“…Moreover, the levels of the antioxidant molecule, glutathione, and the activity of the antioxidant enzymes, superoxide dismutase, were elevated as compared to doxorubicin treatment alone. These findings confirmed the antioxidant potential of OA extract in MCF-7 cells that could be attributed to the presence of major flavonoids such as kaempferol, quercetin, isorhamnetin and luteolin (Barakat et al, 1991, Cristea et al, 2003, Moiteiro et al, 2008, Marques et al, 2009, Berrehal et al, 2010, Villela et al, 2011). The majority of natural antioxidants are polyphenols including flavonoids, which exhibit strong antioxidant activity by acting as free radical scavengers, hydrogen donors, singlet oxygen quenchers, and metal ion chelators, in addition to inducing gene expressions of antioxidant enzymes (Krinsky, 1992, Rice-Evans, 2001).…”