Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus

Nakaminami, Hidemasa; Takadama, Shunsuke; Okita, Mitsuaki; Sasaki, Mari; Noguchi, Norihisa

doi:10.1099/jmm.0.000979

Cited by 12 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are three types of multidrugpumping proteins present on the Staphylococcus aureus cell membrane: QacA, NorA, and Smr (Foster, 2016;Jang, 2016). Noguchi et al considered QacA to be an important factor in MRSA (Noguchi et al, 2005;Nakaminami et al, 2019). Multidrug pumping proteins are all proton kinesins (Foster, 2016).…”

Section: Efflux Systemsmentioning

confidence: 99%

Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus

Guo

Song

Sun

et al. 2020

Front. Cell. Infect. Microbiol.

529

350

View full text Add to dashboard Cite

Infectious diseases are the second most important cause of human death worldwide; Staphylococcus aureus (S. aureus) is a very common human pathogenic microorganism that can trigger a variety of infectious diseases, such as skin and soft tissue infections, endocarditis, osteomyelitis, bacteremia, and lethal pneumonia. Moreover, according to the sensitivity to antibiotic drugs, S. aureus can be divided into methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). In recent decades, due to the evolution of bacteria and the abuse of antibiotics, the drug resistance of S. aureus has gradually increased, the infection rate of MRSA has increased worldwide, and the clinical anti-infective treatment for MRSA has become more difficult. Accumulating evidence has demonstrated that the resistance mechanisms of S. aureus are very complex, especially for MRSA, which is resistant to many kinds of antibiotics. Therefore, understanding the drug resistance of MRSA in a timely manner and elucidating its drug resistance mechanism at the molecular level are of great significance for the treatment of S. aureus infection. A large number of researchers believe that analyzing the molecular characteristics of S. aureus can help provide a basis for designing effective prevention and treatment measures against hospital infections caused by S. aureus and further monitor the evolution of S. aureus. This paper reviews the research status of MSSA and MRSA, the detailed mechanisms of the intrinsic antibiotic resistance and the acquired antibiotic resistance, the advanced research on anti-MRSA antibiotics and novel therapeutic strategies for MRSA treatment.

show abstract

Section: Efflux Systemsmentioning

confidence: 99%

Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus

Guo

Song

Sun

et al. 2020

Front. Cell. Infect. Microbiol.

529

350

View full text Add to dashboard Cite

show abstract

“…Nine studies validated the spectrum: seven for bacteria and fungi 20 , 21 , 22 , 23 , 24 , 25 , 28 and four for viruses. 28 , 32 , 33 , 34 Several studies 20 , 23 , 25 , 28 used the minimum bactericidal concentration (MBC) at which bacterial growth did not occur as an indicator of the bactericidal effect of skin disinfectants.…”

Section: Resultsmentioning

confidence: 99%

“…For MRSA, two studies showed that 1.5% OLG was more effective for disinfection than 0.5% CHG and 10% PVP‐I (Table 3 ). 22 , 25 In addition, two studies 20 , 24 compared whether the MBC of OLG, CHG, and PVP‐I changed in the presence or absence of qacA/B , which encodes a disinfectant efflux pump thought to be responsible for methicillin resistance. The researchers reported that only the MBC of OLG remained unchanged in the presence or absence of qacA/B (Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies were identified: three on the time‐to‐onset of bactericidal action 20 , 21 , 22 and two on the duration of bactericidal action. 22 , 36 …”

Section: Resultsmentioning

confidence: 99%

“…In vitro, OLG has a broad‐spectrum, disinfecting, and fast‐acting activity against drug‐resistant bacteria. 20 , 21 , 22 , 23 , 24 , 25 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical application of skin antisepsis using aqueous olanexidine: a scoping review

Shinzato

Sakihara

Kishihara

et al. 2022

Acute Medicine & Surgery

View full text Add to dashboard Cite

Surgical site infections (SSIs) and catheter‐related bloodstream infections (CRBSIs) caused by bacteria from surfaces poorly disinfected with chlorhexidine gluconate (CHG) and povidone‐iodine (PVP‐I) are increasing. Olanexidine gluconate (OLG) was developed in 2015 in Japan to prevent SSI and CRBSI caused by bacteria resistant to CHG and PVP‐I. This scoping review aimed to identify the knowledge gap between what is known and what is not known about the disinfection efficacy of OLG. We searched MEDLINE through PubMed, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the International Clinical Trials Registry Platform search database, ClinicalTrials.gov , and the Web‐based database of Japanese medical articles for works published to July 18, 2021. Manual reference searches were also carried out. A total of 131 studies were screened. Forty‐seven studies were included in this review and classified into two major categories: studies on pharmacological effects and spectrum ( n = 29) and studies on clinical and adverse effects ( n = 18). Olanexidine gluconate showed bactericidal activity against methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci, in addition to common Gram‐positive and Gram‐negative bacteria. In clinical settings, although there is limited evidence on SSI prevention, 1.5% OLG might be more effective than 10% PVP‐I and 1% CHG in preventing SSI. However, the clinical usefulness of OLG is unclear due to the limited number of clinical studies. Also, clinical research is limited to studies targeting SSI prevention, and there are no clinical studies on CRBSI. Further clinical studies are needed on SSI and CRBSI prevention.

show abstract