Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease

Binnetoğlu, Adem; Sarı, Murat; Bağlam, Tekin; Seven, İpek Erbarut; Yumuşakhuylu, Ali Cemal; Topuz, Muhammet Fatih; Batman, Caglar

doi:10.1111/coa.12373

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…In the staining scoring, epithelial and stromal staining rates were evaluated separately, and a semi-quantitative scoring system ranging from 0 to 3 for epithelia and from 0 to 4 for stroma was used. In the epithelial staining scoring [9], 0 represented no staining, 1 focal staining (+), 2 moderate staining (++) and 3 strong staining (+++). In the stromal staining scoring [10], 0 represented no staining, 1 focal staining (+), 2 diffuse staining in 1/2 area (++), 3 diffuse staining in more than 1/2 area (+++) and 4 diffuse staining (++++).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of periostin, fibronectin and tenascin-C in patients chronic otitis media with cholesteatoma

Birinci

Terzi

Demir

et al. 2022

Egypt J Otolaryngol

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Background Although many studies have investigated the mechanisms of cholesteatoma formation, its pathogenesis remains unclear. The aim of this study was to evaluate the levels of periostin, fibronectin and tenascin-C, which are involved in many mechanisms, such as cell adhesion, cell differentiation, inflammation, fibrosis, angiogenesis and cell proliferation, in patients with chronic otitis media (COM). A total of 80 participants, 65 COM patients undergoing surgery and 15 healthcare personnel volunteers serving as controls, were included in this study. The participants were divided into four groups: cholesteatoma, granulation, avivation and control group. The serum periostin, fibronectin and tenascin-C levels of all participants were determined biochemically. Histopathological evaluation of tissue samples and 20 skin samples used as controls was performed by immunohistochemistry. Results Of the 65 patients, 22 presented with cholesteatoma, 15 with granulation tissue and 28 with the edge of the tympanic membrane perforation freshening tissue. There were no significant differences in serum periostin, fibronectin and tenascin-C levels between the groups. In the immunohistochemical evaluation, fibronectin and periostin staining was significantly more intense in the cholesteatoma group than in the other groups (p = 0.001). Epithelial tenascin-C staining was significantly more intense in the avivation group than in the other groups (p = 0.041). Conclusion The levels of periostin and fibronectin were higher in cholesteatoma tissue than in other forms of chronic otitis and skin tissue. This suggests that they may be involved in the mechanism of cholesteatoma formation. These proteins could be used as biomarkers in the diagnosis and treatment of cholesteatoma.

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Section: Methodsmentioning

confidence: 99%

Evaluation of periostin, fibronectin and tenascin-C in patients chronic otitis media with cholesteatoma

Birinci

Terzi

Demir

et al. 2022

Egypt J Otolaryngol

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The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma

Xie

Wang

Ren

et al. 2016

Eur Arch Otorhinolaryngol

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Cholesteatoma is a destructive squamous epithelial lesion of the temporal bone which gradually expands and leads to serious complications by destruction of nearby bony structures. Erosion caused by bone resorption of the ossicular chain and bony labyrinth may result in hearing loss, vestibular dysfunction, facial paralysis, labyrinthine fistulae and intracranial complications. The exact underlying cellular and molecular mechanism of bone resorption in acquired cholesteatoma still remains unexplained. Pubmed database and China National Knowledge Infrastructure were screened for articles focusing on bone resorption in acquired cholesteatoma. Osteoclast activation, pressure necrosis, acid lysis, enzyme mediation, inflammatory mediators and several newly discovered biomolecules are outlined as main theories behind bone resorption in acquired cholesteatoma, aiming to facilitate the development of potential therapeutic targets for preventing intracranial and extracranial complications caused by bone resorption in acquired middle ear cholesteatoma.

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Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease

Cited by 2 publications

References 24 publications

Evaluation of periostin, fibronectin and tenascin-C in patients chronic otitis media with cholesteatoma

Evaluation of periostin, fibronectin and tenascin-C in patients chronic otitis media with cholesteatoma

The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma

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