Fasciola hepatica human infection

Acosta-Ferreira, W; Vercelli-Retta, Jorge; Falconi, Luis

doi:10.1007/bf00430249

Cited by 69 publications

(10 citation statements)

References 9 publications

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“…Stool examinations for eggs can be diagnostic but are usually negative because of a generally low concentration of adult flukes and irregular shedding of eggs [34]. The immature flukes that penetrate the liver are rarely seen in histologic sections, and a tissue diagnosis of fascioliasis is usually not possible [15,28]. …”

Section: Discussionmentioning

confidence: 99%

“…Toxocara was identified in 30% of the specimens and was suggested to be the causative organism for the series. Based upon the experience with autopsies in Uruguay, Vercelli-Retta et al [14,15] in a following letter to the editor cautioned that Fasciola hepatica may be involved in similar cases, if not actually some of those in the AFIP collection. The fungal disease basidiobolomycosis is an additional cause of eosinophilic granulomatous gastrointestinal (GI) abscesses [16-19].…”

Section: Introductionmentioning

confidence: 99%

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Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan

Hassan¹,

Majid²,

Rashid³

et al. 2013

BMC Infect Dis

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BackgroundDeep eosinophilic granulomatous abscesses, as distinguished from eosinophilic subcutaneous abscesses, are rare. Most reports are from the Far-East and India where the most commonly attributed cause is Toxocara. Sulaimaniyah in Northeastern Iraq has experienced an outbreak of eosinophilic granulomatous liver and gastrointestinal (GI) abscesses beginning in 2009. The purpose of this study was to determine the etiology and guide treatment.MethodsThe study was an ongoing investigation of patients having a histopathologic diagnosis of eosinophilic granulomatous abdominal abscesses in Sulaimaniyah hospitals from May 2009 to August 2012. Tissues were examined for organisms, and Enzyme Linked Immunoabsorbent Assays (ELISA) were performed for serum antibodies to Fasciola hepatica, Toxocara, and Echinococcus granulosus.ResultsFourteen patients had granulomatous inflammation surrounding a central necrotizing eosinophilic exudate identified in surgical pathology specimens from abdominal surgeries. Two children and four adults had abscesses that formed GI masses. These patients included a 39 year old male with oropharyngeal and transverse colon disease, and a 48 year old male with liver and GI abscesses. All sites demonstrated a Zygomycete fungus surrounded by eosinophilic Splendori-Hoeppli material consistent with basidiobolomycosis. Five of the six patients with fungal disease were treated by surgery and 4 to 7 months of itraconozol. One child died of intestinal perforation while receiving IV amphotericin B; two adults required additional surgery for recurrent GI obstruction. Eight patients had isolated liver abscesses with no organisms identified by histopathology: ELISA results for F. hepatica were positive for five, borderline for one, and negative for two patients. These eight patients were treated for fascioliasis by surgical resection of localized abscesses and albendazol. One patient serologically positive for F. Hepatica was found to have a common duct fluke two years after initial diagnosis. Serological testing for Toxocara and Echinococcus granulosus was negative in all 14 patients.ConclusionsBasidiobolomycosis and F. hepatica are implicated as the cause of abdominal eosinophilic granulomatous abscesses in 12 of 14 patients identified over a period of 40 months in northern Iraq. Treatment was complicated by chronic biliary tract disease in fascioliasis and perforation and recurrent intestinal obstruction with basidiobolomycosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan

Hassan¹,

Majid²,

Rashid³

et al. 2013

BMC Infect Dis

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“…Central necrosis with eggs and worm remnants may be present. Other parasites that can cause granulomatous hepatic inflammation include Fasciola hepatica, 46 which may cause calculi, cholangitis, obstructive jaundice, and a granulomatous hepatitis; Toxoplasma gondii 47,48 ; Capillaria hepatica, Ascaris, Strongyloides stercoralis…”

Section: Selected Examples Of Hepatic Parasitic Infections Featuring mentioning

confidence: 99%

Hepatic Granulomas: A Review With Emphasis on Infectious Causes

Lamps

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context Many diseases that cause granulomas or granulomatous inflammation involve the liver. Some of these disease processes are intrinsic hepatic diseases, whereas others are disseminated systemic diseases that involve the liver as well as other organs. Objective To review the evaluation of granulomas in the liver with an emphasis on infectious causes, as well as the use of special stains, serologic studies, and molecular diagnostic techniques. Pertinent noninfectious causes of hepatic granulomas that are in the differential diagnosis are also discussed. Data Sources Literature review and cases acquired during years of practice. Conclusions A wide variety of infectious and noninfectious entities cause hepatic granulomas.

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“…These findings suggest that with increased biliary pressure, there is an activation and proliferation of the biliary epithelium leading to a multilayered epithelium which ultimately allows for dilation of the bile duct. However, several studies have indicated that proline excretion from a parasite may result in hyperplasia of the bile duct epithelium (Isseroff et al, 1977;Acosta-Ferreira et al, 1979;Vacanti and Folkman, 1979). It is not known for certain that T. stelmioides plays a role in stimulating hyperplasia of bile duct cells, but the similar response of the hosts to the various parasites seen in earlier studies is striking.…”

Section: Periductal Connective Tissuementioning

confidence: 89%

“…Bile ductular proliferation is a prominent feature of many forms of liver disorders (Buyssens, 1965) including in clonorchiasis (Sun and Tung-Ma, 1973), and in fasciolasis (Acosta-Ferreira et al, 1979). In mammalian cholestasis, ductular proliferation may be a secondary cause of intrahepatic obstruction (Buyssens, 1965;Desmet, 1972).…”

Section: Periductal Connective Tissuementioning

confidence: 99%

Morphology of the bile ducts of the brook lamprey, Lampetra lamottenii (Le Sueur) before and during infection with the nematode, Truttaedacnitis stelmioides (Vessichelli, 1910) (Nematoda: Cucullanidae)

Eng

Youson

1992

Anat. Rec.

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Routine light microscopy and transmission and scanning electron microscopy were used to describe and compare the biliary tree of larval Lampetra lamottenii before and during infestation of the bile ducts with the nematode, Truttaedacnitis stelmioides. The most prominent changes to the biliary tree following infection by the parasite are the dilation of the bile ducts, alterations to their epithelial cells, and an increase in periductal fibrous tissue. In recently infected animals, the simple epithelium of dilated bile ducts often contains many mitotic figures. In long-term infestations, the epithelium is stratified or pseudostratified. Changes to the fine structure of the biliary epithelial cells include increase and/or dilation of the RER and SER, and increases in microfilaments, intermediate filaments, and microtubules. The abundance of dense bodies may reflect enhance reabsorption of biliary constituents, and their accumulation may ultimately result in cytolysis. There are increased mucous granules in the apical cytoplasm of biliary epithelial cells and an abundance of mucinous material within the bile duct lumen, and the basal lamina appears thickened. The changes to the liver of L. lamottenii following infection are discussed and compared to those reported in small mammals following bile duct ligation, in patients with extrahepatic biliary obstruction, and in parasitic infection of the biliary tree.

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Fasciola hepatica human infection

Cited by 69 publications

References 9 publications

Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan

Eosinophilic granulomatous gastrointestinal and hepatic abscesses attributable to basidiobolomycosis and fasciolias: a simultaneous emergence in Iraqi Kurdistan

Hepatic Granulomas: A Review With Emphasis on Infectious Causes

Morphology of the bile ducts of the brook lamprey, Lampetra lamottenii (Le Sueur) before and during infection with the nematode, Truttaedacnitis stelmioides (Vessichelli, 1910) (Nematoda: Cucullanidae)

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