Fast and Furious: Fast Neutron Therapy in Cancer Treatment

Гордон, Константин; Гулидов, И. А.; Fatkhudinov, Timur; Koryakin, Sergey; Каприн, А. Д.

doi:10.14338/ijpt-22-00017

Cited by 13 publications

(6 citation statements)

References 89 publications

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“…In addition, improvements in conventional photon conformity and the shielding requirements of neutrons (among others) lead to NRT's near abandonment. This is despite improvements in beam profile safety that may make neutron delivery more practical for treatment 468,469 …”

Section: Radiation Modalities For Treatment Of Sinonasal Malignanciesmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Section: Radiation Modalities For Treatment Of Sinonasal Malignanciesmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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“…Fast neutrons are the production of one of the nuclear reactions such as fusion interaction (d + T or d + D), stripping reactions (d + Be), and inelastic interactions (p + Be). Among all these nuclear reactions, p + Be is the most preferable option for modern, high-energy facilities [121].…”

Section: Fast Neutron Therapymentioning

confidence: 99%

Advances in Radiotherapy Dosimetry Techniques and Pre-Treatment Verification

Salari,

Ishmael Parsai

2023

Advances in Dosimetry and New Trends in Radiopharmaceuticals

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In the fight against cancer, radiation therapy plays a vital role, with its two essential approaches: internal, involving the insertion or implantation of radioactive material into the patient’s body, or uptake of radiopharmaceutical, and external. Precise delivery of the appropriate radiation dosage to the tumor is critical for achieving favorable outcomes. This is where dosimetry becomes crucial—a scientific discipline that involves measuring, calculating, and evaluating radiation doses. Medical physicists utilize dosimetry to ensure the accuracy and proper calibration of machines that administer ionizing radiation, ensuring safety. This chapter provides a brief overview of advanced techniques and equipment used in dosimetry, with a primary focus on photon and electron dosimetry, the most widely employed forms of radiation for radiotherapy worldwide.

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“…На основании полученных результатов мы сделали предположительные выводы: в связи с тем, что бóльшая часть рецидивов локализуется в поле облучения в пределах 95 % изодозы, то очевидно, что повторное стандартное облучение не всегда эффективно, что и объясняет полученные нами и имеющиеся на сегодняшний день данные, отмечающие наилучшие результаты лечения у больных, прошедших повторный курс лучевой терапии с применением современных технологий, обеспечивающих точное подведение высоких доз к ограниченной мишени, таких как стереотаксическая лучевая терапия [16,17] и применение излучений с большей биологической эффективностью в сравнении с фотонным излучением -протонной и нейтронной [18][19][20].…”

Section: результаты и обсуждениеunclassified

Results of Treatment of Patients with Progression of Primary Highly Malignant Brain Gliomas During a Repeated Course of Radiation Therapy. Own Experience

Sarycheva,

Vazhenin,

Sukhanov

et al. 2023

jour

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Purpose: To determine the most effective option for repeated radiation therapy in patients with continued growth of primary high-grade brain glioma, taking into account the isodose distribution during the initial course of radiation therapy. Material and methods: As a result of a retrospective analysis, the results of treatment of 100 patients with confirmed progression of high-grade glioma treated at the Chelyabinsk Regional Center for Oncology and Nuclear Medicine in the period from 2010 to 2020 were evaluated. The ratio of men and women was approximately equal (56 men and 44 women). The mean age of patients of both sexes was 47.2±11.9 years. According to the histological conclusion, patients with glioblastomas (GB) prevailed (n = 58), 42 patients were diagnosed with anaplastic astrocytoma (AA). Reoperation was performed in 26 patients. Repeated radiation therapy in an independent variant was performed in 76 patients of them: 17 patients received a course of neuronal therapy in mono mode and in 17 patients in combination with external beam radiation therapy; 23 patients underwent stereotactic radiotherapy (SRS) using the CyberKnife device; in 19 cases, remote radiation therapy. In 24 cases, a chemotherapeutic component was added in addition to radiation treatment. Results: Mean time to relapse was 23 months. The median overall survival (OS) for all patients was 35 months. (DI 26.2–43.7). Indicators of 1-year OS — 85.6 %; 3-year-old — 44.1 %, 5-year-old — 26.5 %. Depending on the type of radiation therapy: the highest progression-free survival (PFS) was found with SPLT and combined photon-neutron therapy (SPNT) as in the group of patients with recurrent EH for 15, 17, and AA 24 and 40 months, respectively. Among the patients included in our study, the majority of patients (42 people) had central recurrences (in which 95 % or more of the volume of the recurrent tumor was within 100-95 % of the initial isodose), 6 had marginal relapses (20 to 80 % of the recurrent volume is within the surface of 95 % isodose), and in 2 cases a distant recurrence was recorded (less than 20 % of the recurrent volume was within 95 % of the isodose). Distant recurrences (marginal and distant) occurred within an average of 12 months, while central recurrences were diagnosed on average 26 months after the end of the course of radiation (chemoradiation) treatment. Conclusion: Thus, when analyzing our data, in all patients with continued growth of primary high-grade brain gliomas, the method of choice for a repeated course of radiation therapy is stereotactic radiation therapy or a combined course of photon-neutron therapy, which allows to overcome the existing radioresistance.

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Fast and Furious: Fast Neutron Therapy in Cancer Treatment

Cited by 13 publications

References 89 publications

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Advances in Radiotherapy Dosimetry Techniques and Pre-Treatment Verification

Results of Treatment of Patients with Progression of Primary Highly Malignant Brain Gliomas During a Repeated Course of Radiation Therapy. Own Experience

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