Fast disintegrating tablet of Valsartan for the treatment of pediatric hypertension: In vitro and in vivo evaluation

Husseiny, Rabab A.; Lila, Amr S. Abu; Abdallah, Marwa H.; Elghamry, Hanaa A.

doi:10.1016/j.jddst.2017.10.014

Cited by 24 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study conducted by Husseiny et al [25], valsartan was formulated into a fast disintegrating tablet using sodium starch glycolate and crospovidone in different concentrations. According to recent research, valsartan proved to be a promising candidate for the treatment of pediatric hypertension, especially in patients suffering from either diabetes or renal impairment [26].…”

Section: Disintegrantsmentioning

confidence: 99%

“…The fast disintegrating tablet formulations exhibited an antihypertensive effect after only 15 min post administration, whereas the oral suspension formulation exhibited the first sign of antihypertensive action 60 min after oral administration. The early disintegration and release of active ingredient from the fast disintegrating tablet formulations contributed to the early onset of action and was most likely mediated by faster and more efficient absorption of valsartan [25].…”

Section: Disintegrantsmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

et al. 2020

View full text Add to dashboard Cite

Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The oral bioavailability of these compounds is usually very low as a result of their poor solubility properties. In order to improve the bioavailability of these poorly soluble drugs, formulation strategies have been applied as a means to improve their aqueous solubility and dissolution rates. With respect to formulation approaches, excipients can be incorporated in the formulation to assist in the dissolution process of the drug, or specialized dosage forms can be formulated that improve dissolution rate through various mechanisms. This paper provides an overview of selected excipients (e.g., alkalinizing agents, surfactants and sugars) that can be used in formulations to increase the dissolution rate as well as specialized dosage forms such as self-emulsifying delivery systems and formulation techniques such as inclusion complexes and solid dispersions. These formulation approaches are discussed with available examples with specific reference to positive outcomes in terms of drug solubility and bioavailability enhancement.

show abstract

Section: Disintegrantsmentioning

confidence: 99%

Section: Disintegrantsmentioning

confidence: 99%

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Nowadays, tablet is still among the favorite forms of commercial drugs for treating diseases [11][12][13].It has used to Carr's plant extract to be used as an anti-microbial agent, supplement and even as an anti-cancer agent [14][15][16]. Tablets are obtained from the aggregation of powder by applying pressure during the process.…”

Section: -1mentioning

confidence: 99%

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

Irawaty

Hadisoewignyo

Wijaya

et al. 2019

EXPLORING RESOURCES, PROCESS AND DESIGN FOR SUSTAINABLE URBAN DEVELOPMENT: Proceedings of the 5th International Conference on E

View full text Add to dashboard Cite

Dried kaffir lime peels from Citrus hystrix were extracted with ethanol by maceration method, followed by solvent evaporation to obtain dry extract. Due to economical aspect and good flow properties of the extract, a direct compression method was applied in making the tablets. The main objective of this study was to study the influence of filler-binder (Avicel PH 102, Emcompress and Lactose) on rheological properties of kaffir lime peel extract tablet dough. Firstly, kaffir lime peel extract was prepared by peeling, cutting and drying kaffir lime peels prior to soaking them to ethanol. After separating the solid part, the extract was subsequently concentrated and filler was added into the crude extract to obtain dry product. Secondly, dry extract was then combined with filler-binder, sweetener and lubricant prior to the compression. Rheological properties evaluated in this study were density, flow time, the Carr index and the Hausner ratio. Thirdly, the best formulation dough was compressed to produce tablets. From the results, it can be concluded that ethanol is the best solvent to extract polyphenols from kaffir lime peels. In addition, the use of a mixture of lactose and Avicel PH 102 as the filler-binder agent exhibited the best formulation.

show abstract

“…The oral route represents the most common route of drug administration; self-medication, accurate dosing, lack of pain, low cost and patient compliance are the main reasons for choosing this route, when possible [13,17]. Orodispersible tablets are easy to administer and suitable for children and people with dysphagia because do not require any additional water and have a rapid dispersion [4,15]. The drug bioavailability can be significantly higher than the one observed from the classical tablet dosage form [3,5].…”

Section: Introductionmentioning

confidence: 99%

FORMULATION OF ORODISPERSIBLE TABLETS CONTAINING PARACETAMOL AND THEIR IN VITRO CHARACTERIZATION – A QbD APPROACH

Muntean¹

2020

FARMACIA

View full text Add to dashboard Cite

Quality by Design (QbD) concept in drug formulation and development was introduced in order to achieve and ensure a proper product quality through a good process understanding. By identifying the variability sources that influence the product characteristics, the product quality can be built from the development phase. By applying this concept, in the present experimental work was intended to develop and evaluate orodispersible tablets (ODTs) with paracetamol. In order to reach a good balance between their properties: quick disintegration, convenient hardness and a fast drug release, a statistical method was used. 36 formulations were prepared according to a D-optimal experimental design. The formulation factors used in the design were: the type of the diluent agent, the type of disintegrate agent, and the percentages of the disintegrant, sweetener and flavour. The obtained tablets were analysed in vitro for their friability, disintegration time, wetting time and dissolution profile. During this experiment it was observed that the mechanical properties were mainly influenced by the type of diluent agent used, the disintegrant agent and it's ratio in each formulation. The percentage of sweetener and flavour also influenced the dissolution profile, beside the other formulation variables. QbD approach was successfully applied within this study and the ODTs with paracetamol that have desired pharmaceutical characteristics may be successfully prepared. RezumatConceptul de calitate prin design (QbD) a fost introdus în formularea şi dezvoltarea medicamentelor pentru a obţine şi a asigura o calitate adecvată produsului, având la bază o mai bună înţelegere a procesului. Calitatea produsului poate fi construită din faza de dezvoltare a acestuia, prin identificarea surselor de variabilitate care îi pot influenţa caracteristicile. Aplicând acest concept, în prezenta lucrare s-a urmărit obţinerea şi caracterizarea unor comprimate orodispersabile cu paracetamol, care să prezinte o dezagregare rapidă, o bună rezistenţă mecanică şi un profil de cedare in vitro optim. Pentru acest lucru s-au preparat 36 de tipuri de comprimate, conform unui plan experimental de optimizare. Variabilele de formulare au fost: tipul de diluant, tipul de dezagregant şi procentele de dezagregant, ȋndulcitor şi aromatizant. În vederea obţinerii unor variabile de răspuns, comprimatele au fost evaluate in vitro. Au fost evaluate friabilitatea, dezagregarea, rezistenţa mecanică, timpul de umectare şi profilul de dizolvare. Friabilitatea, dezagregarea şi rezistenţa mecanică au fost influenţate de tipul excipientului diluant folosit, de dezagregantul utilizat, dar şi de concentraţia acestuia. Profilul de dizolvare a fost influ enţat, pe lângă factorii amintiţi anterior şi de procentul de îndulcitor sintetic, dar şi de concentraţia aromatizantului. Conceptul de calitate prin design a fost aplicat cu succes acestui studiu, comprimatele orodispersabile obţinute având caracteristicile dorite.

show abstract

Fast disintegrating tablet of Valsartan for the treatment of pediatric hypertension: In vitro and in vivo evaluation

Cited by 24 publications

References 30 publications

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

FORMULATION OF ORODISPERSIBLE TABLETS CONTAINING PARACETAMOL AND THEIR IN VITRO CHARACTERIZATION – A QbD APPROACH

Contact Info

Product

Resources

About