Fast and sensitive trace analysis of malachite green using a surface-enhanced Raman microfluidic sensor

Lee, Sangyeop; Choi, Jung‐Hyun; Chen, Lingxin; Park, Byungchoon; Kyong, Jin Burm; Seong, Gi Hun; Choo, Jaebum; Lee, Yeonjung; Shin, Kyung‐Hoon; Lee, Eun Kyu; Joo, Sang‐Woo; Lee, Kyeong-Hee

doi:10.1016/j.aca.2007.03.049

Cited by 150 publications

(103 citation statements)

References 18 publications

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“…35,37 The other is called heterogeneous SERS, for which the target in solution interacts with patterned metallic structure on the substrate. 20,23,[37][38][39][40] When detecting low concentration of analytes, the heterogeneous SERS method is usually adopted owing to its better sensitivity. However, diffusion of analytes to the SERS active site is time-consuming and fabrication of substrate with uniform SERS effect is relatively complicated.…”

Section: Introductionmentioning

confidence: 99%

Electrokinetic trapping and surface enhanced Raman scattering detection of biomolecules using optofluidic device integrated with a microneedles array

Deng

Juang

2013

Biomicrofluidics

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In this study, microneedles which possess sharp tips were utilized to trap and detect the biomolecules. Owing to the large curvature, the tips of the microneedles created a substantially high gradient of electric field under the non-uniform electric field which served as not only the trapping sites but also the substrate for surface enhanced Raman scattering (SERS). Separation of polystyrene microparticles with different sizes and two kinds of biomolecules (Staphylococcus aureus (S. aureus) and the red blood cells (RBCs)) were demonstrated. Moreover, in situ detection of S. aureus was performed immediately after separation was completed. The results showed that, after 15 s of sample collection, the Raman signals of S. aureus were detected and greatly enhanced through SERS effect. V C 2013 American Institute of Physics. [http://dx

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Section: Introductionmentioning

confidence: 99%

Electrokinetic trapping and surface enhanced Raman scattering detection of biomolecules using optofluidic device integrated with a microneedles array

Deng

Juang

2013

Biomicrofluidics

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“…Since the discovery of the SERS effect in the 1970s [16][17][18], SERS has been applied to a wide variety of biomedical and environmental analytical applications at the level of molecules, pathogens, cells, and even whole living animals [19][20][21][22]. The enhancement associated with SERSup to 10 14 times [23]-is widely attributed to two primary mechanisms: the short-range chemical effect and the longrange classical electromagnetic effect.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

et al. 2011

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A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N=3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices.

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“…36 As a fungicide and preservative, MG has been widely used in industry. However, because its genotoxic and carcinogenic effects, MG was classied under category C.III by FAO/WHO.…”

Section: 35mentioning

confidence: 99%

Brushing, a simple way to fabricate SERS active paper substrates

Zhang

Chen

et al. 2014

Anal. Methods

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A simple and facile method has been demonstrated to fabricate low-cost surface enhanced Raman scattering (SERS) active microfluidic paper chips using a painting brush. This strategy solves the problem of mass production of highly reproducible SERS substrates without complicated or bulky micro-or nanofabrication instruments. Rhodamine 6G (R6G) was chosen as a probe molecule to evaluate the performance of the SERS active chip. To further demonstrate the possibility of this method's potential application in environmental monitoring, trace malachite green (MG) was successfully analyzed on this chip. The performance of our chips was desirable. The paper substrates with silver nanoparticles deposited by brush were found to be cost-efficient and highly sensitive (LOD for R6G and MG are 1 nM and 10 nM, respectively), and have good reproducibility ($15% relative standard deviation).

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Fast and sensitive trace analysis of malachite green using a surface-enhanced Raman microfluidic sensor

Cited by 150 publications

References 18 publications

Electrokinetic trapping and surface enhanced Raman scattering detection of biomolecules using optofluidic device integrated with a microneedles array

Electrokinetic trapping and surface enhanced Raman scattering detection of biomolecules using optofluidic device integrated with a microneedles array

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

Brushing, a simple way to fabricate SERS active paper substrates

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