Fast cortical dynamics encode tactile grating orientation during active touch

Harrell, Evan R.; Renard, Anthony; Bathellier, Brice

doi:10.1126/sciadv.abf7096

Cited by 4 publications

(3 citation statements)

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“…Such experiments show that for the visual and somatosensory modalities, primary sensory cortex participates even to simple detection or discrimination behaviors [5,6,9,10]. However some somatosensory cortex lesion experiments show that performance can rapidly recover after the lesion [5], suggesting as in blindsight that primary sensory cortex is dispensable for simple (but not complex [11,12]) sensory behaviors. The same conclusion can be drawn in the auditory domain, as pretraining lesions also show that auditory cortex is dispensable for sound detection or simple discrimination [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Ces expériences montrent que pour les modalités visuelles et somatosensorielles, les cortex sensoriels primaires participent par défaut à des comportements simples de détection ou de discrimination [5,6,9,10]. Cependant, certaines expériences de lésion du cortex somatosensoriel montrent que les performances comportementales peuvent rapidement augmenter après la lésion [5], ce qui suggère, comme pour la vision aveugle, que le cortex sensoriel primaire n'est pas nécessaire pour les comportements sensoriels simples (mais il est nécessaire pour les comportements complexes [11,12]). La même conclusion peut être tirée dans le domaine auditif, puisque les lésions avant entraînement montrent également que le cortex auditif n'est pas nécessaire pour la détection des sons ou les discriminations simples [13,14].…”

Section: Introductionunclassified

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Differential roles of auditory and visual cortex for sensory detection in mice

Ceballo¹,

Deneux²,

Siliceo³

et al. 2022

Comptes Rendus. Biologies

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Sensory cortex encompasses the regions of the cerebral cortex that receive primary sensory inputs and is crucial for conscious sensory perception in humans. Yet, some forms of perception are possible without sensory cortex. For example in animal models, the association of a sound detection to a simple behavior resists to the inactivation of auditory cortex. In contrast, post-training inactivation experiments conducted in visual or somatosensory cortex led to much stronger effects. Here we show that muscimol inactivation of visual or auditory cortex in the same detection protocol transiently abolishes visual but not auditory detection. We also observe that cortex-dependency correlates with longer reaction times. This suggests that auditory cortex is more easily bypassed by other circuits for stimulus detection than other primary sensory areas, which may be due to timing differences between auditory and visual associations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionunclassified

Differential roles of auditory and visual cortex for sensory detection in mice

Ceballo¹,

Deneux²,

Siliceo³

et al. 2022

Comptes Rendus. Biologies

Self Cite

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“…Neuronal activity in the vibrissal primary somatosensory cortex (vS1) of mice successfully trained on a sensory task reflects not only sensory stimuli but also various types of behavior-related information 1,2 , including information about behavioral choice [3][4][5][6][7][8] . Insight into learning-related changes in cortical neuronal activity is key to understanding how the brain enables flexible behavior.…”

Section: Introductionmentioning

confidence: 99%

Stimulus information guides the emergence of behavior related signals in primary somatosensory cortex during learning

Panniello

Gillon

Maffulli

et al. 2022

Preprint

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Cortical neurons in primary sensory cortex carry not only sensory but also behavior-related information. However, it remains unclear how these types of information emerge and are integrated with one another over learning and what the relative contribution of activity in individual cells versus neuronal populations is in this process. Current evidence supports two opposing views of learning-related changes: 1) sensory information increases in primary cortex or 2) sensory information remains stable in primary cortex but its readout efficiency in association cortices increases. Here, we investigate these questions in primary sensory cortex during learning of a sensory task. Over the course of weeks, we imaged neuronal activity at different depths within layers 2 and 3 of the mouse vibrissal primary somatosensory cortex (vS1) before, during, and after training on a whisker-based object-localization task. We leveraged information theoretical analysis to quantify stimulus and behavior-related information in vS1 and estimate how much neural activity encoding sensory information is used to inform perceptual choices as sensory learning progresses. We also quantified the extent to which these types of information are supported by an individual neuron or population code. We found that, while sensory information rises progressively from the start of training, choice information is only present in the final stages of learning and is increasingly supported by a population code. Moreover, we demonstrate that not only the increase in available information, but also a more efficient readout of such information in primary sensory cortex mediate sensory learning. Together, our results highlight the importance of primary cortical neurons in perceptual learning.

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