Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography–mass spectrometry

Deng, Chunhui; Ji, Jie; Li, Ning; Yu, Yong; Duan, Gengli; Zhang, Xiangmin

doi:10.1016/j.chroma.2006.03.066

Cited by 84 publications

(52 citation statements)

References 26 publications

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“…The chemical basis of R. curcumae is actively being investigated, and its main constituents are typically classified into the nonvolatile phenolic pigment and the volatile essential oil. The former includes curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] and its analogs, whereas the latter mainly includes two sesquiterpene compounds, curcumol [(3S,5S,6S,8aS)-3-methyl-8-methylidene-5-(propan-2-yl) octahydro-6H-3a,6-epoxyazulen-6-ol] and curdione [(3S,6E,10S)-6,10-dimethyl-3-propan-2-ylcyclodec-6-ene-1,4-dione] (Xia et al, 2005;Deng et al, 2006). Generally, the volatile essential oil is considered as the active constituent mediating many pharmacological properties of the plant such as cognition enhancement , neuroprotection (Dohare et al, 2008), and antiepilepsy efficacy (Wang and Zhao, 2004).…”

Section: Introductionmentioning

confidence: 99%

Subunit-Specific Inhibition of Glycine Receptors by Curcumol

Wang¹,

Li²,

Huang³

et al. 2012

J Pharmacol Exp Ther

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Emerging evidence has suggested that inhibitory glycine receptors (GlyRs) are an important molecular target in the treatment of numerous neurological disorders. Rhizoma curcumae is a medicinal plant with positive neurological effects. In this study, we showed that curcumol, a major bioactive component of R. curcumae, reversibly and concentration-dependently inhibited the glycine-activated current (I Gly ) in cultured rat hippocampal neurons. The inhibitory effect was neither voltage-nor agonist concentration-dependent. Moreover, curcumol selectively inhibited homomeric ␣2-containing, but not ␣1-or ␣3-containing, GlyRs. The addition of ␤ subunit conferred the curcumol sensitivity of ␣3-containing, but not ␣1-containing, GlyRs. Sitedirected mutagenesis analysis revealed that a threonine at position 59 of the ␣2 subunit is critical for the susceptibility of GlyRs to curcumol-mediated inhibition. Furthermore, paralleling a decline of ␣2 subunit expression during spinal cord development, the degree of I Gly inhibition by curcumol decreased with prolonged culture of rat spinal dorsal horn neurons. Taken together, our results suggest that the GlyRs are novel molecular targets of curcumol, which may underlie its pharmaceutical effects in the central nervous system.

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Section: Introductionmentioning

confidence: 99%

Subunit-Specific Inhibition of Glycine Receptors by Curcumol

Wang¹,

Li²,

Huang³

et al. 2012

J Pharmacol Exp Ther

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“…Besides, compared to other modern extraction techniques such as supercritical fluid extraction and pressurized liquid extraction, MAE is easier to use and the systems are cheaper [17][18][19]. Thanks to these advantages, MAE has attracted growing interest in the extraction of active compounds from various matrices, such as plant samples [14,16,20], animal tissues [10,15], sewage sludge [13], human serum [19] cigarettes [21] and fruits [22,23].…”

Section: Introductionmentioning

confidence: 99%

Nitrogen‐protected microwave‐assisted extraction of ascorbic acid from fruit and vegetables

Chen

et al. 2009

J of Separation Science

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In this study, nitrogen-protected microwave-assisted extraction (NPMAE), in which microwave-assisted extraction was performed under nitrogen protection, was initially developed and combined with HPLC separation for the determination of ascorbic acid (AA), an oxidizable component, from fruit and vegetables. The extraction conditions of NPMAE were investigated by extraction of AA from guava, and the chosen conditions were as follows: extraction solvent of 0.25% metaphosphoric acid solution, solid/liquid ratio of 1:10 g/mL, microwave power of 400 W and irradiation time of 10 min. Subsequently, this novel NPMAE method was evaluated by extraction of AA from different fruit and vegetables, such as guava, yellow pepper, green pepper and cayenne pepper. Compared with conventional MAE and solvent extraction methods, the oxidation of AA was significantly reduced or prevented in the process of NPMAE, providing higher extraction yield of AA. These results suggested the potential of NPMAE method for the extraction of oxidizable compounds from different spices of matrices.

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“…In addition, there were several kinds of low concentration terpenes oxygen derivatives, alcohols and carbonyl compounds in the volatile compounds. When compared with the conventional extraction and concentration methods, most of which involve several tedious and time-consuming sample preparation procedures, MAE-HS-SPME is indeed a simple, time-saving and solvent-free, and so on [20,21,38,39].…”

Section: Analysis Of the Volatile Compounds In P Furcata Roylementioning

confidence: 99%

Rapid determination of volatile composition from Polygala furcata Royle by MAE–HS-SPME followed by GC–MS

Zhou

Mao

Long

et al. 2010

Eur Food Res Technol

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Based on microwave-assisted extraction (MAE) and headspace solid-phase microextraction (HS-SPME) followed by gas chromatography mass spectrometry (GC-MS) was developed for the fast determination of volatile chemical compositions of Polygala furcata Royle, the experimental parameters of the MAE-HS-SPME were optimized by orthogonal experimental design. The results indicated that the optimum condition of the determination of the volatile compounds in P. furcata Royle. was achieved with the experimental parameters including microwave power of 400 W and irradiation time of 4 min, sample size 2.0 g. Under the optimal conditions, for the Wrst time, 52 volatile compounds were separated and identiWed from the fresh plants of P. furcata Royle. The highest content component of the 52 compounds was 2-hydroxybenzoic acid methyl ester (21.65%). The relative standard deviation values <7% showed that the method of MAE-HS-SPME followed by GC-MS has good precision. The experimental results demonstrated that it is a simple, time-saving and solvent-free method, and it is a potential analytic tool for the determination of the volatile compounds of the vegetations materials and other materials.

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Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography–mass spectrometry

Cited by 84 publications

References 26 publications

Subunit-Specific Inhibition of Glycine Receptors by Curcumol

Subunit-Specific Inhibition of Glycine Receptors by Curcumol

Nitrogen‐protected microwave‐assisted extraction of ascorbic acid from fruit and vegetables

Rapid determination of volatile composition from Polygala furcata Royle by MAE–HS-SPME followed by GC–MS

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