Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle

Claridge, J.; Diggle, Peter J.; McCann, Catherine M.; Mulcahy, Grace; Flynn, Robin J.; McNair, J.; Strain, Sam; Welsh, Michael; Baylis, Matthew; Williams, Diana

doi:10.1038/ncomms1840

Cited by 127 publications

(155 citation statements)

References 27 publications

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“…There are better public health or indeed animal health deals that could be achieved with the £100 million or more that is being 430 435 440 445 spent by the UK government. Ironically it takes a publication that demonstrates that concurrent infection with F. hepatica may reduce the diagnostic efficiency of the bovine tuberculosis test (Claridge et al, 2012) for bovine fasciolosis, an arguably more important animal disease, to be noticed! In low income countries the situation is different.…”

Section: Bovine Tuberculosismentioning

confidence: 99%

One world health: Socioeconomic burden and parasitic disease control priorities

Torgerson¹

2013

Veterinary Parasitology

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Parasitic diseases present a considerable socio-economic impact to society. Zoonotic parasites can result in a considerable burden of disease in humans and substantive economic losses to livestock populations. Ameliorating the effects of these diseases may consist of attempts at eradicating specific diseases at a global level, eliminating them at a national or local level or controlling the disease to minimise incidence. Alternatively with some parasitic zoonoses it may only be possible to treat human and animal cases as they arise. The choice of approach will be determined by the potential effectiveness of a disease control programme, its cost and the cost effectiveness or cost benefit of undertaking the intervention. Furthermore human disease burden is being increasingly measured by egalitarian nonfinancial measures which do not sit comfortably with measurements of economic costs in livestock.This adds additional challenges to assessing socio-economic burdens of zoonotic diseases. Using examples from the group of neglected zoonotic diseases, information regarding the socio-economic effects of these diseases are reviewed and the use of this information in decision making with regard to control and treatment of these diseases is discussed.

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Section: Bovine Tuberculosismentioning

confidence: 99%

One world health: Socioeconomic burden and parasitic disease control priorities

Torgerson¹

2013

Veterinary Parasitology

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“…Fasciola hepatica, a parasitic flatworm also known as the common liver fluke, can suppress protective Th1-driven immunity against bystander infections such as tuberculosis and Bordetella pertussis infection (17)(18)(19). It can also attenuate experimental autoimmune encephalomyelitis (EAE) through the suppression of Th17 and Th1 immune responses (20).…”

Section: Ast Cells Are Associated With Helminth Infection Butmentioning

confidence: 99%

Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

Vukman

Adams

Metz

et al. 2013

The Journal of Immunology

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The parasitic worm Fasciola hepatica induces strong Th2 and T-regulatory immune responses while simultaneously suppressing Th1-driven immune responses to bystander microbial infections. It also prevents the initiation of Th1-mediated autoimmune disorders in mice through the suppression of Th17 and Th1 immune responses, and this can be mimicked by parasite-derived molecules. We have isolated F. hepatica tegumental coat Ag (FhTeg) and demonstrated its suppressive effect in vivo by directly targeting dendritic cells, impairing their ability to drive Th1 responses. Mast cells are critical in promoting Th1 protective immunity during bacterial infection and in driving Th1-mediated pathological conditions in autoimmune diseases. In this article, we show that FhTeg inhibits the ability of mast cells to drive the Th1 immune response by suppressing cytokine secretion (TNF-α, IL-6, IFN-γ, and IL-10) and ICAM1 expression in mast cells stimulated with LPS or heat-inactivated Bordetella pertussis Ag. These heat-inactivated B. pertussis Ag/LPS–stimulated mast cells fail to promote Th1 immune responses in CD4+ T cells when pretreated with FhTeg, and a role for ICAM1 in this process was demonstrated. FhTeg suppresses the activation of transcription factors in the TLR signaling pathway, which explains the decrease in cytokine production and cell surface marker expression. We demonstrated that FhTeg suppresses MAPK and NF-κB activation and enhances SOCS3 expression, which could explain its negative effect on the TLR pathways. We conclude that FhTeg targets innate immune cells, inhibiting their ability to drive Th1 immune responses.

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“…Flooding might exacerbate environmental contamination of grazing pastures or drinking water with M. bovis and might also reduce badger food sources, forcing them to visit farm feed stores, so increasing contact between badgers and cattle (Garnett et al 2002). Additionally, areas prone to flooding may harbour the helminth Fasciola hepatica (liver fluke), and concurrent infection of cattle with this parasite may reduce the sensitivity of the tuberculin skin test (Flynn et al 2009;Ezenwa et al 2010;Claridge et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Using geographically weighted regression to explore the spatially heterogeneous spread of bovine tuberculosis in England and Wales

Brunton

Alexander

Wint

et al. 2016

Stoch Environ Res Risk Assess

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An understanding of the factors that affect the spread of endemic bovine tuberculosis (bTB) is critical for the development of measures to stop and reverse this spread. Analyses of spatial data need to account for the inherent spatial heterogeneity within the data, or else spatial autocorrelation can lead to an overestimate of the significance of variables. This study used three methods of analysis-least-squares linear regression with a spatial autocorrelation term, geographically weighted regression (GWR) and boosted regression tree (BRT) analysis-to identify the factors that influence the spread of endemic bTB at a local level in England and Wales. The linear regression and GWR methods demonstrated the importance of accounting for spatial differences in risk factors for bTB, and showed some consistency in the identification of certain factors related to flooding, disease history and the presence of multiple genotypes of bTB. This is the first attempt to explore the factors associated with the spread of endemic bTB in England and Wales using GWR. This technique improves on least-squares linear regression approaches by identifying regional differences in the factors associated with bTB spread. However, interpretation of these complex regional differences is difficult and the approach does not lend itself to predictive models which are likely to be of more value to policy makers. Methods such as BRT may be more suited to such a task. Here we have demonstrated that GWR and BRT can produce comparable outputs.

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Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle

Cited by 127 publications

References 27 publications

One world health: Socioeconomic burden and parasitic disease control priorities

One world health: Socioeconomic burden and parasitic disease control priorities

Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

Using geographically weighted regression to explore the spatially heterogeneous spread of bovine tuberculosis in England and Wales

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