“…Additional practical challenges may occur from difficulties in the synthesis of those best reagent structures predicted from computations. Thus, combinatorial synthetic approaches have been applied for the development of new fluorescent − and colorimetric − reagents. Recent reviews are available on the fluorescent labels and probes. , Recent developments resulted in the discovery of a wide variety of new useful reagents for the detection of metal ions, ,,, ATP, GTP, dipeptides, tripeptides, and reagents that selectively bind to amyloid 332 and different cell components. , …”