Fashionable, but What is Their Real Clinical Usefulness? NLR, LMR, and PLR as a Promising Indicator in Colorectal Cancer Prognosis: A Systematic Review

Misiewicz, Aleksandra; Dymicka-Piekarska, Violetta

doi:10.2147/jir.s391932

Cited by 30 publications

(23 citation statements)

References 89 publications

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“…[ 11 ] Inflammation plays a role in tumor invasion, angiogenesis, cell proliferation, and immune cell suppression. [ 13 ] Various cells such as neutrophils, lymphocytes, monocytes, and platelets play a role in the systemic inflammatory process,[ 33 ] and many studies have reported quantification of these cells as outcome indicators in patients with tumors.…”

Section: Discussionmentioning

confidence: 99%

The role of preoperative hematological inflammatory markers as a predictor of meningioma grade: A systematic review and meta-analysis

Rusidi,

Rosyidi,

Wardhana

et al. 2024

Surgical Neurology International

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Background: Inflammatory processes play an important role in the aggressiveness of a tumor. However, the relationship between inflammatory markers in meningioma grade is not well known. Knowledge of preoperative meningioma grade plays an important role in the prognosis and treatment of this tumor. This study aims to assess preoperative hematological inflammatory markers as a predictor of the pathological grade of meningioma. Methods: To ensure comprehensive retrieval of relevant studies, we searched the following key databases, PubMed, Science Direct, and Biomed Central, with evidence related to preoperative hematological inflammatory markers among meningioma up to September 2023. The studies involved were selected based on established eligibility criteria. The analysis in this study uses Review Manager 5.4 Results: Six studies were obtained from the search results. The total number of patients 2789 (469 high-grade meningioma and 2320 low-grade meningioma) analysis shows elevated neutrophil-to-lymphocyte ratio (NLR) (mean difference [MD]: 0.29; 95% confidence interval [CI] 0.13–0.45; P = 0.0004), monocyte-to-lymphocyte ratio (MLR) (MD: 0.02; 95% CI 0.00–0.04; P = 0.003), and low lymphocyte-to-monocyte ratio (LMR) (MD: −0.82; 95% CI −1.46–−0.18; P = 0.005) significantly associated with high-grade meningioma compared to low-grade meningioma. No significant correlation between high-grade and low-grade meningioma based on platelet-lymphocyte ratio value is observed. Conclusion: The parameters of NLR, MLR, and LMR have been found to be cost-effective preoperative methods that demonstrate potential value in the prediction of meningioma grade. To enhance the reliability of the findings, it is imperative to do further prospective study.

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Section: Discussionmentioning

confidence: 99%

The role of preoperative hematological inflammatory markers as a predictor of meningioma grade: A systematic review and meta-analysis

Rusidi,

Rosyidi,

Wardhana

et al. 2024

Surgical Neurology International

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“…Numerous studies have demonstrated the signi cant involvement of in ammation in tumor initiation and progression. Several recent studies have shown that systemic in ammatory response markers, including CRP 15 , glasgow prognostic score 16 , PLR 17 , LMR 18 , are associated with CRC and poor survival in many other cancers 19 . In particular, NLR, which is considered one of the markers of systemic in ammatory response, is closely related to the prognosis of patients with various types of cancer 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Nomogram Based on Inflammatory indicators and Tumor Markers for Prognosis Prediction of Colorectal Cancer

Shi

Guo

Chen³

et al. 2023

Preprint

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Background: Reliable evaluation methods play an important role in improving the prognosis of colorectal cancer patients, guiding the development of treatment plans, and prolonging patient survival. Several preoperative inflammatory indicators and tumor markers were evaluated in this study for predicting colorectal cancer (CRC) prognosis. Methods: A total of 224 eligible patients with CRC were enrolled in the present study. Patients were divided into a training group (n=150) and a validation group (n=74). The training cohort underwent both the least absolute shrinkage and selection operator (LASSO) regression and Cox regression analyses to discern pivotal prognostic factors, aiming to formulate a nomogram for the prediction of overall survival (OS). Results: LASSO regression, univariate and multivariate Cox regression analysis revealed that Neutrophil-lymphocyte ratio (NLR), carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were effective risk factors. The concordance index (C-index) of the nomogram in the training and validation groups were 0.716 and 0.7 respectively. The areas under curve (AUC) of the nomogram for 3-years were 0.748 and 0.776, for 5-years were 0.749 and 0.773 respectively. Conclusion: NLR, CA199 and CEA were effective supplements to traditional clinical assessment methods. The nomogram incorporating the three preoperative indicators can be effectively and efficiently used to predict the prognosis of CRC patients.

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“…Of note, several composite inflammatory indicators, including but not limited to systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have been validated to be feasible in predicting the prognosis of various cancers and inflammatory diseases ( 16 – 19 ). These composite indicators, comprising biomarkers easily available in clinical settings such as peripheral lymphocytes, platelets, neutrophils, and monocytes, offer a comprehensive reflection of both local immune status and systemic inflammation condition ( 20 – 23 ). Whether these newly developed indicators presented equivalent predictive value in CKD has not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

Association between systemic inflammatory indicators with the survival of chronic kidney disease: a prospective study based on NHANES

Chen,

Nie,

et al. 2024

Front. Immunol.

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Backgroundsystemic inflammation disorders were observed in chronic kidney disease (CKD). Whether the systemic inflammatory indicators could be optimal predictors for the survival of CKD remains less studied.MethodsIn this study, participants were selected from the datasets of the National Health and Nutrition Examination Survey (NHANES) between 1999 to 2018 years. Four systemic inflammatory indicators were evaluated by the peripheral blood tests including systemic immune-inflammation index (SII, platelet*neutrophil/lymphocyte), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR). Kaplan-Meier curves, restricted cubic spline (RCS), and Cox regression analysis were used to evaluate the association between the inflammatory index with the all-cause mortality of CKD. Receiver operating characteristic (ROC) and concordance index (C-index) were used to determine the predictive accuracy of varied systemic inflammatory indicators. Sensitive analyses were conducted to validate the robustness of the main findings.ResultsA total of 6,880 participants were included in this study. The mean age was 67.03 years old. Among the study population, the mean levels of systemic inflammatory indicators were 588.35 in SII, 2.45 in NLR, 133.85 in PLR, and 3.76 in LMR, respectively. The systemic inflammatory indicators of SII, NLR, and PLR were all significantly positively associated with the all-cause mortality of CKD patients, whereas the high value of LMR played a protectable role in CKD patients. NLR and LMR were the leading predictors in the survival of CKD patients [Hazard ratio (HR) =1.21, 95% confidence interval (CI): 1.07-1.36, p = 0.003 (3rd quartile), HR = 1.52, 95%CI: 1.35-1.72, p<0.001 (4th quartile) in NLR, and HR = 0.83, 95%CI: 0.75-0.92, p<0.001 (2nd quartile), HR = 0.73, 95%CI: 0.65-0.82, p<0.001 (3rd quartile), and = 0.74, 95%CI: 0.65-0.83, p<0.001 (4th quartile) in LMR], with a C-index of 0.612 and 0.624, respectively. The RCS curves showed non-linearity between systemic inflammatory indicators and all-cause mortality risk of the CKD population.ConclusionOur study highlights that systemic inflammatory indicators are important for predicting the survival of the U.S. population with CKD. The systemic inflammatory indicators would add additional clinical value to the health care of the CKD population.

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Fashionable, but What is Their Real Clinical Usefulness? NLR, LMR, and PLR as a Promising Indicator in Colorectal Cancer Prognosis: A Systematic Review

Cited by 30 publications

References 89 publications

The role of preoperative hematological inflammatory markers as a predictor of meningioma grade: A systematic review and meta-analysis

The role of preoperative hematological inflammatory markers as a predictor of meningioma grade: A systematic review and meta-analysis

Development and Validation of a Nomogram Based on Inflammatory indicators and Tumor Markers for Prognosis Prediction of Colorectal Cancer

Association between systemic inflammatory indicators with the survival of chronic kidney disease: a prospective study based on NHANES

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