Fast Continuous Non-Seeded Cooling Crystallization of Glycine in Slug Flow: Pure α-Form Crystals with Narrow Size Distribution

Mou, Mingyao; Jiang, Mo

doi:10.1007/s12247-020-09438-0

Cited by 21 publications

(19 citation statements)

References 51 publications

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“…The CSD obtained from bulk crystallization was always broader compared to emulsion crystallization, which was reflected by the higher CV and was consistent with a lack of confinement or possibly enhanced secondary nucleation. ,− Therefore, the trends in the crystal number density and the CSD from this study suggested that primary nucleation was likely dominant in emulsion solution crystallization, which made the crystallization behavior more stochastic for individual droplets and more sensitive to supersaturation. The latter may explain why relatively small differences in the cooling profile could still cause substantial differences in the crystal number density.…”

Section: Resultssupporting

confidence: 66%

Impact of Cooling Profile on Batch Emulsion Solution Crystallization

Kwon

Lakerveld

2022

Ind. Eng. Chem. Res.

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Emulsion solution crystallization can achieve a narrow and predictable crystal size distribution (CSD) when the emulsion droplets are uniform. The crystallization kinetics of emulsion solution crystallization are generally different from those of conventional bulk crystallization. This work characterizes the impact of temperature profile on emulsion solution cooling crystallization. The temperature is controlled by a tubular heat exchanger, and a membrane is used to create an emulsion with controllable droplet size distribution. The crystallization performance is characterized by the dynamic development of the crystal number density and the CSD, which are compared with those of bulk cooling crystallization. The crystal number density is highly sensitive to the cooling profile, and the process behavior is consistent with a system dominated by primary nucleation. Regardless of the cooling profile, secondary nucleation is suppressed in the emulsion with confined crystallization inside the droplets, which results in a narrow CSD. In contrast, secondary nucleation is dominant in bulk crystallization, leading to a broader CSD with a higher crystal number density. The mean crystal length decreases as the batch time increases with emulsion crystallization, which is different from bulk crystallization. A more predictable and narrower CSD can be obtained from emulsion crystallization, but a higher supersaturation or longer batch time is needed in emulsion crystallization to achieve a similar yield when compared to that in conventional bulk cooling crystallization.

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Section: Resultssupporting

confidence: 66%

Impact of Cooling Profile on Batch Emulsion Solution Crystallization

Kwon

Lakerveld

2022

Ind. Eng. Chem. Res.

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“…Some authors have reported that nucleation occurs under conditions in which it is not typically observed. (Ferguson et al, 2013;Mou and Jiang, 2020). e promoted nucleation rate and higher growth rate observed in the segmented ow crystallization can be attributed to the higher shear rate.…”

Section: Comparison Between Segmented Ow and Ow In Stirred Vesselmentioning

confidence: 92%

Effect of Fluid Flow on Crystallization in a Segmented Flow Microchannel

Yamasaki

Sotowa

Horikawa

2021

J. Chem. Eng. Japan

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“…Batch-mode stirred tank reactors also suffer from intrinsic batch-to-batch variability and difficulty in scale-up, can cause particle breakage due to high shear, and require high energy/time. [49][50][51][52] The issues become much worse for particles with complex structures. Recently continuous-mode stirred tanks were shown to improve particle uniformity, although the problem is not entirely solved.…”

Section: Co-precipitationmentioning

confidence: 99%