment response. Patients and Methods: A retrospective study performed on 1852 chronic HCV patients subjected to anti HCV treatment with alpha 2a, alpha 2b or standard interferon and Ribavirin and tested and confirmed for HIV co infection by ELISA twice. Upon HIV testing, two groups were generated, Group 1: 1840 HCV patients, positive for HCV RNA, and Group 2: 12 HIV positive patients and positive also for HCV. Informed consents were obtained from patients. Proper hematological biochemical investigations and other causes of hepatitis rather than HCV were carried out and excluded. Results: The prevalence of HIV among HCV infected Egyptian patients was 0.64%. We found a male gender predominance; the hematological and biochemical parameters were similar in both groups with mild elevations in liver enzymes in group II. High rates of failure to treatment (77.8%) with lower SVR (22.2%) were in group II compared to group I (59.9%) as SVR was 22.1% in group II vs. 34.1% in group I, however with no statistical significance. Conclusion: Despite the lower prevalence of HIV in Egyptian patients with HCV infection, it still affects their response to treatment .Therefore; we must screen HIV in all HCV patients and recommend its test to routine investigations before starting HCV therapy.

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“…Olgumuzda da ilk başvuruda CD4 T-lenfosit sayısı <200 hücre/mm3 olduğundan öncelikle ART başlandı, HCV tedavisi ertelendi, CD4 T-lenfosit sayısı yükseldikten sonra tedavi planlandı. Antiretroviral tedavinin immünfonksiyonları düzenlemek yoluyla karaciğer hastalığının progresyonunu yavaşlattığı bilinmektedir (23)(24)(25). Bu nedenle de KHC varlığında CD4 T-lenfosit sayısından bağımsız olarak ART önerilmektedir.…”

Section: Discussionunclassified

HIV/HCV Koenfeksiyonu: Olgu Sunumu

Karaosmanoğlu¹,

Aydın²,

İnce³

et al. 2013

Vhd

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Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus

Cited by 241 publications

References 26 publications

Digital image analysis of collagen assessment of progression of fibrosis in recurrent HCV after liver transplantation

Digital image analysis of collagen assessment of progression of fibrosis in recurrent HCV after liver transplantation

HIV Prevalence among HCV Egyptian Infected Patients and Its Impact on the Result of HCV Treatment

HIV/HCV Koenfeksiyonu: Olgu Sunumu

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