Fast-Embeddable Grooved Microneedles by Shear Actuation for Accurate Transdermal Drug Delivery

Abstract

Percutaneous drug delivery using microneedles (MNs) has been extensively exploited to increase the transdermal permeability of therapeutic drugs. However, it is difficult to control the precise dosage with existing MNs and they need to be attached for a long time, so a more simple and scalable method is required for accurate transdermal drug delivery. In this study, we developed grooved MNs that can be embedded into the skin by mechanical fracture following simple shear actuation. Grooved MNs are prepared from hyaluronic acid (HA), which is a highly biocompatible and biodegradable biopolymer. By adjusting the aspect ratio (length:diameter) of the MN and the position of the groove, the MN tip inserted into the skin can be easily broken by shear force. In addition, it was demonstrated that it is possible to deliver the desired amount of triamcinolone acetonide (TCA) for alopecia areata by controlling the position of the groove structure and the concentration of TCA loaded in the MN. It was also confirmed that the tip of the TCA MN can be accurately delivered into the skin with a high probability (98% or more) by fabricating an easy-to-operate applicator to provide adequate shear force. The grooved MN platform has proven to be able to load the desired amount of a drug and deliver it at the correct dose.

Novel Drug Delivery Systems: An Important Direction for Drug Innovation Research and Development

“…By fabricating an easy-tooperate applicator that provides adequate shear force, the tip of TCA-MN can be accurately delivered to the skin with a high probability (98% or more). The grooved MN platform has been proven capable of loading the required amount of drug and delivering it in the correct dosage [211]. A glucose-responsive "closed-loop" insulin delivery system that mimics the function of pancreatic cells has the potential to significantly improve the quality of life and health status of diabetic patients.…”