Fast, accurate and easy-to-teach QT interval assessment: The triplicate concatenation method

Abstract

Conflicts of interest: None Abstract (English -250 words)Background: The gold standard method for assessing QTcF interval is the "QTcF semi-

A Randomized, Double‐Blind, Placebo‐ and Positive‐Controlled, 4‐Period Crossover Study of the Effects of Solriamfetol on QTcF Intervals in Healthy Participants

“…A single reader from the central cardiac laboratory (Celerion, Tempe, Arizona) was used for the review of ECGs from a particular participant. The ECG recordings were measured and classified by software from AMPS, LLC, New York City, New York; all extracted ECG recordings were automatically measured by CalECG 15–18 . The quality of the ECG recordings was assessed, and those meeting the quality criteria thresholds were recorded in the database without cardiologist review.…”

“…The ECG recordings were measured and classified by software from AMPS, LLC, New York City, New York; all extracted ECG recordings were automatically measured by CalECG. [15][16][17][18] The quality of the ECG recordings was assessed, and those meeting the quality criteria thresholds were recorded in the database without cardiologist review. All ECG recordings not meeting specific quality criteria thresholds and all waveforms identified for review by the automated algorithm were reviewed by a single board-certified cardiologist who was blinded to subject, time, and treatment.…”

Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women

“…7 The inhibition of IKr is associated with QTc prolongation and the appearance of notches ( Figure 1). 7 We used the Fridericia correction 9,10 (QT/ 3 ͙RR, in which QT is the time from the start of the Q wave to the end of the T wave and RR is defined as the time from the onset of 1 QRS complex to the start of the next). Further details of the parent protocol are provided in the eAppendix in the Supplement.…”

Deep learning analysis of drug-induced ECG changes to inform arrhythmia risk and improve diagnosis of congenital long QT syndrome

“…For all ECG recorded in the Generopol cohort, the QTc values, i.e. heart-rate corrected QT using the Fridericia formula 5 were measured by expert technicians and controlled by expert cardiologists (Cardiabase, Banook group, Nancy, France). The method consisted in measuring three consecutive QT values with a tangent-based approach mainly on lead LII.…”

“…3 These conditions have in common abnormalities of the QT interval, an electrocardiographic parameter which represents ventricular repolarization and is measured as the time lapsed between the beginning of the QRS complex and the end of the T-wave of the electrocardiogram (ECG). 4 Hence, the current risk stratification strategies for TdP are based on the quantification of the QT interval corrected for heart rate (QTc) 5 . Beyond QT duration, the morphology of the QT can also have a characetristic appearance in the three main forms of cLQT.…”